DICP OpenIR
Fucosylated Human Milk Oligosaccharides and N-Glycans in the Milk of Chinese Mothers Regulate the Gut Microbiome of Their Breast-Fed Infants during Different Lactation Stages
Bai, Yaqiang1; Tao, Jia2; Zhou, Jiaorui1; Fan, Qingjie1; Liu, Man1; Hu, Yuqi1; Xu, Yao1; Zhang, Lilong1; Yuan, Jieli1; Li, Wenzhe1; Ze, Xiaolei3; Malard, Patrice3; Guo, Zhimou4; Yan, Jingyu4; Li, Ming1
Corresponding AuthorYan, Jingyu(yanjingyu@dicp.ac.cn) ; Li, Ming(vivianmarat@163.com)
KeywordFUT2 HMOs fucosylation gut microbiome milk N-glycans
Source PublicationMSYSTEMS
2018-11-01
ISSN2379-5077
DOI10.1128/mSystems.00206-18
Volume3Issue:6Pages:19
Funding ProjectNational Key Research and Development Program of China[2017YFD0400600] ; China Postdoctoral Science Foundation[2016M601317] ; China Postdoctoral Science Foundation[2018T110225] ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care[2018BINCMCF39] ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care[2016BINCMCF1102] ; Research Foundation from the Department of Education, Liaoning Province, China[L2016003] ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Research Foundation from the Department of Education, Liaoning Province, China ; Research Foundation from the Department of Education, Liaoning Province, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Research Foundation from the Department of Education, Liaoning Province, China ; Research Foundation from the Department of Education, Liaoning Province, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Research Foundation from the Department of Education, Liaoning Province, China ; Research Foundation from the Department of Education, Liaoning Province, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Research Foundation from the Department of Education, Liaoning Province, China ; Research Foundation from the Department of Education, Liaoning Province, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China
WOS SubjectMicrobiology
WOS Research AreaMicrobiology
WOS KeywordALPHA-L-FUCOSIDASES ; BODY SITES ; GLYCOPROTEINS ; DIVERSITY ; STRAINS ; SHAPES ; GROWTH ; GENE ; FUT2 ; CHROMATOGRAPHY
AbstractThe milk glycobiome has a significant impact on the gut microbiota of infants, which plays a pivotal role in health and development. Fucosylated human milk oligosaccharides (HMOs) and N-glycans on milk proteins are beneficial for the development of healthy gut microbiota, and the fucosylation levels of these glycans can be affected by the maternal fucosyltransferase 2 gene (FUT2). Here, we present results of longitudinal research on paired milk and stool samples from 56 Chinese mothers (CMs) and their breast-fed children. Changes of HMOs and fucosylated N-glycans in milk of CMs at different lactation stages were detected, which allowed characterization of the major differences in milk glycans and consequential effects on the gut microbiome of infants according to maternal FUT2 status. Significant differences in the abundance of total and fucosylated HMOs between secretor and nonsecretor CMs were noted, especially during early lactation. Despite a tendency toward decreasing milk protein concentrations, the fucosylation levels of milk N-glycans increased during late lactation. The changes in the levels of fucosylated HMOs and milk N-glycans were highly correlated with the growth of Bifidobacterium spp. and Lactobacillus spp. in the gut of infants during early and later lactation, respectively. Enriched expression of genes encoding glycoside hydrolases, glycosyl transferases, ATP-binding cassette (ABC) transporters, and permeases in infants fed by secretor CMs contributed to the promotion of these bacteria in infants. Our data highlight the important role of fucosylated milk glycans in shaping the gut microbiome of infants and provide a solid foundation for development of "personalized" nutrition for Chinese infants. IMPORTANCE Human milk glycans provide a broad range of carbon sources for gut microbes in infants. Levels of protein glycosylation in human milk vary during lactation and may also be affected by the stages of gestation and lactation and by the secretor status of the mother. This was the first study to evaluate systematically dynamic changes in human milk oligosaccharides and fucosylated N-glycans in the milk of Chinese mothers with different secretor statuses during 6 months of lactation. Given the unique single nucleotide polymorphism site (rs1047781, A385T) on the fucosyltransferase 2 gene among Chinese populations, our report provides a specific insight into the milk glycobiome of Chinese mothers, which may exert effects on the gut microbiota of infants that differ from findings from other study cohorts.
Language英语
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Research Foundation from the Department of Education, Liaoning Province, China ; Research Foundation from the Department of Education, Liaoning Province, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Research Foundation from the Department of Education, Liaoning Province, China ; Research Foundation from the Department of Education, Liaoning Province, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Research Foundation from the Department of Education, Liaoning Province, China ; Research Foundation from the Department of Education, Liaoning Province, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Nutrition and Care of Maternal & Child Research Fund Project of Guangzhou Biostime Institute of Nutrition Care ; Research Foundation from the Department of Education, Liaoning Province, China ; Research Foundation from the Department of Education, Liaoning Province, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China
WOS IDWOS:000455120400013
PublisherAMER SOC MICROBIOLOGY
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/166335
Collection中国科学院大连化学物理研究所
Corresponding AuthorYan, Jingyu; Li, Ming
Affiliation1.Dalian Med Univ, Coll Basic Med Sci, Dalian, Peoples R China
2.Jinzhou Med Univ, Dept Gynaecol & Obstet, Affiliated Hosp 1, Jinzhou, Peoples R China
3.Biostime Guangzhou Hlth Prod Ltd, Guangzhou, Guangdong, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Bai, Yaqiang,Tao, Jia,Zhou, Jiaorui,et al. Fucosylated Human Milk Oligosaccharides and N-Glycans in the Milk of Chinese Mothers Regulate the Gut Microbiome of Their Breast-Fed Infants during Different Lactation Stages[J]. MSYSTEMS,2018,3(6):19.
APA Bai, Yaqiang.,Tao, Jia.,Zhou, Jiaorui.,Fan, Qingjie.,Liu, Man.,...&Li, Ming.(2018).Fucosylated Human Milk Oligosaccharides and N-Glycans in the Milk of Chinese Mothers Regulate the Gut Microbiome of Their Breast-Fed Infants during Different Lactation Stages.MSYSTEMS,3(6),19.
MLA Bai, Yaqiang,et al."Fucosylated Human Milk Oligosaccharides and N-Glycans in the Milk of Chinese Mothers Regulate the Gut Microbiome of Their Breast-Fed Infants during Different Lactation Stages".MSYSTEMS 3.6(2018):19.
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