DICP OpenIR
Oriented surface epitope imprinted polymer-based quartz crystal microbalance sensor for cytochrome c
Ma, Xiao-Tong1; He, Xi-Wen1; Li, Wen-You1,2; Zhang, Yu-Kui1,3
Corresponding AuthorLi, Wen-You(wyli@nankai.edu.cn)
KeywordQuartz crystal microbalance sensor Chemosensing Protein recognition Oriented epitope imprinted polymers Reverse microemulsion polymerization
Source PublicationTALANTA
2019
ISSN0039-9140
DOI10.1016/j.talanta.2018.08.079
Volume191Pages:222-228
Funding ProjectNational Natural Science Foundation of China[21275078] ; National Natural Science Foundation of China[21475069] ; National Natural Science Foundation of China[21775077] ; Tianjin Natural Science Foundation[16JCZDJC37200]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordSELECTIVE DETERMINATION ; NANOPARTICLES ; PROTEIN ; RECOGNITION ; AFFINITY ; PERSPECTIVES ; NANOSENSOR ; RECEPTOR ; FILM
AbstractA quartz crystal microbalance (QCM) sensor for detecting cytochrome c based on an oriented surface epitope imprinted polymer was fabricated in this paper. By using the palmitic acid-modified epitope of cytochrome c as the template and the 3-aminopropyltriethoxysilane as the monomer, we prepared a new oriented surface epitope imprinted polymer by the reverse microemulsion polymerization. The prepared oriented imprinted polymer had better imprinting effect than the non-oriented imprinted polymer. And compared to previous studies, this polymerization method is simple and could be carried out at room temperature in the presence of oxygen, under regular atmospheric conditions. Then, by combining the advantages of molecularly imprinted polymers and QCM sensors, we used the prepared polymer to establish a QCM sensor. The described sensor showed good sensitivity and selectivity towards cytochrome c. The linear range was from 0.005 mu g mL(-1) to 0.050 mu g mL(-1) and the detection limit was 3.6 ng mL(-1) which is lower than most of previous works. Besides, it could be used for real sample analysis and had satisfactory reproducibility and accuracy. This work proposed a new way of fabricating oriented surface epitope imprinted polymers-based QCM sensors for selectively detecting proteins at very low concentrations.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation
WOS IDWOS:000447481600029
PublisherELSEVIER SCIENCE BV
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/166859
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi, Wen-You
Affiliation1.Nankai Univ, Tianjin Key Lab Biosensing & Mol Recognit, Coll Chem, Res Ctr Analyt Sci,State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Ma, Xiao-Tong,He, Xi-Wen,Li, Wen-You,et al. Oriented surface epitope imprinted polymer-based quartz crystal microbalance sensor for cytochrome c[J]. TALANTA,2019,191:222-228.
APA Ma, Xiao-Tong,He, Xi-Wen,Li, Wen-You,&Zhang, Yu-Kui.(2019).Oriented surface epitope imprinted polymer-based quartz crystal microbalance sensor for cytochrome c.TALANTA,191,222-228.
MLA Ma, Xiao-Tong,et al."Oriented surface epitope imprinted polymer-based quartz crystal microbalance sensor for cytochrome c".TALANTA 191(2019):222-228.
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