DICP OpenIR
Single-Cell Proteomics for Cancer Immunotherapy
Li, Linmei1; Yan, Shiqiang1; Lin, Bingcheng1; Shi, Qihui2,3,4; Lu, Yao1
Corresponding AuthorShi, Qihui(qihuishi@fudan.edu.cn) ; Lu, Yao(luyao@dicp.ac.cn)
Source PublicationCANCER NANOTECHNOLOGY
2018
ISSN0065-230X
DOI10.1016/bs.acr.2018.04.006
Volume139Pages:185-207
WOS SubjectOncology
WOS Research AreaOncology
WOS KeywordMULTIPLEXED PROTEIN-ANALYSIS ; FLOW-CYTOMETRY ; MASS CYTOMETRY ; T-CELLS ; CYTOKINE SECRETION ; RESPONSES ; ANTIBODY ; REVEALS ; HETEROGENEITY ; LYMPHOMA
AbstractCancer immunotherapy fights against cancer by modulating the immune response and is delivering encouraging results in clinical treatments. However, it is challenging to achieve durable response in all cancer patients during treatment due to the diversity and dynamic nature of immune system as well as inter-and intratumor heterogeneity. A comprehensive assessment of system immunity and tumor microenvironment is crucial for effective and safe cancer therapy, which can potentially be resolved by single-cell proteomic analysis. Single-cell proteomic technologies enable system-wide profiling of protein levels in a number of single cells within the immune system and tumor microenvironment, and thereby provide direct assessment of the functional state of the immune cells and tumor-immune interaction that could be used to evaluate efficacy of immunotherapy and to improve clinical outcome. In this chapter, we summarized current single-cell proteomic technologies and their applications in cancer immunotherapy.
Language英语
WOS IDWOS:000453659500009
PublisherELSEVIER ACADEMIC PRESS INC
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Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/166413
Collection中国科学院大连化学物理研究所
Corresponding AuthorShi, Qihui; Lu, Yao
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
2.Fudan Univ, Zhongshan Hosp, Minhang Branch, Shanghai, Peoples R China
3.Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China
4.Fudan Univ, Minhang Hosp, Inst Fudan Minhang Acad Hlth Syst, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Li, Linmei,Yan, Shiqiang,Lin, Bingcheng,et al. Single-Cell Proteomics for Cancer Immunotherapy[J]. CANCER NANOTECHNOLOGY,2018,139:185-207.
APA Li, Linmei,Yan, Shiqiang,Lin, Bingcheng,Shi, Qihui,&Lu, Yao.(2018).Single-Cell Proteomics for Cancer Immunotherapy.CANCER NANOTECHNOLOGY,139,185-207.
MLA Li, Linmei,et al."Single-Cell Proteomics for Cancer Immunotherapy".CANCER NANOTECHNOLOGY 139(2018):185-207.
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