DICP OpenIR
One-step fabrication of cinchona-based hybrid monolithic chiral stationary phases via photo-initiated thiol-ene polymerization for cLC enantioseparation
Ma, Shujuan1,2; Wang, Yan1,2; Zhang, Haiyang1,2; Li, Ya1,2; Ou, Junjie1; Wei, Yinmao2; Ye, Mingliang1
Corresponding AuthorOu, Junjie(junjieou@dicp.ac.cn) ; Wei, Yinmao(ymwei@nwu.edu.cn)
KeywordChiral stationary phase Hybrid monolith Thiol-ene click reaction Capillary liquid chromatography Polyhedral oligomeric silsesquioxanes
Source PublicationTALANTA
2019-06-01
ISSN0039-9140
DOI10.1016/j.talanta.2019.02.046
Volume198Pages:432-439
Funding ProjectChina State Key Basic Research Program Grant[2016YFA0501402] ; National Science Fund for Distinguished Young Scholars[21525524] ; National Natural Science Foundation of China[21575141] ; CAS-Weigao Research & Development Program[[2017]-009]
Funding OrganizationChina State Key Basic Research Program Grant ; China State Key Basic Research Program Grant ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program ; China State Key Basic Research Program Grant ; China State Key Basic Research Program Grant ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program ; China State Key Basic Research Program Grant ; China State Key Basic Research Program Grant ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program ; China State Key Basic Research Program Grant ; China State Key Basic Research Program Grant ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordRING-OPENING POLYMERIZATION ; LIQUID-CHROMATOGRAPHY ; CLICK POLYMERIZATION ; CAPILLARY COLUMNS ; ACRYLATE POLYMERIZATION ; RADICAL POLYMERIZATION ; CROSS-LINKER ; AMINO-ACIDS ; PERFORMANCE ; SEPARATION
AbstractAlthough various click polymerization reactions (thiol-ene, thiol-yne, thiol-Michael, thiol-epoxy and amine epoxy) have been utilized to prepare either hybrid or organic monolithic columns with homogeneous network structures, there were few reports on fabrication of monolithic CSPs via click polymerization. Herein, a fast and robust approach was explored to fabricate cinchona-based monolithic hybrid CSPs via photo-initiated thiol-ene polymerization within 10 min in one step. A self-synthesized octakis(3-mercaptopropyl) octasilsesquioxane (POSS-SH) was polymerized with phenylisocyanate cinchonidine (PCD) and (+)-N,N'-diallyl-L-tartardiamide (DATDA) or 1,2,4-trivinylcyclohexane (TVCH). The resulting two kinds of as-synthesized monolithic CSPs, poly (POSS-co-DATDA-co-PCD) and poly(POSS-co-TVCH-co-PCD), were evaluated for cLC enantioseparation of acidic racemates. It was found that they exhibited different enantioseparation ability due to using different multivinyl crosslinkers. The influence of ACN content in mobile phase on the enantioseparation of acidic racemates was investigated. The separation mechanism was also discussed on the basis of a comparison of enantioseparation on two kinds of hybrid monolithic CSPs.
Language英语
Funding OrganizationChina State Key Basic Research Program Grant ; China State Key Basic Research Program Grant ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program ; China State Key Basic Research Program Grant ; China State Key Basic Research Program Grant ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program ; China State Key Basic Research Program Grant ; China State Key Basic Research Program Grant ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program ; China State Key Basic Research Program Grant ; China State Key Basic Research Program Grant ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program
WOS IDWOS:000462803400057
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/165567
Collection中国科学院大连化学物理研究所
Corresponding AuthorOu, Junjie; Wei, Yinmao
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Northwest Univ, Coll Chem & Mat Sci, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Shaanxi, Peoples R China
Recommended Citation
GB/T 7714
Ma, Shujuan,Wang, Yan,Zhang, Haiyang,et al. One-step fabrication of cinchona-based hybrid monolithic chiral stationary phases via photo-initiated thiol-ene polymerization for cLC enantioseparation[J]. TALANTA,2019,198:432-439.
APA Ma, Shujuan.,Wang, Yan.,Zhang, Haiyang.,Li, Ya.,Ou, Junjie.,...&Ye, Mingliang.(2019).One-step fabrication of cinchona-based hybrid monolithic chiral stationary phases via photo-initiated thiol-ene polymerization for cLC enantioseparation.TALANTA,198,432-439.
MLA Ma, Shujuan,et al."One-step fabrication of cinchona-based hybrid monolithic chiral stationary phases via photo-initiated thiol-ene polymerization for cLC enantioseparation".TALANTA 198(2019):432-439.
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