DICP OpenIR
Quantification of bisphenol A and its selected analogs in serum using pre-column derivatization with high-performance liquid chromatography and tandem mass spectrometry
Tan, Dongqin1,2; Jin, Jing1; Wang, Longxing1; He, Xiaolin3; Guo, Cuicui1,2; Dhanjai1; Lu, Xianbo1; Chen, Jiping1
Corresponding AuthorChen, Jiping(chenjp@dicp.ac.cn)
Keywordbisphenol derivatization high-performance liquid chromatography serum tandem mass spectrometry
Source PublicationJOURNAL OF SEPARATION SCIENCE
2019-03-01
ISSN1615-9306
DOI10.1002/jssc.201800847
Volume42Issue:5Pages:991-998
Funding ProjectNational Natural Science Foundation of China[21677143] ; National Natural Science Foundation of China[21475130]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordENDOCRINE DISRUPTING CHEMICALS ; HUMAN PLASMA ; HUMAN URINE ; EXPOSURE ; CHLORIDE ; BLOOD ; MILK
AbstractDue to regulation of the use of bisphenol A, several analogs serving as bisphenol A replacements have drawn substantial attention for their adverse health effects. To investigate their occurrence in humans and identify possible pollution sources, it is necessary to develop a sensitive method for total bisphenols detection. Thus, a method based on enzymolysis and liquid-liquid extraction followed by molecularly imprinted polymer solid-phase extraction and pre-column derivatization with high-performance liquid chromatography and tandem mass spectrometry was proposed. The developed method exhibited superior selectivity and sensitivity. The matrix effect can be eliminated to a great extent. The method detection limits for eight bisphenols were 0.05 similar to 0.19 ng/mL. Satisfactory recoveries (71 similar to 119%) were obtained by spiking bovine serum at three levels (0.8, 8 and, 20 ng/mL). The method was successfully applied to determine total bisphenols in the serum samples of children. Bisphenol A, bisphenol F, bisphenol S, bisphenol B and bisphenol F were detected with concentrations from below the method detection limit to 1.65, 0.45, 0.79, 2.04 and 0.17 ng/mL, respectively. These results indicate that bisphenol A remains the major pollutant among the studied bisphenols in children, whereas threats from bisphenol A analogs should also be monitored.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS IDWOS:000461674900004
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/165917
Collection中国科学院大连化学物理研究所
Corresponding AuthorChen, Jiping
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Dalian Med Univ, Hosp 2, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Tan, Dongqin,Jin, Jing,Wang, Longxing,et al. Quantification of bisphenol A and its selected analogs in serum using pre-column derivatization with high-performance liquid chromatography and tandem mass spectrometry[J]. JOURNAL OF SEPARATION SCIENCE,2019,42(5):991-998.
APA Tan, Dongqin.,Jin, Jing.,Wang, Longxing.,He, Xiaolin.,Guo, Cuicui.,...&Chen, Jiping.(2019).Quantification of bisphenol A and its selected analogs in serum using pre-column derivatization with high-performance liquid chromatography and tandem mass spectrometry.JOURNAL OF SEPARATION SCIENCE,42(5),991-998.
MLA Tan, Dongqin,et al."Quantification of bisphenol A and its selected analogs in serum using pre-column derivatization with high-performance liquid chromatography and tandem mass spectrometry".JOURNAL OF SEPARATION SCIENCE 42.5(2019):991-998.
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