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Epitope molecularly imprinted polymer coated quartz crystal microbalance sensor for the determination of human serum albumin
Ma, Xiao-Tong1; He, Xi-Wen1; Li, Wen-You1,2; Zhang, Yu-Kui1,3
KeywordEpitope Imprinting Quartz Crystal Microbalance Protein Detection Human Serum Albumin
Source PublicationSENSORS AND ACTUATORS B-CHEMICAL
2017-07-01
DOI10.1016/j.snb.2017.02.137
Volume246Pages:879-886
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
WOS SubjectChemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
WOS Research AreaChemistry ; Electrochemistry ; Instruments & Instrumentation
WOS KeywordSELECTIVE DETERMINATION ; PROTEIN RECOGNITION ; IMMUNOGLOBULIN-G ; QCM SENSOR ; SURFACE ; FILMS ; NANOPARTICLES ; ACID ; MACROMOLECULES ; DISCRIMINATION
AbstractQuantitative determination of biomacromolecules has great significance. Quartz crystal microbalance sensors are favored by their sensibility while their selectivity was limited. Molecularly imprinted polymer has great selectivity performance. By combining the advantages of quartz crystal microbalance and molecularly imprinted polymer, this work established an epitope molecularly imprinted polymer based quartz crystal microbalance sensor. Using the epitope of human serum albumin as the template, the epitope molecularly imprinted polymer (EMIP) was successfully synthesized. Then a simple coating method was applied to fabricate the epitope molecularly imprinted polymer based quartz crystal microbalance sensor (EMIP-QCM). The EMIP-QCM sensor had good sensibility and selectivity to the target human serum albumin. The linear range was from 0.050u.,mu gmL(-1) to 0.500 mu gmL(-1) and the detection limit was calculated to be 0.026 mu g mL(-1). In addition, it could be used in real sample analysis and had good accuracy and reproducibility. This method proposed a general and simple way of establishing quartz crystal microbalance sensors for sensitive determination of biomacromolecules. (C) 2017 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000400803700107
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/152296
Collection中国科学院大连化学物理研究所
Affiliation1.Nankai Univ, Tianjin Key Lab Biosensing & Mol Recognit, State Key Lab Med Chem Biol, Coll Chem,Res Ctr Analyt Sci, Tianjin 300071, Peoples R China
2.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Ma, Xiao-Tong,He, Xi-Wen,Li, Wen-You,et al. Epitope molecularly imprinted polymer coated quartz crystal microbalance sensor for the determination of human serum albumin[J]. SENSORS AND ACTUATORS B-CHEMICAL,2017,246:879-886.
APA Ma, Xiao-Tong,He, Xi-Wen,Li, Wen-You,&Zhang, Yu-Kui.(2017).Epitope molecularly imprinted polymer coated quartz crystal microbalance sensor for the determination of human serum albumin.SENSORS AND ACTUATORS B-CHEMICAL,246,879-886.
MLA Ma, Xiao-Tong,et al."Epitope molecularly imprinted polymer coated quartz crystal microbalance sensor for the determination of human serum albumin".SENSORS AND ACTUATORS B-CHEMICAL 246(2017):879-886.
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