DICP OpenIR
Facile, rapid one-pot synthesis of multifunctional gold nanoclusters for cell imaging, hydrogen sulfide detection and pH sensing
Gao, Pengfei1; Li, Min1; Zhang, Yan1; Dong, Chuan2; Zhang, Guomei1; Shi, Lihong1; Li, Gao3; Yuan, Mingjian4; Shuang, Shaomin1
Corresponding AuthorZhang, Yan(yanzhang@sxu.edu.cn) ; Yuan, Mingjian(yuanmj@nankai.edu.cn) ; Shuang, Shaomin(smshuang@sxu.edu.cn)
KeywordGold nanoclusters Fluorescence Cell imaging Hydrogen sulfide PH sensor
Source PublicationTALANTA
2019-05-15
ISSN0039-9140
DOI10.1016/j.talanta.2018.12.078
Volume197Pages:1-11
Funding ProjectNational Natural Science Foundation of China[21403135] ; National Natural Science Foundation of China[21575084] ; National Natural Science Foundation of China[21874087] ; National Natural Science Foundation of China[21305082] ; Natural Science Foundation of Shanxi Province[201701D121017] ; Natural Science Foundation of Shanxi Province[201701D221029] ; Natural Science Foundation of Shanxi Province[201701D121019] ; Shanxi Province Hundred Talent Project ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Shanxi Province ; Natural Science Foundation of Shanxi Province ; Shanxi Province Hundred Talent Project ; Shanxi Province Hundred Talent Project ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Shanxi Province ; Natural Science Foundation of Shanxi Province ; Shanxi Province Hundred Talent Project ; Shanxi Province Hundred Talent Project ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Shanxi Province ; Natural Science Foundation of Shanxi Province ; Shanxi Province Hundred Talent Project ; Shanxi Province Hundred Talent Project ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Shanxi Province ; Natural Science Foundation of Shanxi Province ; Shanxi Province Hundred Talent Project ; Shanxi Province Hundred Talent Project ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordFLUORESCENT-PROBE ; METAL NANOCLUSTERS ; INTRACELLULAR PH ; IN-VIVO ; NANOPARTICLES ; REDUCTION ; CHEMISTRY ; CATALYSIS ; SENSOR
AbstractIn this study, we have developed a facile, rapid one-pot strategy for synthesis of orange fluorescent gold nanoclusters (MBISA-AuNCs) at room temperature by using 2-Mercapto-5-benzimidazolesulfonic acid (MBISA) as both reducing and protecting reagent. The prepared AuNCs exhibited prominent advantages including high fluorescent quantum yield, good water solubility, excellent biocompatibility and low toxicity. Based on these superior properties, the AuNCs have been multi-talented applied in cell imaging, hydrogen sulfide detection and pH sensing. Confocal fluorescence imaging showed that the MBISA-AuNCs could enter living cells and distribute in the cytoplasm. Additionally, the obtained AuNCs could visualize H2S fluctuations in living cells without interference of autofluorescence based on their high sensitivity and selectivity detection for H2S with a linear range of 2.7 x 10(-11)-8.5 x 10(-4) M and a detection limit of 0.024 nM. Most strikingly, the AuNCs exhibited strong pH dependent behavior and responded linearly, rapidly and reversibly to minor pH fluctuations within the range of 2.01-12.00. Therefore, the AuNCs could also image pH fluctuations in live cells with negligible autofluorescence and provided a new method of analysis to visualize monitoring wide pH range change in live cells.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Shanxi Province ; Natural Science Foundation of Shanxi Province ; Shanxi Province Hundred Talent Project ; Shanxi Province Hundred Talent Project ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Shanxi Province ; Natural Science Foundation of Shanxi Province ; Shanxi Province Hundred Talent Project ; Shanxi Province Hundred Talent Project ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Shanxi Province ; Natural Science Foundation of Shanxi Province ; Shanxi Province Hundred Talent Project ; Shanxi Province Hundred Talent Project ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Shanxi Province ; Natural Science Foundation of Shanxi Province ; Shanxi Province Hundred Talent Project ; Shanxi Province Hundred Talent Project ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi ; 131 Leading Talents Project of Higher Learning Institutions of Shanxi
WOS IDWOS:000460710200001
PublisherELSEVIER SCIENCE BV
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/165881
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhang, Yan; Yuan, Mingjian; Shuang, Shaomin
Affiliation1.Shanxi Univ, Sch Chem & Chem Engn, 92 Wucheng Rd, Taiyuan, Shanxi, Peoples R China
2.Shanxi Univ, Inst Environm Sci, 92 Wucheng Rd, Taiyuan, Shanxi, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
4.Nankai Univ, Coll Chem, Minist Educ, Key Lab Adv Energy Mat Chem, Tianjin 300071, Peoples R China
Recommended Citation
GB/T 7714
Gao, Pengfei,Li, Min,Zhang, Yan,et al. Facile, rapid one-pot synthesis of multifunctional gold nanoclusters for cell imaging, hydrogen sulfide detection and pH sensing[J]. TALANTA,2019,197:1-11.
APA Gao, Pengfei.,Li, Min.,Zhang, Yan.,Dong, Chuan.,Zhang, Guomei.,...&Shuang, Shaomin.(2019).Facile, rapid one-pot synthesis of multifunctional gold nanoclusters for cell imaging, hydrogen sulfide detection and pH sensing.TALANTA,197,1-11.
MLA Gao, Pengfei,et al."Facile, rapid one-pot synthesis of multifunctional gold nanoclusters for cell imaging, hydrogen sulfide detection and pH sensing".TALANTA 197(2019):1-11.
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