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题名: Preparation and characterization of hydrophilic hybrid monoliths via thiol-ene click polymerization and their applications in chromatographic analysis and glycopeptides enrichment
作者: Bai, Jingyao1, 2;  Liu, Zhongshan1;  Wang, Hongwei1;  You, Xin1;  Ou, Junjie1;  Shen, Yehua2;  Ye, Mingliang1
关键词: Thiol-ene ;  Hybrid monolith ;  Hydrophilic ;  Capillary liquid chromatography ;  Glycopeptides enrichment
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2017-05-19
DOI: 10.1016/j.chroma.2016.12.031
卷: 1498, 页:37-45
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: A macroporous hydrophilic organic-silica hybrid monolithic column was synthesized via photoinitiated thiol-ene click polymerization reaction of 1-thioglycerol-modified polyhedral oligomeric vinylsilsesquioxane (vinyIPOSS) and dithiothreitol (OTT) in a binary porogenic system consisting of tetrahydrofuran (THF) and dodecanol. 1-Thioglycerol was used to modify vinyIPOSS in order to form a precursor with good solubility in the binary porogenic system. The influences of both the ratio of 1-thioglycerol/vinylPOSS and the porogenic solvents on the morphology and permeability of hybrid monoliths were studied in detail. The physical properties of hybrid monolith were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy and nitrogen adsorption/desorption measurement. The chromatographic performance was evaluated by separation of neutral polar compounds in capillary liquid chromatography (cLC). The resulting column possessed homogeneous macroporous structure and showed hydrophilic interaction liquid chromatography (HILIC) separation mechanism with high efficiency of 65,000 N m(-1) for formamide. Ultimately, the hybrid matrix was grafted with hydrazine groups and then exhibited the ability of glycopeptides enrichment. (C) 2016 Elsevier B.V. All rights reserved.
关键词[WOS]: INTERACTION LIQUID-CHROMATOGRAPHY ;  CAPILLARY COLUMNS ;  SELECTIVE ENRICHMENT ;  SEPARATION SCIENCE ;  MASS-SPECTROMETRY ;  PERFORMANCE ;  EFFICIENT ;  CHEMISTRY ;  HPLC ;  CEC
语种: 英语
WOS记录号: WOS:000401043000006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/152295
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Northwest Univ, Coll Chem & Mat Sci,Key Lab Yulin Desert Plants R, Shaanxi Alcohol Ether & Biomass Energy Engn Res C, Key Lab Synthet & Nat Funct Mol Chem,Minist Educ, Xian 710069, Peoples R China

Recommended Citation:
Bai, Jingyao,Liu, Zhongshan,Wang, Hongwei,et al. Preparation and characterization of hydrophilic hybrid monoliths via thiol-ene click polymerization and their applications in chromatographic analysis and glycopeptides enrichment[J]. JOURNAL OF CHROMATOGRAPHY A,2017,1498:37-45.
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