DICP OpenIR
Gold Nanorod Photothermal Therapy Alters Cell Junctions and Actin Network in Inhibiting Cancer Cell Collective Migration
Wu, Yue1; Ali, Moustafa R. K.1; Dong, Bin2; Han, Tiegang1; Chen, Kuangcai2; Chen, Jin3,6; Tang, Yan4,5; Fang, Ning2; Wang, Fangjun3; El-Sayed, Mostafa A.1
Corresponding AuthorFang, Ning(nfang@gsu.edu) ; Wang, Fangjun(wangfj@dicp.ac.cn) ; El-Sayed, Mostafa A.(melsayed@gatech.edu)
Keywordcollective cancer cell migration metastasis gold nanorods plasmonic photothermal therapy phosphoproteomics STORM super-resolution microscopy
Source PublicationACS NANO
2018-09-01
ISSN1936-0851
DOI10.1021/acsnano.8b04128
Volume12Issue:9Pages:9279-9290
Funding ProjectNational Science Foundation Division of Chemistry (CHE)[1608801] ; National Natural Science Foundation of China[21675152] ; Youth Innovation Promotion Association CAS[2014164] ; NIH[1R01GM115763]
Funding OrganizationNational Science Foundation Division of Chemistry (CHE) ; National Science Foundation Division of Chemistry (CHE) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Youth Innovation Promotion Association CAS ; NIH ; NIH ; National Science Foundation Division of Chemistry (CHE) ; National Science Foundation Division of Chemistry (CHE) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Youth Innovation Promotion Association CAS ; NIH ; NIH ; National Science Foundation Division of Chemistry (CHE) ; National Science Foundation Division of Chemistry (CHE) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Youth Innovation Promotion Association CAS ; NIH ; NIH ; National Science Foundation Division of Chemistry (CHE) ; National Science Foundation Division of Chemistry (CHE) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Youth Innovation Promotion Association CAS ; NIH ; NIH
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS KeywordTIGHT JUNCTIONS ; BREAST-CANCER ; N-CADHERIN ; QUANTITATIVE PROTEOMICS ; MECHANICAL-PROPERTIES ; ALPHA-CATENIN ; IN-VITRO ; ADHESION ; CYTOSKELETON ; NANOPARTICLES
AbstractMost cancer-related deaths come from metastasis. It was recently discovered that nanoparticles could inhibit cancer cell migration. Whereas most researchers focus on single-cell migration, the effect of nanoparticle treatment on collective cell migration has not been explored. Collective migration occurs commonly in many types of cancer metastasis, where a group of cancer cells move together, which requires the contractility of the cytoskeleton filaments and the connection of neighboring cells by the cell junction proteins. Here, we demonstrate that gold nanorods (AuNRs) and the introduction of near-infrared light could inhibit the cancer cell collective migration by altering the actin filaments and cell junctions with significantly triggered phosphorylation changes of essential proteins, using mass spectrometry-based phosphoproteomics. Further observation using super-resolution stochastic optical reconstruction microscopy (STORM) showed the actin cytoskeleton filament bundles were disturbed, which is difficult to differentiate under a normal fluorescence microscope. The decreased expression level of N-cadherin junctions and morphological changes of tight junction protein zonula occludens 2 were also observed. All of these results indicate possible functions of the AuNR treatments in regulating and remodeling the actin filaments and cell junction proteins, which contribute to decreasing cancer cell collective migration.
Language英语
Funding OrganizationNational Science Foundation Division of Chemistry (CHE) ; National Science Foundation Division of Chemistry (CHE) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Youth Innovation Promotion Association CAS ; NIH ; NIH ; National Science Foundation Division of Chemistry (CHE) ; National Science Foundation Division of Chemistry (CHE) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Youth Innovation Promotion Association CAS ; NIH ; NIH ; National Science Foundation Division of Chemistry (CHE) ; National Science Foundation Division of Chemistry (CHE) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Youth Innovation Promotion Association CAS ; NIH ; NIH ; National Science Foundation Division of Chemistry (CHE) ; National Science Foundation Division of Chemistry (CHE) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Youth Innovation Promotion Association CAS ; NIH ; NIH
WOS IDWOS:000445972400046
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/166991
Collection中国科学院大连化学物理研究所
Corresponding AuthorFang, Ning; Wang, Fangjun; El-Sayed, Mostafa A.
Affiliation1.Sch Chem & Biochem, Georgia Inst Technol, Laser Dynam Lab, Atlanta, GA 30332 USA
2.Georgia State Univ, Dept Chem, POB 3965, Atlanta, GA 30302 USA
3.Chinese Acad Sci, Natl Chromatog R&A Ctr, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China
4.Brigham & Womens Hosp, Dept Med Pulm & Crit Care Med, Boston, MA 02115 USA
5.Harvard Med Sch, Boston, MA 02115 USA
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wu, Yue,Ali, Moustafa R. K.,Dong, Bin,et al. Gold Nanorod Photothermal Therapy Alters Cell Junctions and Actin Network in Inhibiting Cancer Cell Collective Migration[J]. ACS NANO,2018,12(9):9279-9290.
APA Wu, Yue.,Ali, Moustafa R. K..,Dong, Bin.,Han, Tiegang.,Chen, Kuangcai.,...&El-Sayed, Mostafa A..(2018).Gold Nanorod Photothermal Therapy Alters Cell Junctions and Actin Network in Inhibiting Cancer Cell Collective Migration.ACS NANO,12(9),9279-9290.
MLA Wu, Yue,et al."Gold Nanorod Photothermal Therapy Alters Cell Junctions and Actin Network in Inhibiting Cancer Cell Collective Migration".ACS NANO 12.9(2018):9279-9290.
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