DICP OpenIR
Characterization of tropane and cinnamamide alkaloids from Scopolia tangutica by high-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry
Du, Nana1,2; Zhou, Weijia1,2; Jin, Hongli1; Liu, Yanfang1; Zhou, Han1; Liang, Xinmiao1
Corresponding AuthorLiu, Yanfang(liuyanfang@dicp.ac.cn) ; Liang, Xinmiao(liangxm@dicp.ac.cn)
Keywordcinnamamide quadrupole time-of-flight tandem mass spectrometry Scopolia tangutica tropane alkaloids
Source PublicationJOURNAL OF SEPARATION SCIENCE
2019-03-01
ISSN1615-9306
DOI10.1002/jssc.201801201
Volume42Issue:6Pages:1163-1173
Funding ProjectNational Natural Science Foundation of China[U1508221] ; National Natural Science Foundation of China[21405155] ; National Natural Science Foundation of China[31670374] ; DICP-CMC Innovation Institute of Medicine ; [DICP TMSR201601]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP-CMC Innovation Institute of Medicine ; DICP-CMC Innovation Institute of Medicine ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP-CMC Innovation Institute of Medicine ; DICP-CMC Innovation Institute of Medicine ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP-CMC Innovation Institute of Medicine ; DICP-CMC Innovation Institute of Medicine ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP-CMC Innovation Institute of Medicine ; DICP-CMC Innovation Institute of Medicine
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordQUANTITATIVE-ANALYSIS ; PANCREATIC-SECRETION ; RAT URINE ; METABOLITES ; SCOPOLAMINE ; ATROPINE ; AMIDES ; L. ; PURIFICATION ; ANISODAMINE
AbstractScopolia tangutica is a traditional Chinese medicine used for antispasmodic, anesthesia, analgesia, and sedation. Its medicinal activity is associated to alkaloid constituents, including tropane and cinnamamide types. Low content of alkaloids in plant makes them difficult to be isolated and identified. The present work developed an effective method to quickly characterize alkaloids from Scopolia tangutica by highperformance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. Thirteen reference compounds were studied for their fragmentation pathways, including five tropane alkaloids and eight cinnamamide ones. Alkaloid constituent was analyzed by an optimized high-performance liquid chromatography method and mass spectrometry analysis to achieve systematic characterization of alkaloids fromScopolia tangutica. As a result, 53 compoundswere identified, including 21 tropane alkaloids (eight new ones), 18 caffeoyl ones (ten new ones) and 14 dicaffeoyl ones (seven new ones). It was important to provide rich information in phytochemical study and structure-guided isolation of important compounds from this plant.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP-CMC Innovation Institute of Medicine ; DICP-CMC Innovation Institute of Medicine ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP-CMC Innovation Institute of Medicine ; DICP-CMC Innovation Institute of Medicine ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP-CMC Innovation Institute of Medicine ; DICP-CMC Innovation Institute of Medicine ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP-CMC Innovation Institute of Medicine ; DICP-CMC Innovation Institute of Medicine
WOS IDWOS:000462257700005
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/165759
Collection中国科学院大连化学物理研究所
Corresponding AuthorLiu, Yanfang; Liang, Xinmiao
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Du, Nana,Zhou, Weijia,Jin, Hongli,et al. Characterization of tropane and cinnamamide alkaloids from Scopolia tangutica by high-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry[J]. JOURNAL OF SEPARATION SCIENCE,2019,42(6):1163-1173.
APA Du, Nana,Zhou, Weijia,Jin, Hongli,Liu, Yanfang,Zhou, Han,&Liang, Xinmiao.(2019).Characterization of tropane and cinnamamide alkaloids from Scopolia tangutica by high-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry.JOURNAL OF SEPARATION SCIENCE,42(6),1163-1173.
MLA Du, Nana,et al."Characterization of tropane and cinnamamide alkaloids from Scopolia tangutica by high-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry".JOURNAL OF SEPARATION SCIENCE 42.6(2019):1163-1173.
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