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Preparation and characterization of hydrophilic hybrid monoliths via thiol-ene click polymerization and their applications in chromatographic analysis and glycopeptides enrichment
Bai, Jingyao1,2; Liu, Zhongshan1; Wang, Hongwei1; You, Xin1; Ou, Junjie1; Shen, Yehua2; Ye, Mingliang1
关键词Thiol-ene Hybrid Monolith Hydrophilic Capillary Liquid Chromatography Glycopeptides Enrichment
刊名JOURNAL OF CHROMATOGRAPHY A
2017-05-19
DOI10.1016/j.chroma.2016.12.031
1498页:37-45
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]INTERACTION LIQUID-CHROMATOGRAPHY ; CAPILLARY COLUMNS ; SELECTIVE ENRICHMENT ; SEPARATION SCIENCE ; MASS-SPECTROMETRY ; PERFORMANCE ; EFFICIENT ; CHEMISTRY ; HPLC ; CEC
英文摘要A macroporous hydrophilic organic-silica hybrid monolithic column was synthesized via photoinitiated thiol-ene click polymerization reaction of 1-thioglycerol-modified polyhedral oligomeric vinylsilsesquioxane (vinyIPOSS) and dithiothreitol (OTT) in a binary porogenic system consisting of tetrahydrofuran (THF) and dodecanol. 1-Thioglycerol was used to modify vinyIPOSS in order to form a precursor with good solubility in the binary porogenic system. The influences of both the ratio of 1-thioglycerol/vinylPOSS and the porogenic solvents on the morphology and permeability of hybrid monoliths were studied in detail. The physical properties of hybrid monolith were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy and nitrogen adsorption/desorption measurement. The chromatographic performance was evaluated by separation of neutral polar compounds in capillary liquid chromatography (cLC). The resulting column possessed homogeneous macroporous structure and showed hydrophilic interaction liquid chromatography (HILIC) separation mechanism with high efficiency of 65,000 N m(-1) for formamide. Ultimately, the hybrid matrix was grafted with hydrazine groups and then exhibited the ability of glycopeptides enrichment. (C) 2016 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000401043000006
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/152295
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Northwest Univ, Coll Chem & Mat Sci,Key Lab Yulin Desert Plants R, Shaanxi Alcohol Ether & Biomass Energy Engn Res C, Key Lab Synthet & Nat Funct Mol Chem,Minist Educ, Xian 710069, Peoples R China
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Bai, Jingyao,Liu, Zhongshan,Wang, Hongwei,et al. Preparation and characterization of hydrophilic hybrid monoliths via thiol-ene click polymerization and their applications in chromatographic analysis and glycopeptides enrichment[J]. JOURNAL OF CHROMATOGRAPHY A,2017,1498:37-45.
APA Bai, Jingyao.,Liu, Zhongshan.,Wang, Hongwei.,You, Xin.,Ou, Junjie.,...&Ye, Mingliang.(2017).Preparation and characterization of hydrophilic hybrid monoliths via thiol-ene click polymerization and their applications in chromatographic analysis and glycopeptides enrichment.JOURNAL OF CHROMATOGRAPHY A,1498,37-45.
MLA Bai, Jingyao,et al."Preparation and characterization of hydrophilic hybrid monoliths via thiol-ene click polymerization and their applications in chromatographic analysis and glycopeptides enrichment".JOURNAL OF CHROMATOGRAPHY A 1498(2017):37-45.
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