DICP OpenIR
Recent advances in using mass spectrometry for mitochondrial metabolomics and lipidomics - A review
Liu, Xinyu; Xu, Guowang
Corresponding AuthorXu, Guowang(xugw@dicp.ac.cn)
KeywordMitochondria Metabolomics Lipidomics Mass spectrometry Metabolic profiling
Source PublicationANALYTICA CHIMICA ACTA
2018-12-11
ISSN0003-2670
DOI10.1016/j.aca.2017.11.080
Volume1037Pages:3-12
Funding ProjectNational Key Research and Development Program of China[2017YFC0906900] ; National Key Research and Development Program of China[2016YFC0903302] ; National Natural Science Foundation of China[21705147] ; National Natural Science Foundation of China[21435006] ; innovation program of science and research from the DICP, CAS[DICP TMSR201601]
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordSOLID-PHASE MICROEXTRACTION ; RAT-LIVER MITOCHONDRIA ; HEPATOCELLULAR-CARCINOMA ; TARGETED METABOLOMICS ; BRAIN MITOCHONDRIA ; SHOTGUN LIPIDOMICS ; BIOLOGICAL SAMPLES ; POTENTIAL BIOMARKERS ; FUNCTIONAL GENOMICS ; INTACT MITOCHONDRIA
AbstractMetabolomics and lipidomics generally targets a huge number of intermediate and end products of cellular metabolism in body fluids, tissues, and cells etc. At present, mass spectrometry (MS) based metabolic or lipid profiling of routine biological specimens including the whole cells, tissues, plasma, serum and urine etc., can cover hundreds of metabolites or lipid species in one analysis, which has qualified deep elucidation of global metabolic and lipid networks. Mitochondria are important intracellular organelles and many critical biochemical reactions occur here, they provide building block for new cells, control redox balance, participate in apoptosis and behave as a signalling platform. Evidence suggests high prevalence of mitochondrial dysfunction occurs in a variety of cancers and other diseases, thus there is an urgent demand for investigating and clarifying mitochondrial metabolic and lipid alterations induced by diseases. Nevertheless, mitochondria contribute a small fraction to cellular contents, profiling of whole cell is probably unsuitable for monitoring alterations in mitochondria. Therefore, metabolomics and lipidomics analyses specially for mitochondria are necessary to understand disturbed metabolic and lipid pathways induced by environment and diseases. However, methods for comprehensively profiling metabolites and lipids in mitochondria have been limited at present. This review summarizes the current states and progress of MS-based mitochondrial metabolomics and lipidomics study. Details of mitochondrial isolation procedure, analytical methods and their applications are described. The challenges and opportunities are also given. (c) 2017 Elsevier B.V. All rights reserved.
Language英语
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS
WOS IDWOS:000446225000002
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/166877
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu, Guowang
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Liu, Xinyu,Xu, Guowang. Recent advances in using mass spectrometry for mitochondrial metabolomics and lipidomics - A review[J]. ANALYTICA CHIMICA ACTA,2018,1037:3-12.
APA Liu, Xinyu,&Xu, Guowang.(2018).Recent advances in using mass spectrometry for mitochondrial metabolomics and lipidomics - A review.ANALYTICA CHIMICA ACTA,1037,3-12.
MLA Liu, Xinyu,et al."Recent advances in using mass spectrometry for mitochondrial metabolomics and lipidomics - A review".ANALYTICA CHIMICA ACTA 1037(2018):3-12.
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