DICP OpenIR
Boronic acid-functionalized iron oxide magnetic nanoparticles via distillation-precipitation polymerization and thiol-yne click chemistry for the enrichment of glycoproteins
Bi, Changfen1,2; Zhang, Sitong3; Li, Yiliang1,2; He, Xiwen3; Chen, Langxing3,4; Zhang, Yukui3,5
Corresponding AuthorLi, Yiliang() ; Chen, Langxing(lxchen@nankai.edu.cn)
Source PublicationNEW JOURNAL OF CHEMISTRY
2018-11-07
ISSN1144-0546
DOI10.1039/c8nj01711e
Volume42Issue:21Pages:17331-17338
Funding ProjectNational Natural Science Foundation of China[21475067] ; Natural Science Foundation of Tianjin City[15JCYBJC20600] ; Natural Science Foundation of Tianjin City[18JCQNJC09500] ; CAMS Innovation Fund for Medical Sciences (CIFMS)[2017-I2M-3-019] ; CAMS Innovation Fund for Medical Sciences (CIFMS)[2016-I2M-3-022]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Tianjin City ; Natural Science Foundation of Tianjin City ; CAMS Innovation Fund for Medical Sciences (CIFMS) ; CAMS Innovation Fund for Medical Sciences (CIFMS) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Tianjin City ; Natural Science Foundation of Tianjin City ; CAMS Innovation Fund for Medical Sciences (CIFMS) ; CAMS Innovation Fund for Medical Sciences (CIFMS) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Tianjin City ; Natural Science Foundation of Tianjin City ; CAMS Innovation Fund for Medical Sciences (CIFMS) ; CAMS Innovation Fund for Medical Sciences (CIFMS) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Tianjin City ; Natural Science Foundation of Tianjin City ; CAMS Innovation Fund for Medical Sciences (CIFMS) ; CAMS Innovation Fund for Medical Sciences (CIFMS)
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordTRANSFER RADICAL POLYMERIZATION ; SELECTIVE ENRICHMENT ; TRACE GLYCOPROTEINS ; EFFICIENT APPROACH ; GLYCOSYLATION ; CANCER ; RECOGNITION ; METASTASIS ; COMPOSITES ; CAPTURE
AbstractIn this work, a novel strategy is developed for the fabrication of phenylboronic acid functionalized iron oxide magnetic nanoparticles (MNPs) via distillation-precipitation polymerization and thiol-yne click chemistry. Firstly, silica was coated on the Fe3O4 MNPs using a sol-gel method to obtain Fe3O4@SiO2. Subsequently, the vinyl groups were grated onto the silica-modified Fe3O4 surface using 3-methacryloyloxypropyltrimethoxysilane. Next, alkynyl groups as the clickable sites were modified on the MNPs to obtain the product Fe3O4@pPMA via distillation-precipitation polymerization of the vinyl end groups with propargyl methacrylate, ethylene glycol dimethacrylate. Finally, phenylboronic acid was grafted on the surface of Fe3O4@pPMA via thiol-yne click chemistry. The morphology, structure, and composition of all the synthesized phenylboronic acid functionalized Fe3O4 MNPs (Fe3O4@pPMA-MPBA) were characterized by transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy, X-ray powder diffraction (XRD), vibrating sample magnetometry (VSM), X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA). Three glycoproteins ovalbumin, transferrin, and horseradish peroxidase and two non-glycoproteins lysozyme and horse heart cytochrome are the chosen target proteins and their adsorption performance on Fe3O4@pPMA-MPBA is investigated. The Fe3O4@pPMA-MPBA MNPs exhibited outstanding advantages towards glycoproteins including high adsorption capacity, excellent specificity, repeatability and good enrichment recovery. Furthermore, the Fe3O4@pPMA-MPBA MNPs could efficiently enrich glycoproteins from real egg white samples. This study provides a feasible strategy for the surface functionalization of boronate affinity nanomaterials for the selective isolation and enrichment of glycoproteins.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Tianjin City ; Natural Science Foundation of Tianjin City ; CAMS Innovation Fund for Medical Sciences (CIFMS) ; CAMS Innovation Fund for Medical Sciences (CIFMS) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Tianjin City ; Natural Science Foundation of Tianjin City ; CAMS Innovation Fund for Medical Sciences (CIFMS) ; CAMS Innovation Fund for Medical Sciences (CIFMS) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Tianjin City ; Natural Science Foundation of Tianjin City ; CAMS Innovation Fund for Medical Sciences (CIFMS) ; CAMS Innovation Fund for Medical Sciences (CIFMS) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Tianjin City ; Natural Science Foundation of Tianjin City ; CAMS Innovation Fund for Medical Sciences (CIFMS) ; CAMS Innovation Fund for Medical Sciences (CIFMS)
WOS IDWOS:000448568100017
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/166779
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi, Yiliang; Chen, Langxing
Affiliation1.Peking Union Med Coll, Inst Radiat Med, Tianjin Key Lab Radiat Med & Mol Nucl Med, Tianjin 300192, Peoples R China
2.Chinese Acad Med Sci, Tianjin 300192, Peoples R China
3.Nankai Univ, Tianjin Key Lab Biosensing & Mol Recognit, State Key Lab Med Chem Biol, Res Ctr Analyt Sci,Coll Chem, Tianjin 300071, Peoples R China
4.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Bi, Changfen,Zhang, Sitong,Li, Yiliang,et al. Boronic acid-functionalized iron oxide magnetic nanoparticles via distillation-precipitation polymerization and thiol-yne click chemistry for the enrichment of glycoproteins[J]. NEW JOURNAL OF CHEMISTRY,2018,42(21):17331-17338.
APA Bi, Changfen,Zhang, Sitong,Li, Yiliang,He, Xiwen,Chen, Langxing,&Zhang, Yukui.(2018).Boronic acid-functionalized iron oxide magnetic nanoparticles via distillation-precipitation polymerization and thiol-yne click chemistry for the enrichment of glycoproteins.NEW JOURNAL OF CHEMISTRY,42(21),17331-17338.
MLA Bi, Changfen,et al."Boronic acid-functionalized iron oxide magnetic nanoparticles via distillation-precipitation polymerization and thiol-yne click chemistry for the enrichment of glycoproteins".NEW JOURNAL OF CHEMISTRY 42.21(2018):17331-17338.
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