DICP OpenIR
Preparation of a Ruthenium-Complex-Functionalized Two-Photon-Excited Red Fluorescence Silicon Nanoparticle Composite for Targeted Fluorescence Imaging and Photodynamic Therapy in Vitro
Dou, Ya-Kun1; Shang, Yue2; He, Xi-Wen1; Li, Wen-You1,3; Li, Yu-Hao2; Zhang, Yu-Kui1,4
Corresponding AuthorLi, Wen-You(wyli@nankai.edu.cn) ; Li, Yu-Hao(liyuhao@nankai.edu.cn)
Keywordsilicon nanoparticle composite two-photon excitation fluorescence resonance energy transfer targeted fluorescence imaging photodynamic therapy in vitro
Source PublicationACS APPLIED MATERIALS & INTERFACES
2019-04-17
ISSN1944-8244
DOI10.1021/acsami.9b00288
Volume11Issue:15Pages:13954-13963
Funding ProjectNational Natural Science Foundation of China[21775077] ; National Natural Science Foundation of China[21475069] ; National Natural Science Foundation of China[81671179] ; Tianjin Natural Science Foundation[16JCZDJC37200]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS KeywordGRAPHENE QUANTUM DOTS ; CARBON DOTS ; ROOM-TEMPERATURE ; CONTRAST AGENTS ; PHOTOSENSITIZERS ; LUMINESCENCE ; CYTOTOXICITY ; SIZE
AbstractSilicon nanoparticles (SiNPs), especially those emitting red fluorescence, have been widely applied in the field of bioimaging. However, harsh synthetic conditions and strong biological autofluorescence caused by short wavelength excitation restrict the further development of SiNPs in the field of biological applications. Here, we report a method for synthesizing a ruthenium-complex-functionalized two-photon excited red fluorescence silicon nanoparticle composite (SiNPs Ru) based on fluorescence resonance energy transfer under mild experimental conditions. In the prepared SiNPs Ru composite, silicon nanoparticles synthesized by atmospheric pressure microwave-assisted synthesis served as a fluorescence energy donor, which had two-photon fluorescence properties, and tris(4,4'-dicarboxylic acid-2,2-bipyridyl)ruthenium(II) dichloride (LRu) acted as a fluorescence energy acceptor, which could emit red fluorescence as well as had the ability to produce singlet-oxygen for photodynamic therapy. Therefore, the synthesized SiNPs Ru could emit red fluorescence by two-photon excitation based on fluorescence resonance energy transfer, which could effectively avoid the interference of biological autofluorescence. Fluorescence imaging tests in zebrafish and nude mice indicated that the as-prepared SiNPs Ru could act as a new kind of fluorescence probe for fluorescence imaging in vivo. By coupling folic acid (FA) to SiNPs Ru, the prepared composite (FA SiNPs Ru) could not only serve as a targeted two photon fluorescence imaging probe but also kill cancer cells via photodynamic therapy in vitro.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation
WOS IDWOS:000465189000014
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/165505
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi, Wen-You; Li, Yu-Hao
Affiliation1.Nankai Univ, Tianjin Key Lab Biosensing & Mol Recognit, State Key Lab Med Chem Biol, Coll Chem,Res Ctr Analyt Sci, Tianjin 300071, Peoples R China
2.Nankai Univ, Key Lab Tumor Microenvironm & Neurovasc Regulat, Sch Med, Tianjin 300071, Peoples R China
3.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Dou, Ya-Kun,Shang, Yue,He, Xi-Wen,et al. Preparation of a Ruthenium-Complex-Functionalized Two-Photon-Excited Red Fluorescence Silicon Nanoparticle Composite for Targeted Fluorescence Imaging and Photodynamic Therapy in Vitro[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(15):13954-13963.
APA Dou, Ya-Kun,Shang, Yue,He, Xi-Wen,Li, Wen-You,Li, Yu-Hao,&Zhang, Yu-Kui.(2019).Preparation of a Ruthenium-Complex-Functionalized Two-Photon-Excited Red Fluorescence Silicon Nanoparticle Composite for Targeted Fluorescence Imaging and Photodynamic Therapy in Vitro.ACS APPLIED MATERIALS & INTERFACES,11(15),13954-13963.
MLA Dou, Ya-Kun,et al."Preparation of a Ruthenium-Complex-Functionalized Two-Photon-Excited Red Fluorescence Silicon Nanoparticle Composite for Targeted Fluorescence Imaging and Photodynamic Therapy in Vitro".ACS APPLIED MATERIALS & INTERFACES 11.15(2019):13954-13963.
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