DICP OpenIR
Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry
Mu, Ying1,4; Zhou, Yang2,3; Wang, Yanfeng2,5; Li, Wei1; Zhou, Lina2; Lu, Xin2; Gao, Peng6; Gao, Mingyang1; Zhao, Yanhui4; Wang, Qi3; Wang, Yanfu1; Xu, Guowang2
Corresponding AuthorWang, Yanfu(wangyanfu2000@163.com) ; Xu, Guowang(xugw@dicp.ac.cn)
Keywordnon-small cell lung cancer metabolomics nonsmoking female gas chromatography-mass spectrometry biomarker
Source PublicationJOURNAL OF PROTEOME RESEARCH
2019-05-01
ISSN1535-3893
DOI10.1021/acs.jproteome.9b00069
Volume18Issue:5Pages:2175-2184
Funding ProjectLiaoning Provincial Natural Science Foundation of China[2012225020] ; Liaoning Provincial Natural Science Foundation of China[20180530107]
Funding OrganizationLiaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China
WOS SubjectBiochemical Research Methods
WOS Research AreaBiochemistry & Molecular Biology
WOS KeywordNEVER-SMOKERS ; POTENTIAL BIOMARKERS ; METABOLITE PROFILES ; PROSTATE-CANCER ; METABONOMICS ; GLUTATHIONE ; SIGNATURES ; DISCOVERY ; SURVIVAL ; ADENOCARCINOMA
AbstractThe incidence of nonsmoking female patients with non-small cell lung cancer (NSCLC) has increased in recent decades; however, the pathogenesis of patients is unclear, and early diagnosis biomarkers are in urgent need. In this study, 136 nonsmoking female subjects (65 patients with NSCLC, 6 patients with benign lung tumors, and 65 healthy controls) were enrolled, and their metabolic profiling was investigated by using pseudotargeted gas chromatography mass spectrometry. A total of 56 annotated metabolites were found and verified to be significantly different in nonsmoking females with NSCLC compared with the control. The metabolic profiling was featured by disturbed energy metabolism, amino acid metabolism, oxidative stress, lipid metabolism, and so on. Cysteine, serine, and 1-monooleoylglycerol were defined as the biomarker panel for the diagnosis of NSCLC patients. 98.5 and 91.4% of subjects were correctly distinguished in the discovery and validation sets, respectively. The biomarker panel was also useful for the diagnosis of in situ malignancy patients, with an accuracy of 97.7 and 97.8% in the discovery and validation sets, respectively. The study provides a biomarker panel for the auxiliary diagnosis of nonsmoking females with NSCLC.
Language英语
Funding OrganizationLiaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China
WOS IDWOS:000467317700022
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/165469
Collection中国科学院大连化学物理研究所
Corresponding AuthorWang, Yanfu; Xu, Guowang
Affiliation1.Dalian Med Univ, Affiliated Hosp 1, Dalian 116000, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Dalian Med Univ, Affiliated Hosp 2, Dalian 116027, Peoples R China
4.Lib Liaoning Univ Tradit Chinese Med, Dalian Branch, Dalian 116600, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Dalian Sixth Peoples Hosp, Clin Lab, Dalian 116031, Peoples R China
Recommended Citation
GB/T 7714
Mu, Ying,Zhou, Yang,Wang, Yanfeng,et al. Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry[J]. JOURNAL OF PROTEOME RESEARCH,2019,18(5):2175-2184.
APA Mu, Ying.,Zhou, Yang.,Wang, Yanfeng.,Li, Wei.,Zhou, Lina.,...&Xu, Guowang.(2019).Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry.JOURNAL OF PROTEOME RESEARCH,18(5),2175-2184.
MLA Mu, Ying,et al."Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry".JOURNAL OF PROTEOME RESEARCH 18.5(2019):2175-2184.
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