DICP OpenIR
Metabolic phenotypes and the gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects: a randomized crossover trial
Zhang, Lei1,2,3; Ouyang, Yang4,5; Li, Huating1,2; Shen, Li6; Ni, Yueqiong7,8,9; Fang, Qichen1,2; Wu, Guangyu1,2,3; Qian, Lingling1,2,3; Xiao, Yunfeng; Zhang, Jing1,2,3; Yin, Peiyuan4; Panagiotou, Gianni7,8,9; Xu, Guowang4; Ye, Jianping1,2,11; Jia, Weiping1,2
Corresponding AuthorLi, Huating(huarting99@sjtu.edu.cn) ; Xu, Guowang(xugw@dicp.ac.cn) ; Jia, Weiping(wpjia@sjtu.edu.cn)
Source PublicationSCIENTIFIC REPORTS
2019-03-20
ISSN2045-2322
DOI10.1038/s41598-018-38216-9
Volume9Pages:11
Funding ProjectNational 973 project of China[2011CB504001] ; National Natural Science Foundation major international (regional) joint research project[81220108006] ; NSFC-NHMRC joint research grant[81561128016] ; Shanghai Pujiang Program[17PJ1407500] ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai[2017YQ009]
Funding OrganizationNational 973 project of China ; National 973 project of China ; National Natural Science Foundation major international (regional) joint research project ; National Natural Science Foundation major international (regional) joint research project ; NSFC-NHMRC joint research grant ; NSFC-NHMRC joint research grant ; Shanghai Pujiang Program ; Shanghai Pujiang Program ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai ; National 973 project of China ; National 973 project of China ; National Natural Science Foundation major international (regional) joint research project ; National Natural Science Foundation major international (regional) joint research project ; NSFC-NHMRC joint research grant ; NSFC-NHMRC joint research grant ; Shanghai Pujiang Program ; Shanghai Pujiang Program ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai ; National 973 project of China ; National 973 project of China ; National Natural Science Foundation major international (regional) joint research project ; National Natural Science Foundation major international (regional) joint research project ; NSFC-NHMRC joint research grant ; NSFC-NHMRC joint research grant ; Shanghai Pujiang Program ; Shanghai Pujiang Program ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai ; National 973 project of China ; National 973 project of China ; National Natural Science Foundation major international (regional) joint research project ; National Natural Science Foundation major international (regional) joint research project ; NSFC-NHMRC joint research grant ; NSFC-NHMRC joint research grant ; Shanghai Pujiang Program ; Shanghai Pujiang Program ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordCHAIN FATTY-ACIDS ; ADIPOSE-TISSUE ; INSULIN SENSITIVITY ; GLYCEMIC INDEX ; GLUCOSE ; EXPRESSION ; AMYLOSE ; GLP-1 ; CHOLESTEROL ; CONSUMPTION
AbstractResistant starch (RS) has been reported to reduce body fat in obese mice. However, this effect has not been demonstrated in humans. In this study, we tested the effects of RS in 19 volunteers with normal body weights. A randomized, double-blinded and crossover design clinical trial was conducted. The study subjects were given either 40 g high amylose RS2 or energy-matched control starch with three identical diets per day throughout the study. The effect of RS was evaluated by monitoring body fat, glucose metabolism, gut hormones, gut microbiota, short-chain fatty acids (SCFAs) and metabolites. The visceral and subcutaneous fat areas were significantly reduced following RS intake. Acetate and early-phase insulin, C-peptide and glucagon-like peptide-1 (GLP-1) secretion were increased, and the low-density lipoprotein cholesterol (LDL-C) and blood urea nitrogen (BUN) levels were decreased after the RS intervention. Based on 16S rRNA sequencing, certain gut microbes were significantly decreased after RS supplementation, whereas the genus Ruminococcaceae_UCG-005 showed an increase in abundance. Other potential signatures of the RS intervention included Akkermansia, Ruminococcus_2, Victivallis, and Comamonas. Moreover, the baseline abundance of the genera Streptococcus, Ruminococcus_torques_group, Eubacterium_hallii_group, and Eubacterium_eligens_group was significantly associated with the hormonal and metabolic effects of RS. These observations suggest that a daily intake of 40 g of RS is effective in modulating body fat, SCFAs, early-phase insulin and GLP-1 secretion and the gut microbiota in normal-weight subjects.
Language英语
Funding OrganizationNational 973 project of China ; National 973 project of China ; National Natural Science Foundation major international (regional) joint research project ; National Natural Science Foundation major international (regional) joint research project ; NSFC-NHMRC joint research grant ; NSFC-NHMRC joint research grant ; Shanghai Pujiang Program ; Shanghai Pujiang Program ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai ; National 973 project of China ; National 973 project of China ; National Natural Science Foundation major international (regional) joint research project ; National Natural Science Foundation major international (regional) joint research project ; NSFC-NHMRC joint research grant ; NSFC-NHMRC joint research grant ; Shanghai Pujiang Program ; Shanghai Pujiang Program ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai ; National 973 project of China ; National 973 project of China ; National Natural Science Foundation major international (regional) joint research project ; National Natural Science Foundation major international (regional) joint research project ; NSFC-NHMRC joint research grant ; NSFC-NHMRC joint research grant ; Shanghai Pujiang Program ; Shanghai Pujiang Program ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai ; National 973 project of China ; National 973 project of China ; National Natural Science Foundation major international (regional) joint research project ; National Natural Science Foundation major international (regional) joint research project ; NSFC-NHMRC joint research grant ; NSFC-NHMRC joint research grant ; Shanghai Pujiang Program ; Shanghai Pujiang Program ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai ; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai
WOS IDWOS:000461761200001
PublisherNATURE PUBLISHING GROUP
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/165803
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi, Huating; Xu, Guowang; Jia, Weiping
Affiliation1.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Endocrinol & Metab, Shanghai 200233, Peoples R China
2.Shanghai Clin Ctr Diabet, Shanghai Key Lab Diabet Mellitus, Shanghai 200233, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Dept Med, Shanghai 200025, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Clin Nutr, Shanghai 200233, Peoples R China
7.HKI, Leibniz Inst Nat Prod Res & Infect Biol, Dept Syst Biol & Bioinformat, Beutenbergstr 11a, D-07745 Jena, Germany
8.Univ Hong Kong, Sch Biol Sci, Syst Biol & Bioinformat Grp, Hong Kong, Peoples R China
9.Univ Hong Kong, Dept Microbiol, Hong Kong, Peoples R China
10.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Radiol, Shanghai 200233, Peoples R China
11.Louisiana State Univ Syst, Pennington Biomed Res Ctr, Antioxidant & Gene Regulat Lab, Baton Rouge, LA USA
Recommended Citation
GB/T 7714
Zhang, Lei,Ouyang, Yang,Li, Huating,et al. Metabolic phenotypes and the gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects: a randomized crossover trial[J]. SCIENTIFIC REPORTS,2019,9:11.
APA Zhang, Lei.,Ouyang, Yang.,Li, Huating.,Shen, Li.,Ni, Yueqiong.,...&Jia, Weiping.(2019).Metabolic phenotypes and the gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects: a randomized crossover trial.SCIENTIFIC REPORTS,9,11.
MLA Zhang, Lei,et al."Metabolic phenotypes and the gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects: a randomized crossover trial".SCIENTIFIC REPORTS 9(2019):11.
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