DICP OpenIR
N-Acetylcysteine alleviates gut dysbiosis and glucose metabolic disorder in high-fat diet-fed mice
Zheng, Junping1,2,3,4; Yuan, Xubing2,3,4; Zhang, Chen3,4; Jia, Peiyuan3,4; Jiao, Siming3,4; Zhao, Xiaoming1; Yin, Heng1; Du, Yuguang3,4; Liu, Hongtao3,4,5
Corresponding AuthorLiu, Hongtao(liuhongtao@ipe.ac.cn)
KeywordAkkermansia gut microbiota lipopolysaccharide metabolic syndrome N-acetylcysteine
Source PublicationJOURNAL OF DIABETES
2019
ISSN1753-0393
DOI10.1111/1753-0407.12795
Volume11Issue:1Pages:32-45
Funding ProjectNational Natural Science Foundation of China[31570801] ; National Natural Science Foundation of China[31500747] ; National Natural Science Foundation of China[31672077] ; National Programs for High Technology Research and Development (863 Programs)[2014AA093604] ; CAS Youth Innovation Promotion Association[2015144]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Programs for High Technology Research and Development (863 Programs) ; National Programs for High Technology Research and Development (863 Programs) ; CAS Youth Innovation Promotion Association ; CAS Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Programs for High Technology Research and Development (863 Programs) ; National Programs for High Technology Research and Development (863 Programs) ; CAS Youth Innovation Promotion Association ; CAS Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Programs for High Technology Research and Development (863 Programs) ; National Programs for High Technology Research and Development (863 Programs) ; CAS Youth Innovation Promotion Association ; CAS Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Programs for High Technology Research and Development (863 Programs) ; National Programs for High Technology Research and Development (863 Programs) ; CAS Youth Innovation Promotion Association ; CAS Youth Innovation Promotion Association
WOS SubjectEndocrinology & Metabolism
WOS Research AreaEndocrinology & Metabolism
WOS KeywordMOLECULAR-MECHANISM ; INSULIN-RESISTANCE ; BIOFILM FORMATION ; ACETYL-CYSTEINE ; MICROBIOTA ; OBESITY ; INFLAMMATION ; ASSOCIATION ; BENEFITS ; GROWTH
AbstractBackground: N-Acetylcysteine (NAC), an antioxidative reagent for clinical diseases, shows potential in the treatment of diabetes and other metabolic diseases. However, it is unknown how NAC modulates the gut microbiota of mice with metabolic syndrome. The aim of the present study was to demonstrate the preventive effect of NAC on intestinal dysbiosis and glucose metabolic disorder. Methods: Mice (C57BL/6J strain) were fed either a normal chow diet (NCD), NCD plus NAC, a high-fat diet (HFD), or HFD plus NAC for 5 months, after which glucose levels, circulating endotoxins and key metabolism-related proteins were determined. Fecal samples were analyzed by 16S rRNA sequencing. A novel analysis was performed to predict functional changes in gut microbiota. In addition, Spearman's correlation analysis was performed between metabolic biomarkers and bacterial abundance. Results: Treatment with NAC significantly reversed the glucose intolerance, fasting glucose concentrations, and gains in body weight and plasma endotoxin in HFD-fed mice. Further, NAC upregulated occludin and mucin glycoprotein levels in the proximal colon of HFD-treated mice. Noticeably, NAC promoted the growth of beneficial bacteria (i.e. Akkermansia, Bifidobacterium, Lactobacillus and Allobaculum) and decreased populations of diabetes-related genera, including Desulfovibrio and Blautia. In addition, NAC may affect the metabolic pathways of intestinal bacteria, including lipopolysaccharide biosynthesis, oxidative stress, and bacterial motility. Finally, the modified gut microbiota was closely associated with the metabolic changes in NAC-treated HFD-fed mice. Conclusions: N-Acetylcysteine may be a potential drug to prevent glucose metabolic disturbances by reshaping the structure of the gut microbiota.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Programs for High Technology Research and Development (863 Programs) ; National Programs for High Technology Research and Development (863 Programs) ; CAS Youth Innovation Promotion Association ; CAS Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Programs for High Technology Research and Development (863 Programs) ; National Programs for High Technology Research and Development (863 Programs) ; CAS Youth Innovation Promotion Association ; CAS Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Programs for High Technology Research and Development (863 Programs) ; National Programs for High Technology Research and Development (863 Programs) ; CAS Youth Innovation Promotion Association ; CAS Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Programs for High Technology Research and Development (863 Programs) ; National Programs for High Technology Research and Development (863 Programs) ; CAS Youth Innovation Promotion Association ; CAS Youth Innovation Promotion Association
WOS IDWOS:000451868200006
PublisherWILEY
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/166601
Collection中国科学院大连化学物理研究所
Corresponding AuthorLiu, Hongtao
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Liaoning Prov Key Lab Carbohydrates, Dalian, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Key Lab Biopharmaceut Prod & Formulat Engn, Beijing, Peoples R China
5.Zhengzhou Inst Emerging Ind Technol, Zhengzhou, Henan, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Junping,Yuan, Xubing,Zhang, Chen,et al. N-Acetylcysteine alleviates gut dysbiosis and glucose metabolic disorder in high-fat diet-fed mice[J]. JOURNAL OF DIABETES,2019,11(1):32-45.
APA Zheng, Junping.,Yuan, Xubing.,Zhang, Chen.,Jia, Peiyuan.,Jiao, Siming.,...&Liu, Hongtao.(2019).N-Acetylcysteine alleviates gut dysbiosis and glucose metabolic disorder in high-fat diet-fed mice.JOURNAL OF DIABETES,11(1),32-45.
MLA Zheng, Junping,et al."N-Acetylcysteine alleviates gut dysbiosis and glucose metabolic disorder in high-fat diet-fed mice".JOURNAL OF DIABETES 11.1(2019):32-45.
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