DICP OpenIR
HPLC with cellulose Tris (3,5-DimethylPhenylcarbamate) chiral stationary phase: Influence of coating times and coating amount on chiral discrimination
Wei, Qiuhong1,2; Su, Hongjiu1; Gao, Diannan1; Wang, Shudong1
Corresponding AuthorSu, Hongjiu(suhj@dicp.ac.cn) ; Wang, Shudong(wangsd@dicp.ac.cn)
Keywordcellulose tris (3,5-dimethylphenylcarbamate) chiral recognition chiral stationary phase enantioseparation high-performance liquid chromatography resolution
Source PublicationCHIRALITY
2019-03-01
ISSN0899-0042
DOI10.1002/chir.23044
Volume31Issue:3Pages:164-173
Funding ProjectYouth Innovation Promotion Association of CAS
Funding OrganizationYouth Innovation Promotion Association of CAS ; Youth Innovation Promotion Association of CAS ; Youth Innovation Promotion Association of CAS ; Youth Innovation Promotion Association of CAS ; Youth Innovation Promotion Association of CAS ; Youth Innovation Promotion Association of CAS ; Youth Innovation Promotion Association of CAS ; Youth Innovation Promotion Association of CAS
WOS SubjectChemistry, Medicinal ; Chemistry, Analytical ; Chemistry, Organic ; Pharmacology & Pharmacy
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; SILICA-GEL ; RESOLUTION ; ENANTIOMERS ; SEPARATION ; TRIS(3,5-DIMETHYLPHENYLCARBAMATE) ; ENANTIOSEPARATION ; DERIVATIVES
AbstractCoating cellulose tris (3,5-dimethylphenylcarbamate) (CDMPC) on silica gels with large pores have been demonstrated as an efficient way for the preparation of chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC). During the process, a number of parameters, including the type of coating solvent, amount of coating, and the method for subsequent solvent removing, have been proved to affect the performance of the resultant CSPs. Coating times and the concentration of coating solution, however, also makes a difference to CSPs' performance by changing the arrangement of cellulose derivatives while remaining the coating amount constant, have much less been studied before, and thereby, were systematically investigated in this work. Results showed that CSPs with more coating times exhibited higher chiral recognition and column efficiency, suggesting that resolution was determined by column efficiency herein. Afterwards, we also investigated the effect of coating amount on the performance of CSPs, and it was shown that the ability of enantio-recognition did not increase all the time as the coating amount; and four of seven racemates achieved best resolution when the coating amount reached to 18.37%. At the end, the reproducibility of CDMPC-coated CSPs were further confirmed by two methods, ie, reprepared the CSP-0.15-3 and reevaluated the effect of coating times.
Language英语
Funding OrganizationYouth Innovation Promotion Association of CAS ; Youth Innovation Promotion Association of CAS ; Youth Innovation Promotion Association of CAS ; Youth Innovation Promotion Association of CAS ; Youth Innovation Promotion Association of CAS ; Youth Innovation Promotion Association of CAS ; Youth Innovation Promotion Association of CAS ; Youth Innovation Promotion Association of CAS
WOS IDWOS:000458827600002
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/166017
Collection中国科学院大连化学物理研究所
Corresponding AuthorSu, Hongjiu; Wang, Shudong
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, 457 Zhongshan Rd, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wei, Qiuhong,Su, Hongjiu,Gao, Diannan,et al. HPLC with cellulose Tris (3,5-DimethylPhenylcarbamate) chiral stationary phase: Influence of coating times and coating amount on chiral discrimination[J]. CHIRALITY,2019,31(3):164-173.
APA Wei, Qiuhong,Su, Hongjiu,Gao, Diannan,&Wang, Shudong.(2019).HPLC with cellulose Tris (3,5-DimethylPhenylcarbamate) chiral stationary phase: Influence of coating times and coating amount on chiral discrimination.CHIRALITY,31(3),164-173.
MLA Wei, Qiuhong,et al."HPLC with cellulose Tris (3,5-DimethylPhenylcarbamate) chiral stationary phase: Influence of coating times and coating amount on chiral discrimination".CHIRALITY 31.3(2019):164-173.
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