DICP OpenIR
Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma
Li, Ming1; Li, Chuanying1; Ke, Li2; Zhan, Mali1; Cheng, Min3
Corresponding AuthorLi, Ming(aylm123@163.com)
Keywordepidermal growth factor receptor mutation non-small cell lung cancer microinvasive adenocarcinoma molecular subgroup
Source PublicationONCOLOGY LETTERS
2018-12-01
ISSN1792-1074
DOI10.3892/ol.2018.9539
Volume16Issue:6Pages:7057-7067
Funding ProjectNational Natural Science Foundation of China[81602605]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS SubjectOncology
WOS Research AreaOncology
WOS KeywordINTERNATIONAL MULTIDISCIPLINARY CLASSIFICATION ; HEALTH-ORGANIZATION CLASSIFICATION ; TRANSCRIPTION FACTOR-I ; EGFR MUTATION ; OPEN-LABEL ; 1ST-LINE TREATMENT ; GENE-MUTATIONS ; PHASE-III ; CLINICOPATHOLOGICAL FEATURES ; CLINICAL-SIGNIFICANCE
AbstractLung microinvasive adenocarcinoma (MIA) is a newly-defined subtype of early stage non-small cell lung cancer (NSCLC). However, its epidermal growth factor receptor (EGFR) mutation status and clinical significance remain unclear. The present study aimed to determine EGFR mutation characteristics and identify their significance in patients with resected lung MIA. The present study also analyzed clinicopathological differences between EGFR molecular subgroups defined as 19Del and L858R. The present study examined EGFR mutations in 79 consecutive lung MIA resection specimens and compared the differences in clinicopathological features between the EGFR wild-type and mutation groups, as well as between the 19Del and L858R subgroups. EGFR mutations were detected in 60 (75.95%) tumors. The most common mutations were 19Del (28 cases; 35.44%) and L858R (30 cases; 37.97%). Two patients harbored rare mutations and one of them had a concomitant double mutation. EGFR mutations were significantly associated with microinvasion component, thyroid transcription factor 1 (TTF-1) expression, intratumoral fibrosis and inflammatory cell infiltration. Subgroup evaluation indicated that there was a significant association between 19Del and tumor size, maximum diameter of microinvasion, presence of intratumoral fibrosis and inflammatory cell infiltration. Similar associations were observed for the L858R subgroup, and L858R was associated with TTF-1 expression. In particular, 19Del occurred more frequently in MIA with a smaller size, with a smaller microinvasive area, without TTF-1 expression, and lacking intratumoral fibrosis and inflammatory cell infiltration. By contrast, L858R was detected more frequently in MIA with entirely different tumor features. In conclusion, the results of the present study indicated that surgically resected MIA cases harboring different EGFR gene statuses exhibit distinct clinicopathological features. Significant differences in pathological features associated with the tumor microenvironment were identified in MIA with 19Del or L858R mutations. Therefore, the present study proposed that MIA should be classified into molecular subgroups based on EGFR mutation subtypes. The molecular sub-classification should be taken into account for prognostic evaluation and clinical management of MIA.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS IDWOS:000451400400020
PublisherSPANDIDOS PUBL LTD
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/166609
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi, Ming
Affiliation1.Univ Sci & Technol China, Affiliated Hosp 1, Anhui Prov Hosp, Dept Pathol, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China
2.Univ Sci & Technol China, Affiliated Hosp 1, Anhui Prov Hosp, Dept Thorac Surg, Hefei 230001, Anhui, Peoples R China
3.Univ Sci & Technol China, Affiliated Hosp 1, Anhui Prov Hosp, Gerontol Inst Anhui Prov, Hefei 230001, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Li, Ming,Li, Chuanying,Ke, Li,et al. Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma[J]. ONCOLOGY LETTERS,2018,16(6):7057-7067.
APA Li, Ming,Li, Chuanying,Ke, Li,Zhan, Mali,&Cheng, Min.(2018).Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma.ONCOLOGY LETTERS,16(6),7057-7067.
MLA Li, Ming,et al."Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma".ONCOLOGY LETTERS 16.6(2018):7057-7067.
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