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Enantioselective Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones through Organocatalytic Transfer Hydrogenation of 2-Hydroxypyrimidines
Meng, Fan-Jie1,2; Shi, Lei1,2; Feng, Guang-Shou1; Sun, Lei1; Zhou, Yong-Gui1
Corresponding AuthorShi, Lei(shileichem@dlut.edu.cn) ; Zhou, Yong-Gui(ygzhou@dicp.ac.cn)
Source PublicationJOURNAL OF ORGANIC CHEMISTRY
2019-04-05
ISSN0022-3263
DOI10.1021/acs.joc.8b03128
Volume84Issue:7Pages:4435-4442
Funding ProjectNational Natural Science Foundation of China[21772195] ; National Natural Science Foundation of China[21532006] ; Strategic Priority Program of Chinese Academy of Sciences[XDB17020300]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of Chinese Academy of Sciences ; Strategic Priority Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of Chinese Academy of Sciences ; Strategic Priority Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of Chinese Academy of Sciences ; Strategic Priority Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of Chinese Academy of Sciences ; Strategic Priority Program of Chinese Academy of Sciences
WOS SubjectChemistry, Organic
WOS Research AreaChemistry
WOS KeywordASYMMETRIC HYDROGENATION ; BIGINELLI REACTIONS ; BRONSTED ACID ; EFFICIENT ; AGENT ; AMINE ; DEHYDROGENATION ; ACTIVATION ; RESOLUTION ; CATALYST
AbstractChiral phosphoric acid-catalyzed transfer hydrogenation of 2-hydroxypyrimidines has been successfully realized using Hantzsch ester or dihydrophenanthridine as the hydrogen source, furnishing the chiral 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) with excellent yields and enantioselectivities of <= 99%. Notably, a novel kind of chiral DHPMs with an alkyl stereogenic center can be prepared through highly chemoselective transfer hydrogenation.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of Chinese Academy of Sciences ; Strategic Priority Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of Chinese Academy of Sciences ; Strategic Priority Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of Chinese Academy of Sciences ; Strategic Priority Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of Chinese Academy of Sciences ; Strategic Priority Program of Chinese Academy of Sciences
WOS IDWOS:000464250800067
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/165675
Collection中国科学院大连化学物理研究所
Corresponding AuthorShi, Lei; Zhou, Yong-Gui
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Dalian Univ Technol, Sch Chem, State Key Lab Fine Chem, Dalian 116024, Peoples R China
Recommended Citation
GB/T 7714
Meng, Fan-Jie,Shi, Lei,Feng, Guang-Shou,et al. Enantioselective Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones through Organocatalytic Transfer Hydrogenation of 2-Hydroxypyrimidines[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(7):4435-4442.
APA Meng, Fan-Jie,Shi, Lei,Feng, Guang-Shou,Sun, Lei,&Zhou, Yong-Gui.(2019).Enantioselective Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones through Organocatalytic Transfer Hydrogenation of 2-Hydroxypyrimidines.JOURNAL OF ORGANIC CHEMISTRY,84(7),4435-4442.
MLA Meng, Fan-Jie,et al."Enantioselective Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones through Organocatalytic Transfer Hydrogenation of 2-Hydroxypyrimidines".JOURNAL OF ORGANIC CHEMISTRY 84.7(2019):4435-4442.
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