DICP OpenIR
Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles
Yu, Chang-Bin1; Wang, Jie1,2; Zhou, Yong-Gui1,3
Corresponding AuthorZhou, Yong-Gui(ygzhou@dicp.ac.cn)
Source PublicationORGANIC CHEMISTRY FRONTIERS
2018-10-07
ISSN2052-4129
DOI10.1039/c8qo00710a
Volume5Issue:19Pages:2805-2809
Funding ProjectNational Natural Science Foundation of China[21532006] ; National Natural Science Foundation of China[21690074] ; Dalian Bureau of Science and Technology[2016RD07] ; Strategic Priority Program of the Chinese Academy of Sciences[XDB17020300]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences
WOS SubjectChemistry, Organic
WOS Research AreaChemistry
WOS KeywordHIGHLY ENANTIOSELECTIVE SYNTHESIS ; OXIDATIVE TANDEM CYCLIZATION ; REDUCTIVE AMINATION ; HETEROAROMATIC-COMPOUNDS ; 2,3-DISUBSTITUTED INDOLINES ; KINETIC RESOLUTION ; BRONSTED ACIDS ; ARYL KETONES ; ALKALOIDS ; CATALYSTS
AbstractA concise and enantioselective procedure for the synthesis of optically active indolines has been developed through intramolecular condensation, deprotection and palladium-catalyzed asymmetric hydrogenation in a one-pot process with up to 96% ee. A strong BrOnsted acid played an important role in both the formation of indoles and asymmetric hydrogenation process. This strategy could be scaled-up with excellent reactivity and enantioselectivity.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences
WOS IDWOS:000447950500005
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/166801
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhou, Yong-Gui
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China
Recommended Citation
GB/T 7714
Yu, Chang-Bin,Wang, Jie,Zhou, Yong-Gui. Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles[J]. ORGANIC CHEMISTRY FRONTIERS,2018,5(19):2805-2809.
APA Yu, Chang-Bin,Wang, Jie,&Zhou, Yong-Gui.(2018).Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles.ORGANIC CHEMISTRY FRONTIERS,5(19),2805-2809.
MLA Yu, Chang-Bin,et al."Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles".ORGANIC CHEMISTRY FRONTIERS 5.19(2018):2805-2809.
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