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题名: Epitope molecularly imprinted polymer coated quartz crystal microbalance sensor for the determination of human serum albumin
作者: Ma, Xiao-Tong1;  He, Xi-Wen1;  Li, Wen-You1, 2;  Zhang, Yu-Kui1, 3
关键词: Epitope imprinting ;  Quartz crystal microbalance ;  Protein detection ;  Human serum albumin
刊名: SENSORS AND ACTUATORS B-CHEMICAL
发表日期: 2017-07-01
DOI: 10.1016/j.snb.2017.02.137
卷: 246, 页:879-886
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Analytical ;  Electrochemistry ;  Instruments & Instrumentation
研究领域[WOS]: Chemistry ;  Electrochemistry ;  Instruments & Instrumentation
英文摘要: Quantitative determination of biomacromolecules has great significance. Quartz crystal microbalance sensors are favored by their sensibility while their selectivity was limited. Molecularly imprinted polymer has great selectivity performance. By combining the advantages of quartz crystal microbalance and molecularly imprinted polymer, this work established an epitope molecularly imprinted polymer based quartz crystal microbalance sensor. Using the epitope of human serum albumin as the template, the epitope molecularly imprinted polymer (EMIP) was successfully synthesized. Then a simple coating method was applied to fabricate the epitope molecularly imprinted polymer based quartz crystal microbalance sensor (EMIP-QCM). The EMIP-QCM sensor had good sensibility and selectivity to the target human serum albumin. The linear range was from 0.050u.,mu gmL(-1) to 0.500 mu gmL(-1) and the detection limit was calculated to be 0.026 mu g mL(-1). In addition, it could be used in real sample analysis and had good accuracy and reproducibility. This method proposed a general and simple way of establishing quartz crystal microbalance sensors for sensitive determination of biomacromolecules. (C) 2017 Elsevier B.V. All rights reserved.
关键词[WOS]: SELECTIVE DETERMINATION ;  PROTEIN RECOGNITION ;  IMMUNOGLOBULIN-G ;  QCM SENSOR ;  SURFACE ;  FILMS ;  NANOPARTICLES ;  ACID ;  MACROMOLECULES ;  DISCRIMINATION
语种: 英语
WOS记录号: WOS:000400803700107
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/152296
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nankai Univ, Tianjin Key Lab Biosensing & Mol Recognit, State Key Lab Med Chem Biol, Coll Chem,Res Ctr Analyt Sci, Tianjin 300071, Peoples R China
2.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China

Recommended Citation:
Ma, Xiao-Tong,He, Xi-Wen,Li, Wen-You,et al. Epitope molecularly imprinted polymer coated quartz crystal microbalance sensor for the determination of human serum albumin[J]. SENSORS AND ACTUATORS B-CHEMICAL,2017,246:879-886.
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