DICP OpenIR
Long Noncoding RNA (IncRNA) Small Nucleolar RNA Host Gene 16 (SNHG16) Predicts Poor Prognosis and Sorafenib Resistance in Hepatocellular Carcinoma
Guo, Zhenli1,2; Zhang, Ju1,3; Fan, Lulu1; Liu, Jiatao1; Yu, Hanging1; Li, Xiaoqiu1; Sun, Guoping1
Corresponding AuthorSun, Guoping(sungp@ahmu.edu.cn)
KeywordCarcinoma, Hepatocellular Prognosis RNA, Long Noncoding
Source PublicationMEDICAL SCIENCE MONITOR
2019-03-20
ISSN1643-3750
DOI10.12659/MSM.915541
Volume25Pages:2079-2086
Funding ProjectNational Nature and Science Foundation of China[81872047]
Funding OrganizationNational Nature and Science Foundation of China ; National Nature and Science Foundation of China ; National Nature and Science Foundation of China ; National Nature and Science Foundation of China ; National Nature and Science Foundation of China ; National Nature and Science Foundation of China ; National Nature and Science Foundation of China ; National Nature and Science Foundation of China
WOS SubjectMedicine, Research & Experimental
WOS Research AreaResearch & Experimental Medicine
WOS KeywordCANCER ; SURVEILLANCE ; CHROMATIN ; CATENIN
AbstractBackground: Long noncoding RNAs (IncRNAs) play important roles in cancer development and therapeutic resistance. However, the role of small nucleolar RNA host gene 16 (SNHG16) in the development of hepatocellular carcinoma (HCC) remains largely unknown. Material/Methods: In situ hybridization (ISH) staining was performed to detect the expression level of SNHG16 in HCC tissues and adjacent non-cancerous tissues. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the level of SNHG16 in HCC samples, adjacent non-cancerous tissues and HCC cell lines. Transwell assay was performed to investigate the migration and invasion ability of HCC cells. Cell viability assays were performed to determine the ability of proliferation and sorafenib resistance of HCC cells. Results: We found that SNHG16 was upregulated in HCC tissues and cell lines and that it was negatively correlated with survival time in HCC patients. Univariate and multivariate analyses revealed that SNHG16 was a significant and independent predictor for the overall survival of HCC patients. Furthermore, downregulation of SNHG16 inhibited proliferation, migration, invasion, and sorafenib resistance in hepatocellular carcinoma cell lines. Conclusions: Our findings revealed that IncRNA SNHG16 could be used as an oncogene to predict the outcome of hepato-cellular carcinoma.
Language英语
Funding OrganizationNational Nature and Science Foundation of China ; National Nature and Science Foundation of China ; National Nature and Science Foundation of China ; National Nature and Science Foundation of China ; National Nature and Science Foundation of China ; National Nature and Science Foundation of China ; National Nature and Science Foundation of China ; National Nature and Science Foundation of China
WOS IDWOS:000463273900003
PublisherINT SCIENTIFIC INFORMATION, INC
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/165699
Collection中国科学院大连化学物理研究所
Corresponding AuthorSun, Guoping
Affiliation1.Anhui Med Univ, Affiliated Hosp 1, Dept Oncol, Hefei, Anhui, Peoples R China
2.Univ Sci & Technol China, Affiliated Hosp 1, Dept Pathol, Hefei, Anhui, Peoples R China
3.Univ Sci & Technol China, Affiliated Hosp 1, Dept Lab Med, Hefei, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Guo, Zhenli,Zhang, Ju,Fan, Lulu,et al. Long Noncoding RNA (IncRNA) Small Nucleolar RNA Host Gene 16 (SNHG16) Predicts Poor Prognosis and Sorafenib Resistance in Hepatocellular Carcinoma[J]. MEDICAL SCIENCE MONITOR,2019,25:2079-2086.
APA Guo, Zhenli.,Zhang, Ju.,Fan, Lulu.,Liu, Jiatao.,Yu, Hanging.,...&Sun, Guoping.(2019).Long Noncoding RNA (IncRNA) Small Nucleolar RNA Host Gene 16 (SNHG16) Predicts Poor Prognosis and Sorafenib Resistance in Hepatocellular Carcinoma.MEDICAL SCIENCE MONITOR,25,2079-2086.
MLA Guo, Zhenli,et al."Long Noncoding RNA (IncRNA) Small Nucleolar RNA Host Gene 16 (SNHG16) Predicts Poor Prognosis and Sorafenib Resistance in Hepatocellular Carcinoma".MEDICAL SCIENCE MONITOR 25(2019):2079-2086.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Guo, Zhenli]'s Articles
[Zhang, Ju]'s Articles
[Fan, Lulu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Guo, Zhenli]'s Articles
[Zhang, Ju]'s Articles
[Fan, Lulu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Guo, Zhenli]'s Articles
[Zhang, Ju]'s Articles
[Fan, Lulu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.