DICP OpenIR
Validation of a HRGC-ECNI/LRMS method to monitor short-chain chlorinated paraffins in human plasma
Xu, Jiazhi1,2; Guo, Weijing3; Wei, Linhuan3; Gao, Yuan1; Zhang, Haijun1; Zhang, Yichi1; Sun, Ming3; Chen, Jiping1
Corresponding AuthorZhang, Haijun(hjzhang@dicp.ac.cn) ; Chen, Jiping(chenjp@dicp.ac.cn)
KeywordShort-chain chlorinated paraffins Sample preparation Quantitative analysis Human plasma
Source PublicationJOURNAL OF ENVIRONMENTAL SCIENCES
2019
ISSN1001-0742
DOI10.1016/j.jes.2018.04.004
Volume75Pages:289-295
Funding ProjectNational Natural Science Foundation of China[21337002] ; National Basic Research Program (973) of China[2015CB453100]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program (973) of China ; National Basic Research Program (973) of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program (973) of China ; National Basic Research Program (973) of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program (973) of China ; National Basic Research Program (973) of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program (973) of China ; National Basic Research Program (973) of China
WOS SubjectEnvironmental Sciences
WOS Research AreaEnvironmental Sciences & Ecology
WOS KeywordHUMAN EXPOSURE ; FOOD-WEB ; SCCPS ; INDUCTION ; BEHAVIOR ; CHINA ; MILK ; AIR
AbstractShort-chain chlorinated paraffins (SCCPs) are produced in high volume and have the high potential to pose a threat to human health. However, little information is available for SCCP contamination in human blood/plasma/serum, mainly due to the difficulty of sample preparation and quantitative analysis. A method using high resolution gas chromatography coupled with electron capture negative ionization low resolution mass spectrometry (HRGC-ECNI/LRMS) was developed and validated to measure SCCPs in human plasma. The pretreatment process included protein denaturation and lipid elimination, liquid-liquid extraction with a mixture of n-hexane/dichloromethane (1: 1, V/V), and cleanup on a multilayer silica column. The blank controls, including procedural blank, vacuum blood collection tube blank, and instrumental blank, were the most pivotal points for the reliable analysis of SCCPs. The average value of procedural blanks was 9.0 ng/g; and the method detection limit (MDL), calculated as the sum of the average procedural blank value and 3 times of the standard deviation of the procedural blanks, was 12.6 ng/g plasma. The validated method was applied to measure the concentrations of the total SCCPs (Sigma SCCPs) in 50 plasma samples from a general population. The measured plasma concentrations of SSCCPs ranged from
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program (973) of China ; National Basic Research Program (973) of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program (973) of China ; National Basic Research Program (973) of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program (973) of China ; National Basic Research Program (973) of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program (973) of China ; National Basic Research Program (973) of China
WOS IDWOS:000459207900027
PublisherSCIENCE PRESS
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/165957
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhang, Haijun; Chen, Jiping
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Dalian Ctr Dis Control & Prevent, Dalian 116021, Peoples R China
Recommended Citation
GB/T 7714
Xu, Jiazhi,Guo, Weijing,Wei, Linhuan,et al. Validation of a HRGC-ECNI/LRMS method to monitor short-chain chlorinated paraffins in human plasma[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2019,75:289-295.
APA Xu, Jiazhi.,Guo, Weijing.,Wei, Linhuan.,Gao, Yuan.,Zhang, Haijun.,...&Chen, Jiping.(2019).Validation of a HRGC-ECNI/LRMS method to monitor short-chain chlorinated paraffins in human plasma.JOURNAL OF ENVIRONMENTAL SCIENCES,75,289-295.
MLA Xu, Jiazhi,et al."Validation of a HRGC-ECNI/LRMS method to monitor short-chain chlorinated paraffins in human plasma".JOURNAL OF ENVIRONMENTAL SCIENCES 75(2019):289-295.
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