DICP OpenIR
Plasma bile acid changes in type 2 diabetes correlated with insulin secretion in two-step hyperglycemic clamp
Wang, Shujie1; Deng, Yuying1; Xie, Xiaoyan1; Ma, Jing2; Xu, Min1; Zhao, Xinjie3; Gu, Weiqiong1; Hong, Jie1; Wang, Weiqing1; Xu, Guowang3; Ning, Guang1; Gu, Yanyun1; Zhang, Yifei1
Corresponding AuthorGu, Yanyun(gyy11251@rjh.com.cn) ; Zhang, Yifei(feifei-a@163.com)
Keywordbile acid hyperglycemic clamp insulin secretion type 2 diabetes mellitus
Source PublicationJOURNAL OF DIABETES
2018-11-01
ISSN1753-0393
DOI10.1111/1753-0407.12771
Volume10Issue:11Pages:874-885
Funding ProjectNational Key R&D Program of China[2016YFC0901200] ; National Basic Research Program of China[2015CB5536003] ; National Nature Science Foundation of China[81621061] ; National Nature Science Foundation of China[81670761]
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China
WOS SubjectEndocrinology & Metabolism
WOS Research AreaEndocrinology & Metabolism
WOS KeywordBETA-CELL FUNCTION ; URSODEOXYCHOLIC ACID ; GLUCOSE-TOLERANCE ; METABOLISM ; SENSITIVITY ; OBESITY ; ACTIVATION ; RESISTANCE ; MICROBIOTA ; PHENOTYPE
AbstractBackground: Bile acids (BAs) conduct crucial signals in human metabolism. Correlations between changes in plasma BA concentrations, insulin secretion defects, and progression of type 2 diabetes mellitus (T2DM) in humans have not been sufficiently investigated. This study explored the trajectories of changes in human plasma BA concentrations and their association with insulin secretion dynamics during a two-step hyperglycemic clamp. Methods: Eleven healthy subjects with normal glucose tolerance (NGT) and 33 drug-naive T2DM subjects were enrolled in the study. The two-step hyperglycemic clamp consisted of a classic clamp as Step 1 with fasting, followed by a Step 2 clamp after ingestion of a carbohydrate meal, illustrating basal and incretin-amplified insulin responses to glucose. Plasma BA were assayed using liquid chromatography-tandem mass spectrometry. Nine T2DM subjects were followed-up, and the two-step clamp was repeated after 3 months sulfonylurea treatment. Results: Ursodeoxycholic acid (UDCA) was lower and lithocholic acid (LCA) and taurocholic acid (TCA) were higher in T2DM compared with NGT subjects. The dynamics of plasma UDCA concentrations and the UDCA/LCA ratio was positively correlated with insulin secretion in T2DM subjects and were corrected after treatment. Moreover, fasting ratios of UDCA/LCA and unconjugated/conjugated BAs were correlated with the first phase of insulin secretion in T2DM subjects. Conclusion: The abnormal BA composition in T2DM subjects and its correlation with insulin secretion during the clamp suggest an interaction between BA signals and insulin secretion capacity, and the potential to use fasting plasma BA composition indices to predict and evaluate the progression and prognosis of T2DM.
Language英语
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China
WOS IDWOS:000446325600008
PublisherWILEY
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/166939
Collection中国科学院大连化学物理研究所
Corresponding AuthorGu, Yanyun; Zhang, Yifei
Affiliation1.Shanghai Jiao Tong Univ, Shanghai Inst Endocrine & Metab Dis, Ruijin Hosp,State Key Lab Med Genom, Shanghai Natl Res Ctr Endocrine & Metab Dis,Sch M, Shanghai, Peoples R China
2.Shanghai Jiao Tong Univ, Dept Endocrinol, Med Sch, Renji Hosp, 10th Bldg,197 RuiJin Er Rd, Shanghai 200025, Peoples R China
3.Chinese Acad Sci, Natl Chromatog Res & Anal Ctr, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Wang, Shujie,Deng, Yuying,Xie, Xiaoyan,et al. Plasma bile acid changes in type 2 diabetes correlated with insulin secretion in two-step hyperglycemic clamp[J]. JOURNAL OF DIABETES,2018,10(11):874-885.
APA Wang, Shujie.,Deng, Yuying.,Xie, Xiaoyan.,Ma, Jing.,Xu, Min.,...&Zhang, Yifei.(2018).Plasma bile acid changes in type 2 diabetes correlated with insulin secretion in two-step hyperglycemic clamp.JOURNAL OF DIABETES,10(11),874-885.
MLA Wang, Shujie,et al."Plasma bile acid changes in type 2 diabetes correlated with insulin secretion in two-step hyperglycemic clamp".JOURNAL OF DIABETES 10.11(2018):874-885.
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