DICP OpenIR
Long noncoding RNA MALAT1 suppresses breast cancer metastasis
Kim, Jongchan1; Piao, Hai-Long1,2; Kim, Beom-Jun3; Yao, Fan1; Han, Zhenbo4; Wang, Yumeng5; Xiao, Zhenna1,6; Siverly, Ashley N.1; Lawhon, Sarah E.1; Ton, Baochau N.1; Lee, Hyemin1; Zhou, Zhicheng1; Gan, Boyi1; Nakagawa, Shinichi7; Ellis, Matthew J.3; Liang, Han5; Hung, Mien-Chie4,8,9; You, M. James10; Sun, Yutong4; Ma, Li1,6
Corresponding AuthorMa, Li(lma4@mdanderson.org)
Source PublicationNATURE GENETICS
2018-12-01
ISSN1061-4036
DOI10.1038/s41588-018-0252-3
Volume50Issue:12Pages:1705-+
Funding ProjectUS National Institutes of Health (NIH)[R01CA166051] ; US National Institutes of Health (NIH)[R01CA181029] ; Cancer Prevention and Research Institute of Texas (CPRIT)[RP150319] ; Stand Up To Cancer Innovative Research Grant[403235] ; NIH[R01CA164346] ; NIH[R01CA200703] ; NIH[R01CA175486] ; NIH[U24CA209851] ; NIH[R01CA181196] ; NIH[R01CA190370] ; CPRIT[RP140402] ; National Breast Cancer Foundation Inc. ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; CPRIT grant[RR140033]
Funding OrganizationUS National Institutes of Health (NIH) ; US National Institutes of Health (NIH) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Stand Up To Cancer Innovative Research Grant ; Stand Up To Cancer Innovative Research Grant ; NIH ; NIH ; CPRIT ; CPRIT ; National Breast Cancer Foundation Inc. ; National Breast Cancer Foundation Inc. ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; CPRIT grant ; CPRIT grant ; US National Institutes of Health (NIH) ; US National Institutes of Health (NIH) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Stand Up To Cancer Innovative Research Grant ; Stand Up To Cancer Innovative Research Grant ; NIH ; NIH ; CPRIT ; CPRIT ; National Breast Cancer Foundation Inc. ; National Breast Cancer Foundation Inc. ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; CPRIT grant ; CPRIT grant ; US National Institutes of Health (NIH) ; US National Institutes of Health (NIH) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Stand Up To Cancer Innovative Research Grant ; Stand Up To Cancer Innovative Research Grant ; NIH ; NIH ; CPRIT ; CPRIT ; National Breast Cancer Foundation Inc. ; National Breast Cancer Foundation Inc. ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; CPRIT grant ; CPRIT grant ; US National Institutes of Health (NIH) ; US National Institutes of Health (NIH) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Stand Up To Cancer Innovative Research Grant ; Stand Up To Cancer Innovative Research Grant ; NIH ; NIH ; CPRIT ; CPRIT ; National Breast Cancer Foundation Inc. ; National Breast Cancer Foundation Inc. ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; CPRIT grant ; CPRIT grant
WOS SubjectGenetics & Heredity
WOS Research AreaGenetics & Heredity
WOS KeywordEPITHELIAL-MESENCHYMAL TRANSITION ; COLORECTAL-CANCER ; MAMMARY-TUMORS ; EMERGING ROLES ; YAP ; ACTIVATION ; EXPRESSION ; ONCOGENE ; BINDING ; GROWTH
AbstractMALAT1 has previously been described as a metastasis-promoting long noncoding RNA (lncRNA). We show here, however, that targeted inactivation of the Malat1 gene in a transgenic mouse model of breast cancer, without altering the expression of its adjacent genes, promotes lung metastasis, and that this phenotype can be reversed by genetic add-back of Malat1. Similarly, knockout of MALAT1 in human breast cancer cells induces their metastatic ability, which is reversed by re-expression of Malat1. Conversely, overexpression of Malat1 suppresses breast cancer metastasis in transgenic, xenograft, and syngeneic models. Mechanistically, the MALAT1 lncRNA binds and inactivates the prometastatic transcription factor TEAD, preventing TEAD from associating with its co-activator YAP and target gene promoters. Moreover, MALAT1 levels inversely correlate with breast cancer progression and metastatic ability. These findings demonstrate that MALAT1 is a metastasis-suppressing lncRNA rather than a metastasis promoter in breast cancer, calling for rectification of the model for this highly abundant and conserved lncRNA.
Language英语
Funding OrganizationUS National Institutes of Health (NIH) ; US National Institutes of Health (NIH) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Stand Up To Cancer Innovative Research Grant ; Stand Up To Cancer Innovative Research Grant ; NIH ; NIH ; CPRIT ; CPRIT ; National Breast Cancer Foundation Inc. ; National Breast Cancer Foundation Inc. ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; CPRIT grant ; CPRIT grant ; US National Institutes of Health (NIH) ; US National Institutes of Health (NIH) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Stand Up To Cancer Innovative Research Grant ; Stand Up To Cancer Innovative Research Grant ; NIH ; NIH ; CPRIT ; CPRIT ; National Breast Cancer Foundation Inc. ; National Breast Cancer Foundation Inc. ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; CPRIT grant ; CPRIT grant ; US National Institutes of Health (NIH) ; US National Institutes of Health (NIH) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Stand Up To Cancer Innovative Research Grant ; Stand Up To Cancer Innovative Research Grant ; NIH ; NIH ; CPRIT ; CPRIT ; National Breast Cancer Foundation Inc. ; National Breast Cancer Foundation Inc. ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; CPRIT grant ; CPRIT grant ; US National Institutes of Health (NIH) ; US National Institutes of Health (NIH) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Cancer Prevention and Research Institute of Texas (CPRIT) ; Stand Up To Cancer Innovative Research Grant ; Stand Up To Cancer Innovative Research Grant ; NIH ; NIH ; CPRIT ; CPRIT ; National Breast Cancer Foundation Inc. ; National Breast Cancer Foundation Inc. ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund ; CPRIT grant ; CPRIT grant
WOS IDWOS:000451434400018
PublisherNATURE PUBLISHING GROUP
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/166509
Collection中国科学院大连化学物理研究所
Corresponding AuthorMa, Li
Affiliation1.Univ Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Houston, TX 77030 USA
2.Chinese Acad Sci, Dalian Inst Chem Phys, Sci Res Ctr Translat Med, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
3.Baylor Coll Med, Lester & Sue Smith Breast Ctr, Houston, TX 77030 USA
4.Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA
5.Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA
6.Univ Texas MD Anderson Canc Ctr, UTHlth Grad Sch Biomed Sci, Houston, TX 77030 USA
7.Hokkaido Univ, Fac Pharmaceut Sci, RNA Biol Lab, Sapporo, Hokkaido, Japan
8.China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan
9.China Med Univ, Ctr Mol Med, Taichung, Taiwan
10.Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA
Recommended Citation
GB/T 7714
Kim, Jongchan,Piao, Hai-Long,Kim, Beom-Jun,et al. Long noncoding RNA MALAT1 suppresses breast cancer metastasis[J]. NATURE GENETICS,2018,50(12):1705-+.
APA Kim, Jongchan.,Piao, Hai-Long.,Kim, Beom-Jun.,Yao, Fan.,Han, Zhenbo.,...&Ma, Li.(2018).Long noncoding RNA MALAT1 suppresses breast cancer metastasis.NATURE GENETICS,50(12),1705-+.
MLA Kim, Jongchan,et al."Long noncoding RNA MALAT1 suppresses breast cancer metastasis".NATURE GENETICS 50.12(2018):1705-+.
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