DICP OpenIR
The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China
Wu, Haibo1; Wang, Wei2,3; Du, Jun1; Li, Hong2,3; Wang, Huogang2,3; Huang, Liangliang1; Xiang, Hang2,3; Xie, Jing1; Liu, Xiaoli2,3; Li, Heng1; Lin, Wenchu2,3
Corresponding AuthorLin, Wenchu(wenchu@hmfl.ac.cn)
Keywordbreast cancer PIK3CA clinicopathological characteristics prognosis
Source PublicationCANCER MANAGEMENT AND RESEARCH
2019
ISSN1179-1322
DOI10.2147/CMAR.S195351
Volume11Pages:1473-1492
Funding ProjectNational Natural Science Foundation of China[81702954] ; National Natural Science Foundation of China[81372214] ; Key Technologies R&D Programme of Anhui Province[1604a0802103] ; Fundamental Research Funds for the Central Universities[WK9110000042] ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology[2016FXCX006] ; 100-Talent Program of Chinese Academy of Sciences
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences
WOS SubjectOncology
WOS Research AreaOncology
WOS KeywordINTERNATIONAL EXPERT CONSENSUS ; NEOADJUVANT CHEMOTHERAPY ; PRIMARY THERAPY ; HIGH-FREQUENCY ; GENE ; PATHWAY ; ASSOCIATION ; CARCINOMAS ; ROLES ; WOMEN
AbstractPurpose: The mutation status and prognostic value of PIK3CA in breast cancer were widely investigated, which showed significant difference among the patients from vast areas around the world. In this study, the frequency, distribution, bias, and burden of PIK3CA mutations and their relationships with clinicopathologic variables and prognostic significances were investigated in the breast cancer patients from Central China. Materials and methods: Somatic mutations in exon 9 and exon 20 of PIK3CA gene were analyzed using Sanger sequencing combining with targeted next generation sequencing in 494 breast cancer patients from Central China. The correlations between PIK3CA mutations and clinicopathological characteristics and the prognostic values of multiple PIK3CA mutation statuses were evaluated. Results: PIK3CA mutations were found in 38% of the patients and associated with estrogen receptor-positive, progesterone receptor-positive, low Ki67 labeling index, and luminal/human epidermal growth factor receptor 2-enriched subtypes. Meanwhile, the prognosis of the total patients and the patients in old diagnostic age, progesterone receptor-negative, low Ki67 labeling index, and luminal/human epidermal growth factor receptor 2-enriched subgroups was significantly related to PIK3CA mutations. Most interestingly, the distribution, bias, and burden of PIK3CA mutations were correlated with different clinical, pathological, and molecular features as well as distinct prognostic implications in multiple breast cancer subgroups. Conclusion: The frequency, distribution, bias, and burden of PIK3CA mutations were associated with various clinical, pathological, and molecular characteristics in the breast cancer patients from Central China. These different mutation statuses can be used as potential indicators of prognosis in multiple breast cancer subgroups.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences
WOS IDWOS:000458907200001
PublisherDOVE MEDICAL PRESS LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/165995
Collection中国科学院大连化学物理研究所
Corresponding AuthorLin, Wenchu
Affiliation1.Univ Sci & Technol China, Div Life Sci & Med, Affiliated Hosp 1, Dept Pathol, Hefei 230036, Anhui, Peoples R China
2.Chinese Acad Sci, High Magnet Field Lab, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China
3.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Wu, Haibo,Wang, Wei,Du, Jun,et al. The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China[J]. CANCER MANAGEMENT AND RESEARCH,2019,11:1473-1492.
APA Wu, Haibo.,Wang, Wei.,Du, Jun.,Li, Hong.,Wang, Huogang.,...&Lin, Wenchu.(2019).The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China.CANCER MANAGEMENT AND RESEARCH,11,1473-1492.
MLA Wu, Haibo,et al."The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China".CANCER MANAGEMENT AND RESEARCH 11(2019):1473-1492.
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