DICP OpenIR
LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling
Sang, Ling-jie1; Ju, Huai-qiang2; Liu, Guang-ping1,11; Tian, Tian2; Ma, Guo-lin8; Lu, Yun-xin2; Liu, Ze-xian2; Pan, Ruo-lang1; Li, Rui-hua1; Piao, Hai-long5; Marks, Jeffrey R.6; Yang, Luo-jia1; Yan, Qingfeng1; Wang, Wenqi7; Shao, Jianzhong1; Zhou, Yubin8; Zhou, Tianhua3,4; Lin, Aifu1,9,10
Corresponding AuthorLin, Aifu(linaifu@zju.edu.cn)
Source PublicationMOLECULAR CELL
2018-10-04
ISSN1097-2765
DOI10.1016/j.molcel.2018.08.014
Volume72Issue:1Pages:71-+
Funding ProjectNational Natural Science Foundation of China[91740205] ; National Natural Science Foundation of China[81672791] ; National Natural Science Foundation of China[81872300] ; National Natural Science Foundation of China[81602137] ; National Natural Science Foundation of China[31571299] ; National Natural Science Foundation of China[31771398] ; Stem Cell and Translational Research ; National Key Research and Development Program of China[2016YFA0101001] ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China[LR18C060002]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Stem Cell and Translational Research ; Stem Cell and Translational Research ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Stem Cell and Translational Research ; Stem Cell and Translational Research ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Stem Cell and Translational Research ; Stem Cell and Translational Research ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Stem Cell and Translational Research ; Stem Cell and Translational Research ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS KeywordKAPPA-B PATHWAY ; CELL-TRANSFORMATION ; GLUCOSE-METABOLISM ; BREAST-CANCER ; INCRNA ; HIPPO ; RESISTANCE
AbstractCancer cells entail metabolic adaptation and microenvironmental remodeling to survive and progress. Both calcium (Ca2+) flux and Ca2+-dependent signaling play a crucial role in this process, although the underlying mechanism has yet to be elucidated. Through RNA screening, we identified one long noncoding RNA (lncRNA) named CamK-A (lncRNA for calcium-dependent kinase activation) in tumorigenesis. CamK-A is highly expressed in multiple human cancers and involved in cancer microenvironment remodeling via activation of Ca2+-triggered signaling. Mechanistically, CamK-A activates Ca2+/calmodulin-dependent kinase PNCK, which in turn phosphorylates I kappa B alpha and triggers calcium-dependent nuclear factor KB (NF-kappa B) activation. This regulation results in the tumor microenvironment remodeling, including macrophage recruitment, angiogenesis, and tumor progression. Notably, our human-patient-derived xenograft (PDX) model studies demonstrate that targeting CamK-A robustly impaired cancer development. Clinically, CamK-A expression coordinates with the activation of CaMK-NF-kappa B axis, and its high expression indicates poor patient survival rate, suggesting its role as a potential biomarker and therapeutic target.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Stem Cell and Translational Research ; Stem Cell and Translational Research ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Stem Cell and Translational Research ; Stem Cell and Translational Research ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Stem Cell and Translational Research ; Stem Cell and Translational Research ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Stem Cell and Translational Research ; Stem Cell and Translational Research ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China
WOS IDWOS:000446317300009
PublisherCELL PRESS
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/166935
Collection中国科学院大连化学物理研究所
Corresponding AuthorLin, Aifu
Affiliation1.Zhejiang Univ, Coll Life Sci, Hangzhou 310058, Zhejiang, Peoples R China
2.Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China
3.Zhejiang Univ, Sch Med, Dept Cell Biol, Hangzhou 310058, Zhejiang, Peoples R China
4.Zhejiang Univ, Sch Med, Program Mol Cell Biol, Hangzhou 310058, Zhejiang, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China
6.Duke Univ, Sch Med, Div Surg Sci, Dept Surg, Durham, NC 27710 USA
7.Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA
8.Texas A&M Univ, Hlth Sci Ctr, Inst Biosci & Technol, Ctr Translat Canc Res, Houston, TX 77030 USA
9.Key Lab Cell & Gene Engn Zhejiang Prov, Hangzhou 310058, Zhejiang, Peoples R China
10.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Hangzhou 310058, Zhejiang, Peoples R China
11.Yanan Univ, Coll Life Sci, Yanan 716000, Shaanxi, Peoples R China
Recommended Citation
GB/T 7714
Sang, Ling-jie,Ju, Huai-qiang,Liu, Guang-ping,et al. LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling[J]. MOLECULAR CELL,2018,72(1):71-+.
APA Sang, Ling-jie.,Ju, Huai-qiang.,Liu, Guang-ping.,Tian, Tian.,Ma, Guo-lin.,...&Lin, Aifu.(2018).LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling.MOLECULAR CELL,72(1),71-+.
MLA Sang, Ling-jie,et al."LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling".MOLECULAR CELL 72.1(2018):71-+.
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