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New Opportunities and Challenges of Smart Polymers in Post-Translational Modification Proteomics
Qing, Guangyan1; Lu, Qi1; Xiong, Yuting1; Zhang, Lei1,4; Wang, Hongxi; Li, Xiuling3; Liang, Xinmiao3; Sun, Taolei1,2
KeywordEnrichment Interfaces Post-translational Modification Proteomics Smart Polymers
Source PublicationADVANCED MATERIALS
2017-05-24
DOI10.1002/adma.201604670
Volume29
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS KeywordFUNCTIONALIZED SOLUBLE NANOPOLYMERS ; HIGHLY SPECIFIC ENRICHMENT ; INTERACTION LIQUID-CHROMATOGRAPHY ; N-LINKED GLYCOPEPTIDES ; PHOSPHOPEPTIDE ENRICHMENT ; SELECTIVE ENRICHMENT ; MASS-SPECTROMETRY ; AFFINITY-CHROMATOGRAPHY ; MAGNETIC NANOPARTICLES ; PHOSPHOPROTEOME ANALYSIS
AbstractProtein post-translational modifications (PTMs), which denote covalent additions of various functional groups (e.g., phosphate, glycan, methyl, or ubiquitin) to proteins, significantly increase protein complexity and diversity. PTMs play crucial roles in the regulation of protein functions and numerous cellular processes. However, in a living organism, native PTM proteins are typically present at substoichiometric levels, considerably impeding mass-spectrometry-based analyses and identification. Over the past decade, the demand for in-depth PTM proteomics studies has spawned a variety of selective affinity materials capable of capturing trace amounts of PTM peptides from highly complex biosamples. However, novel design ideas or strategies are urgently required for fulfilling the increasingly complex and accurate requirements of PTM proteomics analysis, which can hardly be met by using conventional enrichment materials. Considering two typical types of protein PTMs, phosphorylation and glycosylation, an overview of polymeric enrichment materials is provided here, with an emphasis on the superiority of smart-polymer-based materials that can function in intelligent modes. Moreover, some smart separation materials are introduced to demonstrate the enticing prospects and the challenges of smart polymers applied in PTM proteomics.
Language英语
WOS IDWOS:000401563200014
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/152293
Collection中国科学院大连化学物理研究所
Affiliation1.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, 122 Luoshi Rd, Wuhan 430070, Peoples R China
2.Wuhan Univ Technol, Int Sch Mat Sci & Engn, 122 Luoshi Rd, Wuhan 430070, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China
4.Hubei Univ Technol, Coll Bioengn, Inst Biomed & Pharmaceut Sci, 28 Nanli Rd, Wuhan 430068, Peoples R China
Recommended Citation
GB/T 7714
Qing, Guangyan,Lu, Qi,Xiong, Yuting,et al. New Opportunities and Challenges of Smart Polymers in Post-Translational Modification Proteomics[J]. ADVANCED MATERIALS,2017,29.
APA Qing, Guangyan.,Lu, Qi.,Xiong, Yuting.,Zhang, Lei.,Wang, Hongxi.,...&Sun, Taolei.(2017).New Opportunities and Challenges of Smart Polymers in Post-Translational Modification Proteomics.ADVANCED MATERIALS,29.
MLA Qing, Guangyan,et al."New Opportunities and Challenges of Smart Polymers in Post-Translational Modification Proteomics".ADVANCED MATERIALS 29(2017).
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