DICP OpenIR
Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells
Cui, Bai1,2; Luo, Yuanyuan1; Tian, Pengfei1; Peng, Fei1; Lu, Jinxin1,3; Yang, Yongliang4; Su, Qitong1; Liu, Bing1; Yu, Jiachuan1; Luo, Xi1; Yin, Liu5; Cheng, Wei1; An, Fan1; He, Bin2; Liang, Dapeng1; Wu, Sijin4; Chu, Peng1; Song, Luyao1; Liu, Xinyu3; Luo, Huandong1; Xu, Jie1; Pan, Yujia1; Wang, Yang1; Li, Dangsheng6; Huang, Peng2; Yang, Qingkai1; Zhang, Lingqiang7; Zhou, Binhua P.8; Liu, Suling9,10; Xu, Guowang3; Lam, Eric W-F11; Kelley, Keith W.12,13; Liu, Quentin1,2
Corresponding AuthorLiu, Quentin(liuq9@mail.sysu.edu.cn)
Source PublicationJOURNAL OF CLINICAL INVESTIGATION
2019-03-01
ISSN0021-9738
DOI10.1172/JCI121685
Volume129Issue:3Pages:1030-1046
Funding ProjectNational Natural Science Foundation of China[81820108024] ; National Natural Science Foundation of China[81630005] ; National Natural Science Foundation of China[81573025] ; National Natural Science Foundation of China[81703091] ; Science and Technology Planning Project of Guangzhou[201604020163] ; Dalian High-level Talent Innovation Program[2016RD12] ; Medical Research Council (MRC)[MR/N012097/1] ; Cancer Research UK (CRUK)[C37/A12011] ; Cancer Research UK (CRUK)[C37/A18784] ; Breast Cancer Now[2012MayPR070] ; Breast Cancer Now[2012NovPhD016] ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC)
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Planning Project of Guangzhou ; Science and Technology Planning Project of Guangzhou ; Dalian High-level Talent Innovation Program ; Dalian High-level Talent Innovation Program ; Medical Research Council (MRC) ; Medical Research Council (MRC) ; Cancer Research UK (CRUK) ; Cancer Research UK (CRUK) ; Breast Cancer Now ; Breast Cancer Now ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Planning Project of Guangzhou ; Science and Technology Planning Project of Guangzhou ; Dalian High-level Talent Innovation Program ; Dalian High-level Talent Innovation Program ; Medical Research Council (MRC) ; Medical Research Council (MRC) ; Cancer Research UK (CRUK) ; Cancer Research UK (CRUK) ; Breast Cancer Now ; Breast Cancer Now ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Planning Project of Guangzhou ; Science and Technology Planning Project of Guangzhou ; Dalian High-level Talent Innovation Program ; Dalian High-level Talent Innovation Program ; Medical Research Council (MRC) ; Medical Research Council (MRC) ; Cancer Research UK (CRUK) ; Cancer Research UK (CRUK) ; Breast Cancer Now ; Breast Cancer Now ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Planning Project of Guangzhou ; Science and Technology Planning Project of Guangzhou ; Dalian High-level Talent Innovation Program ; Dalian High-level Talent Innovation Program ; Medical Research Council (MRC) ; Medical Research Council (MRC) ; Cancer Research UK (CRUK) ; Cancer Research UK (CRUK) ; Breast Cancer Now ; Breast Cancer Now ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC)
WOS SubjectMedicine, Research & Experimental
WOS Research AreaResearch & Experimental Medicine
WOS KeywordSUPPRESSES TUMOR-GROWTH ; THERAPEUTIC TARGET ; HEMATOPOIETIC STEM ; PROTEIN-KINASE ; LACTIC-ACID ; C-MYC ; GLYCOLYSIS ; METASTASIS ; INVASION ; OXAMATE
AbstractChronic stress triggers activation of the sympathetic nervous system and drives malignancy. Using an immunodeficient murine system, we showed that chronic stress-induced epinephrine promoted breast cancer stem-like properties via lactate dehydrogenase A-dependent (LDHA-dependent) metabolic rewiring. Chronic stress-induced epinephrine activated LDHA to generate lactate, and the adjusted pH directed USP28-mediated deubiquitination and stabilization of MYC. The SLUG promoter was then activated by MYC, which promoted development of breast cancer stem-like traits. Using a drug screen that targeted LDHA, we found that a chronic stress-induced cancer stem-like phenotype could be reversed by vitamin C. These findings demonstrated the critical importance of psychological factors in promoting stem-like properties in breast cancer cells. Thus, the LDHA-lowering agent vitamin C can be a potential approach for combating stress-associated breast cancer.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Planning Project of Guangzhou ; Science and Technology Planning Project of Guangzhou ; Dalian High-level Talent Innovation Program ; Dalian High-level Talent Innovation Program ; Medical Research Council (MRC) ; Medical Research Council (MRC) ; Cancer Research UK (CRUK) ; Cancer Research UK (CRUK) ; Breast Cancer Now ; Breast Cancer Now ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Planning Project of Guangzhou ; Science and Technology Planning Project of Guangzhou ; Dalian High-level Talent Innovation Program ; Dalian High-level Talent Innovation Program ; Medical Research Council (MRC) ; Medical Research Council (MRC) ; Cancer Research UK (CRUK) ; Cancer Research UK (CRUK) ; Breast Cancer Now ; Breast Cancer Now ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Planning Project of Guangzhou ; Science and Technology Planning Project of Guangzhou ; Dalian High-level Talent Innovation Program ; Dalian High-level Talent Innovation Program ; Medical Research Council (MRC) ; Medical Research Council (MRC) ; Cancer Research UK (CRUK) ; Cancer Research UK (CRUK) ; Breast Cancer Now ; Breast Cancer Now ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Planning Project of Guangzhou ; Science and Technology Planning Project of Guangzhou ; Dalian High-level Talent Innovation Program ; Dalian High-level Talent Innovation Program ; Medical Research Council (MRC) ; Medical Research Council (MRC) ; Cancer Research UK (CRUK) ; Cancer Research UK (CRUK) ; Breast Cancer Now ; Breast Cancer Now ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC)
WOS IDWOS:000460125800017
PublisherAMER SOC CLINICAL INVESTIGATION INC
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/165839
Collection中国科学院大连化学物理研究所
Corresponding AuthorLiu, Quentin
Affiliation1.Dalian Med Univ, Inst Canc Stem Cell, 9 Western Sect,Lvshun South St, Dalian 116044, Liaoning, Peoples R China
2.Sun Yat Sen Univ, Canc Ctr, State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
4.Dalian Univ Technol, Sch Life Sci & Biotechnol, Ctr Mol Med, Dalian, Peoples R China
5.Dalian Med Univ, Affiliated Hosp 1, Dept Oncol, Dalian, Peoples R China
6.Chinese Acad Sci, Shanghai Informat Ctr Life Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China
7.Beijing Inst Life, Natl Ctr Prot Sci, State Key Lab Prote, Beijing, Peoples R China
8.Univ Kentucky, Coll Med, Markey Canc Ctr, Dept Mol & Cellular Biochem, Lexington, KY USA
9.Fudan Univ, Shanghai Canc Ctr, Shanghai, Peoples R China
10.Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China
11.Imperial Coll London, Dept Surg & Canc, London, England
12.Univ Illinois, Coll Agr Consumer & Environm Sci, Dept Anim Sci, Lab Immunophysiol, Urbana, IL USA
13.Univ Illinois, Coll Med, Dept Pathol, Urbana, IL USA
Recommended Citation
GB/T 7714
Cui, Bai,Luo, Yuanyuan,Tian, Pengfei,et al. Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells[J]. JOURNAL OF CLINICAL INVESTIGATION,2019,129(3):1030-1046.
APA Cui, Bai.,Luo, Yuanyuan.,Tian, Pengfei.,Peng, Fei.,Lu, Jinxin.,...&Liu, Quentin.(2019).Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells.JOURNAL OF CLINICAL INVESTIGATION,129(3),1030-1046.
MLA Cui, Bai,et al."Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells".JOURNAL OF CLINICAL INVESTIGATION 129.3(2019):1030-1046.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Cui, Bai]'s Articles
[Luo, Yuanyuan]'s Articles
[Tian, Pengfei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Cui, Bai]'s Articles
[Luo, Yuanyuan]'s Articles
[Tian, Pengfei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Cui, Bai]'s Articles
[Luo, Yuanyuan]'s Articles
[Tian, Pengfei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.