DICP OpenIR
Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer
Wang, Shuang1,2; Wang, Weimin1,2; Li, Hong3; Xing, Yuming3; Hou, Keyong1; Li, Haiyang1
Corresponding AuthorHou, Keyong(houky@dicp.ac.cn) ; Li, Haiyang(hli@dicp.ac.cn)
Source PublicationANALYTICAL CHEMISTRY
2019-03-19
ISSN0003-2700
DOI10.1021/acs.analchem.8b04168
Volume91Issue:6Pages:3845-3851
Funding ProjectNational Natural Science Foundation of China[21675155] ; National Key Research and Development Program of China[2016YFC0800902] ; DICP[DICP ZZBS201701]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordATMOSPHERIC-PRESSURE PHOTOIONIZATION ; MOBILITY SPECTROMETRY ; AMBIENT IONIZATION ; RAMAN-SPECTROSCOPY ; CROSS-SECTIONS ; CANNABINOIDS ; PERFORMANCE ; PEOPLE ; ABUSE
AbstractIllegal drug smugglings and crimes have long been a global concern, and an apparatus which can identify drugs on-the-spot is urgently demanded by law enforcement. A thermal desorption acetone-assisted photoionization miniature ion trap mass spectrometer was developed for on-site and rapid identification of illegal drugs at checkpoints. Acetone was chosen for dopant-assisted photoionization, and the sensitivity of selected drugs was further enhanced with protonated analyte molecular ions [M + H](+). For example, the sensitivity of ephedrine was improved by as high as 22-fold. The mass discrimination effect, which was usually considered as a shortcoming of ion trap mass analyzer, was ingeniously utilized to eliminate the protonated acetone reagent ions and maximize the trapping efficiency of analyte ions in mass analyzer. Twenty-seven drugs were analyzed, and the limits of detection (LODs) of selected illegal drugs were at the nanogram level with analysis time of 2 s. Analyte/dopant ion peak intensity ratios in mass spectra could be used for quantitation to improve the quantitative analysis performance of miniature ion trap mass spectrometer equipped with a discontinuous atmospheric pressure interface (DAPI) with the prerequisite that dopant ions and analyte ions could be simultaneously and effectively trapped by the ion trap. The RSD of signal intensity was reduced from 25.3% to 8.5%, and the linear range was extended from 0.5-25 to 0.5-100 ng/mu L for methamphetamine. A temperature-resolved thermal desorption sampling strategy was developed and used to distinguish illegal drug components in plant-based drug samples and drinks containing illegal drugs.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP
WOS IDWOS:000462098300014
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/165713
Collection中国科学院大连化学物理研究所
Corresponding AuthorHou, Keyong; Li, Haiyang
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
3.Yunnan Police Officer Acad, 249 Jiaochang North Rd, Kunming 650223, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Wang, Shuang,Wang, Weimin,Li, Hong,et al. Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer[J]. ANALYTICAL CHEMISTRY,2019,91(6):3845-3851.
APA Wang, Shuang,Wang, Weimin,Li, Hong,Xing, Yuming,Hou, Keyong,&Li, Haiyang.(2019).Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer.ANALYTICAL CHEMISTRY,91(6),3845-3851.
MLA Wang, Shuang,et al."Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer".ANALYTICAL CHEMISTRY 91.6(2019):3845-3851.
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