DICP OpenIR
Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation
Zhou, Lina1; Wang, Zhichao1,2; Hu, Chunxiu1; Zhang, Chaoqi3; Kovatcheva-Datchary, Petia1; Yu, Di1,2; Liu, Shasha3; Ren, Feifei3; Wang, Xiaolin1; Li, Yanli1; Hou, Xiaoli1; Piao, Hailong1; Lu, Xin1; Zhang, Yi3; Xu, Guowang1
Corresponding AuthorZhang, Yi(yizhang@zzu.edu.cn) ; Xu, Guowang()
Keywordglioma IDH1 metabolomics lipidomics metabolic reprogramming
Source PublicationJOURNAL OF PROTEOME RESEARCH
2019-03-01
ISSN1535-3893
DOI10.1021/acs.jproteome.8b00663
Volume18Issue:3Pages:960-969
Funding ProjectNational Natural Science Foundation of China[81472374] ; National Natural Science Foundation of China[21505132] ; National Natural Science Foundation of China[21435006] ; [2017YFC0906900]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS SubjectBiochemical Research Methods
WOS Research AreaBiochemistry & Molecular Biology
WOS KeywordISOCITRATE DEHYDROGENASE 1 ; OXIDATIVE STRESS ; R132H MUTATION ; CANCER ; PROFILES ; GROWTH ; CELLS
AbstractMutations in isocitrate dehydrogenase (IDH) 1 are high-frequency events in low-grade glioma and secondary glioblastoma, and IDH1 mutant gliomas are vulnerable to interventions. Metabolic reprogramming is a hallmark of cancer. In this study, comprehensive metabolism investigation of clinical IDH1 mutant glioma specimens was performed to explore its specific metabolic reprogramming in real micro environment. Massive metabolic alterations from glycolysis to lipid metabolism were identified in the IDH1 mutant glioma tissue when compared to IDH1 wild-type glioma. Of note, tricarboxylic acid (TCA) cycle intermediates were in similar levels in both groups, with more pyruvate found entering the TCA cycle in IDH1 mutant glioma. The pool of fatty acyl chains was also reduced, displayed as decreased triglycerides and sphingolipids, although membrane phosphatidyl lipids were not changed. The lower fatty acyl pool may be mediated by the lower protein expression levels of long-chain acyl-CoA synthetase 1 (ACSL1), ACSL4, and very long-chain acyl-CoA synthetase 3 (ACSVL3) in IDH1 mutant glioma. Lower ACSL1 was further found to contribute to the better survival of IDH1 mutant glioma patients based on the The Cancer Genome Atlas (TCGA) RNA sequencing data. Our research provides valuable insights into the tissue metabolism of human IDH1 mutant glioma and unravels new lipid-related targets.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS IDWOS:000460491800014
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/165895
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhang, Yi; Xu, Guowang
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Zhengzhou Univ, Affiliated Hosp 1, Biotherapy Ctr, Zhengzhou 450052, Henan, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Lina,Wang, Zhichao,Hu, Chunxiu,et al. Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation[J]. JOURNAL OF PROTEOME RESEARCH,2019,18(3):960-969.
APA Zhou, Lina.,Wang, Zhichao.,Hu, Chunxiu.,Zhang, Chaoqi.,Kovatcheva-Datchary, Petia.,...&Xu, Guowang.(2019).Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation.JOURNAL OF PROTEOME RESEARCH,18(3),960-969.
MLA Zhou, Lina,et al."Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation".JOURNAL OF PROTEOME RESEARCH 18.3(2019):960-969.
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