中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: New Opportunities and Challenges of Smart Polymers in Post-Translational Modification Proteomics
作者: Qing, Guangyan1;  Lu, Qi1;  Xiong, Yuting1;  Zhang, Lei1, 4;  Wang, Hongxi;  Li, Xiuling3;  Liang, Xinmiao3;  Sun, Taolei1, 2
关键词: enrichment ;  interfaces ;  post-translational modification ;  proteomics ;  smart polymers
刊名: ADVANCED MATERIALS
发表日期: 2017-05-24
DOI: 10.1002/adma.201604670
卷: 29
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Multidisciplinary ;  Chemistry, Physical ;  Nanoscience & Nanotechnology ;  Materials Science, Multidisciplinary ;  Physics, Applied ;  Physics, Condensed Matter
研究领域[WOS]: Chemistry ;  Science & Technology - Other Topics ;  Materials Science ;  Physics
英文摘要: Protein post-translational modifications (PTMs), which denote covalent additions of various functional groups (e.g., phosphate, glycan, methyl, or ubiquitin) to proteins, significantly increase protein complexity and diversity. PTMs play crucial roles in the regulation of protein functions and numerous cellular processes. However, in a living organism, native PTM proteins are typically present at substoichiometric levels, considerably impeding mass-spectrometry-based analyses and identification. Over the past decade, the demand for in-depth PTM proteomics studies has spawned a variety of selective affinity materials capable of capturing trace amounts of PTM peptides from highly complex biosamples. However, novel design ideas or strategies are urgently required for fulfilling the increasingly complex and accurate requirements of PTM proteomics analysis, which can hardly be met by using conventional enrichment materials. Considering two typical types of protein PTMs, phosphorylation and glycosylation, an overview of polymeric enrichment materials is provided here, with an emphasis on the superiority of smart-polymer-based materials that can function in intelligent modes. Moreover, some smart separation materials are introduced to demonstrate the enticing prospects and the challenges of smart polymers applied in PTM proteomics.
关键词[WOS]: FUNCTIONALIZED SOLUBLE NANOPOLYMERS ;  HIGHLY SPECIFIC ENRICHMENT ;  INTERACTION LIQUID-CHROMATOGRAPHY ;  N-LINKED GLYCOPEPTIDES ;  PHOSPHOPEPTIDE ENRICHMENT ;  SELECTIVE ENRICHMENT ;  MASS-SPECTROMETRY ;  AFFINITY-CHROMATOGRAPHY ;  MAGNETIC NANOPARTICLES ;  PHOSPHOPROTEOME ANALYSIS
语种: 英语
WOS记录号: WOS:000401563200014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/152293
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, 122 Luoshi Rd, Wuhan 430070, Peoples R China
2.Wuhan Univ Technol, Int Sch Mat Sci & Engn, 122 Luoshi Rd, Wuhan 430070, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China
4.Hubei Univ Technol, Coll Bioengn, Inst Biomed & Pharmaceut Sci, 28 Nanli Rd, Wuhan 430068, Peoples R China

Recommended Citation:
Qing, Guangyan,Lu, Qi,Xiong, Yuting,et al. New Opportunities and Challenges of Smart Polymers in Post-Translational Modification Proteomics[J]. ADVANCED MATERIALS,2017,29.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Qing, Guangyan]'s Articles
 [Lu, Qi]'s Articles
 [Xiong, Yuting]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Qing, Guangyan]‘s Articles
 [Lu, Qi]‘s Articles
 [Xiong, Yuting]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace