DICP OpenIR
Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces
Cai, Xiaoming1; Dong, Jun2; Liu, Jing3; Zheng, Huizhen1; Kaweeteerawat, Chitrada4; Wang, Fangjun3; Ji, Zhaoxia5,6; Li, Ruibin1
Corresponding AuthorJi, Zhaoxia(zji@cnsi.ucla.edu) ; Li, Ruibin(liruibin@suda.edu.cn)
Source PublicationNATURE COMMUNICATIONS
2018-10-24
ISSN2041-1723
DOI10.1038/s41467-018-06869-9
Volume9Pages:12
Funding ProjectNational Natural Science Foundation of China[31671032] ; National Natural Science Foundation of China[21804096] ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province[17KJA310003] ; Natural Science Foundation of Jiangsu Province[BK20180840] ; Suzhou Science and Technology Development Project[SYS201715] ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Suzhou Science and Technology Development Project ; Suzhou Science and Technology Development Project ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Suzhou Science and Technology Development Project ; Suzhou Science and Technology Development Project ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Suzhou Science and Technology Development Project ; Suzhou Science and Technology Development Project ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Suzhou Science and Technology Development Project ; Suzhou Science and Technology Development Project ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordOXIDATIVE STRESS ; OXIDE NANOPARTICLES ; PULMONARY TOXICITY ; TUMOR-GROWTH ; BAND-GAP ; IN-VITRO ; CELLS ; PROTEIN ; MIGRATION ; SPECTROSCOPY
AbstractIncreasing concerns over the possible risks of nanotechnology necessitates breakthroughs in structure-activity relationship (SAR) analyses of engineered nanomaterials (ENMs) at nano-bio interfaces. However, current nano-SARs are often based on univariate assessments and fail to provide tiered views on ENM-induced bio-effects. Here we report a multi-hierarchical nano-SAR assessment for a representative ENM, Fe2O3, by metabolomics and proteomics analyses. The established nano-SAR profile allows the visualizing of the contributions of seven basic properties of Fe2O3 to its diverse bio-effects. For instance, although surface reactivity is responsible for Fe2O3-induced cell migration, the inflammatory effects of Fe2O3 are determined by aspect ratio (nanorods) or surface reactivity (nanoplates). These nano-SARs are examined in THP-1 cells and animal lungs, which allow us to decipher the detailed mechanisms including NLRP3 inflammasome pathway and monocyte chemoattractant protein-1-dependent signaling. This study provides more insights for nano-SARs, and may facilitate the tailored design of ENMs to render them desired bio-effects.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Suzhou Science and Technology Development Project ; Suzhou Science and Technology Development Project ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Suzhou Science and Technology Development Project ; Suzhou Science and Technology Development Project ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Suzhou Science and Technology Development Project ; Suzhou Science and Technology Development Project ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Suzhou Science and Technology Development Project ; Suzhou Science and Technology Development Project ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
WOS IDWOS:000448104800005
PublisherNATURE PUBLISHING GROUP
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/166805
Collection中国科学院大连化学物理研究所
Corresponding AuthorJi, Zhaoxia; Li, Ruibin
Affiliation1.Soochow Univ, State Key Lab Radiat Med & Protect, Sch Publ Hlth,Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiol Med,Jiangsu Higher, Suzhou 215123, Jiangsu, Peoples R China
2.Wuhan Acad Agr Sci, Wuhan 430000, Hubei, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
4.NSTDA, Natl Nanotechnol Ctr NANOTEC, Klong Nueng 12120, Thailand
5.Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA
6.Living Proof Inc, Cambridge, MA 02142 USA
Recommended Citation
GB/T 7714
Cai, Xiaoming,Dong, Jun,Liu, Jing,et al. Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces[J]. NATURE COMMUNICATIONS,2018,9:12.
APA Cai, Xiaoming.,Dong, Jun.,Liu, Jing.,Zheng, Huizhen.,Kaweeteerawat, Chitrada.,...&Li, Ruibin.(2018).Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces.NATURE COMMUNICATIONS,9,12.
MLA Cai, Xiaoming,et al."Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces".NATURE COMMUNICATIONS 9(2018):12.
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