DICP OpenIR
Preparation of epoxy-functionalized hierarchically porous hybrid monoliths via free radical polymerization and application in HILIC enrichment of glycopeptides
Ma, Shujuan1,2; Zhang, Luwei1,2; Wang, Shuyue2; Zhang, Haiyang1,2; You, Xin2,3; Ou, Junjie2; Ye, Mingliang2; Wei, Yinmao1
Corresponding AuthorWei, Yinmao(ymwei@nwu.edu.cn)
KeywordHierarchically porous material Hybrid monolith Polyhedral oligomeric silsesquioxanes Hydrophilic interaction chromatography Glycopeptides enrichment
Source PublicationANALYTICA CHIMICA ACTA
2019-06-13
ISSN0003-2670
DOI10.1016/j.aca.2019.01.011
Volume1058Pages:97-106
Funding ProjectNational Natural Science Foundation of China[21775121] ; National Natural Science Foundation of China[21475104] ; Scientific Research Program - Shaanxi Provincial Education Department[17JS134]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Scientific Research Program - Shaanxi Provincial Education Department ; Scientific Research Program - Shaanxi Provincial Education Department ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Scientific Research Program - Shaanxi Provincial Education Department ; Scientific Research Program - Shaanxi Provincial Education Department ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Scientific Research Program - Shaanxi Provincial Education Department ; Scientific Research Program - Shaanxi Provincial Education Department ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Scientific Research Program - Shaanxi Provincial Education Department ; Scientific Research Program - Shaanxi Provincial Education Department
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordHIGHLY SPECIFIC ENRICHMENT ; SELECTIVE ENRICHMENT ; MASS-SPECTROMETRY ; IDENTIFICATION ; GLYCOSYLATION ; EFFICIENT ; GLYCOPROTEOMICS ; SEPARATION ; DESIGN ; MATRIX
AbstractOwing to their multiscale pore size regimes and unique properties, the materials with hierarchically porous structures have become an important family of functional materials in recent years. They have been applied from energy conversion and storage, catalysis, separation to drug delivery, etc. The synthesis of them is difficult by the need to employ multiple templates and take complicated steps. Herein, we successfully prepared epoxy-functionalized hierarchically porous hybrid monoliths (HPHMs) with micro/meso/macro-structures in an easy way. Firstly, a bulk monolithic material was formed via free radical polymerization between polyhedral oligomeric vinylsilsesquioxanes (vinylPOSS) and allyl glycidyl ether (AGE) in the presence of polycaprolactone (PCL). Then PCL was degraded with hydrochloric acid solution, and the epoxy-functionalized HPHM was obtained. This approach was very simple and suitable for large-scale preparation. Hybrid monoliths with different specific surface area (from 5.4 to 636.7 m(2)/g) were prepared by adjusting the mole ratio of vinylPOSS to AGE and the content of PCL. The results of several characterization methods, including nitrogen adsorption/desorption measurements, scanning electron microscopy (SEM) and mercury intrusion porosimetry (MIP), showed that these materials contained not only micropores and mesopores but also macropores. The materials were further modified with penicillamine to be used as hydrophilic interaction chromatography (HILIC) adsorbents for enriching N-glycopeptides in IgG and serum protein tryptic digests. Up to 23 N-glycopeptides were identified from IgG digest, and 385 N-glycopeptides and 283 N-glycosylation sites were identified from human serum digest. (C) 2019 Elsevier B.V. All rights reserved.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Scientific Research Program - Shaanxi Provincial Education Department ; Scientific Research Program - Shaanxi Provincial Education Department ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Scientific Research Program - Shaanxi Provincial Education Department ; Scientific Research Program - Shaanxi Provincial Education Department ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Scientific Research Program - Shaanxi Provincial Education Department ; Scientific Research Program - Shaanxi Provincial Education Department ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Scientific Research Program - Shaanxi Provincial Education Department ; Scientific Research Program - Shaanxi Provincial Education Department
WOS IDWOS:000460376500011
PublisherELSEVIER SCIENCE BV
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/165909
Collection中国科学院大连化学物理研究所
Corresponding AuthorWei, Yinmao
Affiliation1.Northwest Univ, Coll Chem & Mat Sci, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Shaanxi, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Ma, Shujuan,Zhang, Luwei,Wang, Shuyue,et al. Preparation of epoxy-functionalized hierarchically porous hybrid monoliths via free radical polymerization and application in HILIC enrichment of glycopeptides[J]. ANALYTICA CHIMICA ACTA,2019,1058:97-106.
APA Ma, Shujuan.,Zhang, Luwei.,Wang, Shuyue.,Zhang, Haiyang.,You, Xin.,...&Wei, Yinmao.(2019).Preparation of epoxy-functionalized hierarchically porous hybrid monoliths via free radical polymerization and application in HILIC enrichment of glycopeptides.ANALYTICA CHIMICA ACTA,1058,97-106.
MLA Ma, Shujuan,et al."Preparation of epoxy-functionalized hierarchically porous hybrid monoliths via free radical polymerization and application in HILIC enrichment of glycopeptides".ANALYTICA CHIMICA ACTA 1058(2019):97-106.
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