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The inhibition of UDP-glucuronosyltransferases (UGTs) by vitamin A
Liu, Xin1; Cao, Yun-Feng2,3,4; Dong, Pei-Pei5; Zhu, Liang-Liang6; Zhao, Zhenying7; Wu, Xue2,3,4; Fu, Zhi-Wei2,3,4; Huang, Chun-Ting2,3,4; Fang, Zhong-Ze7,8; Sun, Hong-Zhi1
关键词Enzyme Inhibition Udp-glucuronosyltransferases (Ugts) Vitamin a
刊名XENOBIOTICA
2017
DOI10.1080/00498254.2016.1198841
47页:376-381
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]DRUG-METABOLISM ; RETINOIC ACID ; SUBSTRATE ; EXPRESSION ; UGT2B7 ; 2B7 ; HYPERBILIRUBINEMIA ; PHARMACOKINETICS ; SELECTIVITY ; ISOFORMS
英文摘要The exposed level of vitamin A in plasma might be exceeded due to the both inadvertent and clinical utilization. The adverse effects of vitamin A have been frequently reported, however, the mechanism remains unclear. The inhibition of vitamin A on the activity of UDP-glucuronosyltransferases (UGTs) was determined using in vitro incubation system to explain the adverse effects of vitamin A from a new perspective.
语种英语
WOS记录号WOS:000399497600003
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/152330
专题中国科学院大连化学物理研究所
作者单位1.Liaoning Med Univ, Affiliated Hosp 1, Jinzhou, Liaoning, Peoples R China
2.RSKT Biopharma Inc, Dalian, Liaoning, Peoples R China
3.Chinese Acad Sci, Joint Ctr Translat Med, Dalian Inst Chem Phys, Dalian, Peoples R China
4.Liaoning Med Univ, Affiliated Hosp 1, Dalian, Peoples R China
5.Dalian Med Univ, Inst Integrat Med, Dalian, Peoples R China
6.Anqing Normal Univ, Sch Life Sci, Dept Food Sci & Technol, Anqing, Peoples R China
7.Tianjin Union Med Ctr, Tianjin, Peoples R China
8.Tianjin Med Univ, Sch Publ Hlth, Dept Toxicol, Tianjin, Peoples R China
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GB/T 7714
Liu, Xin,Cao, Yun-Feng,Dong, Pei-Pei,et al. The inhibition of UDP-glucuronosyltransferases (UGTs) by vitamin A[J]. XENOBIOTICA,2017,47:376-381.
APA Liu, Xin.,Cao, Yun-Feng.,Dong, Pei-Pei.,Zhu, Liang-Liang.,Zhao, Zhenying.,...&Sun, Hong-Zhi.(2017).The inhibition of UDP-glucuronosyltransferases (UGTs) by vitamin A.XENOBIOTICA,47,376-381.
MLA Liu, Xin,et al."The inhibition of UDP-glucuronosyltransferases (UGTs) by vitamin A".XENOBIOTICA 47(2017):376-381.
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