DICP OpenIR
Current and future perspectives of functional metabolomics in disease studies-A review
Yan, Min1,2,3; Xu, Guowang1,3
Corresponding AuthorXu, Guowang(xugw@dicp.ac.cn)
KeywordFunctional metabolomics Metabolomics Biological platform Cell metabolism Mass spectrometry
Source PublicationANALYTICA CHIMICA ACTA
2018-12-11
ISSN0003-2670
DOI10.1016/j.aca.2018.04.006
Volume1037Pages:41-54
Funding ProjectNational Key Research and Development Program of China[2017YFC0906900] ; National Key Research and Development Program of China[2016YFC0903302] ; National Natural Science Foundation of China[81472374] ; National Natural Science Foundation of China[21435006] ; innovation program of science and research from the DICP, CAS[DICP TMSR201601]
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordCHROMATOGRAPHY-MASS-SPECTROMETRY ; CHAIN AMINO-ACIDS ; METABOLITE IDENTIFICATION APPLICATION ; ISOTOPE RESOLVED METABOLOMICS ; GC/MS-BASED METABOLOMICS ; RATIO OUTLIER ANALYSIS ; NMR-BASED METABOLOMICS ; LABELING LC-MS ; LIQUID-CHROMATOGRAPHY ; TARGETED METABOLOMICS
AbstractFunctional metabolomics is a new concept, which studies the functions of metabolites and related enzymes focused on metabolomics. It overcomes the shortcomings of traditional discovery metabolomics of mainly relying on literatures for biological interpretation. Functional metabolomics has many advantages. Firstly, the functional roles of metabolites and related metabolic enzymes are focused. Secondly, the in vivo and in vitro experiments are conducted to validate the metabolomics findings, therefore, increasing the reliability of metabolomics study and producing the new knowledge. Thirdly, functional metabolomics can be used by biologists to investigate functions of metabolites, and related genes and proteins. In this review, we summarize the analytical, biological and clinical platforms used in functional metabolomics studies. Recent progresses of functional metabolomics in cancer, metabolic diseases and biological phenotyping are reviewed, and future development is also predicted. Because of the tremendous advantages of functional metabolomics, it will have a bright future. (c) 2018 Elsevier B.V. All rights reserved.
Language英语
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS
WOS IDWOS:000446225000005
PublisherELSEVIER SCIENCE BV
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Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/166839
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu, Guowang
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Sci Res Ctr Translat Med, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yan, Min,Xu, Guowang. Current and future perspectives of functional metabolomics in disease studies-A review[J]. ANALYTICA CHIMICA ACTA,2018,1037:41-54.
APA Yan, Min,&Xu, Guowang.(2018).Current and future perspectives of functional metabolomics in disease studies-A review.ANALYTICA CHIMICA ACTA,1037,41-54.
MLA Yan, Min,et al."Current and future perspectives of functional metabolomics in disease studies-A review".ANALYTICA CHIMICA ACTA 1037(2018):41-54.
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