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Online Monitoring of Intraoperative Exhaled Propofol by Acetone-Assisted Negative Photoionization Ion Mobility Spectrometry Coupled with Time-Resolved Purge Introduction
Jiang, Dandan1,2; Li, Enyou3; Zhou, Qinghua1,2; Wang, Xin1; Li, Hanwei4; Ju, Bangyu1; Guo, Lei3; Liu, Desheng3; Li, Haiyang1
Source PublicationANALYTICAL CHEMISTRY
2018-04-17
ISSN0003-2700
DOI10.1021/acs.analchem.8b00171
Volume90Issue:8Pages:5280-5289
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordTOTAL INTRAVENOUS ANESTHESIA ; HUMAN BREATH ; AIR ; FEASIBILITY ; PLASMA ; DOPANT ; SEVOFLURANE ; EXPLOSIVES ; ARTERIAL ; SURGERY
AbstractOnline monitoring of exhaled propofol concentration is important for anesthetists to provide adequate anesthesia as propofol concentrations in plasma and breath are correlated reasonably well. Exhaled propofol could be detected by Ni-63 ion mobility spectrometry in negative ion mode; however, the radioactivity of Ni-63 source restricts its clinical application due to safety, environmental, and regulatory concerns. An acetone-assisted negative photoionization ion mobility spectrometer (AANP-IMS) using a side-mounted vacuum ultraviolet (VUV) lamp in the unidirectional (UD) flow mode was developed for sensitive measurement of exhaled propofol by producing a high percentage of O-2(-)(H2O)(n). An adsorption sampling and time-resolved purge introduction system was developed to eliminate the interference of residual inhaled anesthetic sevoflurane based on their different adsorptions between propofol and sevoflurane on the inwall of the fluorinated ethylene propylene (FEP) sample loop. The effects of the inner diameter and the length of the sample loop on the signal intensity of propofol and the time-resolution between propofol and sevoflurane were theoretically and experimentally investigated. A sample loop with 3 mm i.d. and 150 cm length allowed sensitive measurement of exhaled propofol with a response time of 4 s, a linear response range for propofol was achieved to be 0.2 to 14 ppbv with a limit of detection (LOD) of 60 pptv, and the quantification of propofol was not influenced by the change of the sevoflurane concentration. Finally, the performance of monitoring exhaled propofol during surgery was demonstrated on a patient undergoing laparoscopic distal pancreatectomy combined with cholecystectomy.
Language英语
WOS IDWOS:000430512200048
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/167107
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi, Haiyang
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Harbin Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
4.Jilin Univ, Coll Instrumentat & Elect Engn, Changchun 130026, Jilin, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Dandan,Li, Enyou,Zhou, Qinghua,et al. Online Monitoring of Intraoperative Exhaled Propofol by Acetone-Assisted Negative Photoionization Ion Mobility Spectrometry Coupled with Time-Resolved Purge Introduction[J]. ANALYTICAL CHEMISTRY,2018,90(8):5280-5289.
APA Jiang, Dandan.,Li, Enyou.,Zhou, Qinghua.,Wang, Xin.,Li, Hanwei.,...&Li, Haiyang.(2018).Online Monitoring of Intraoperative Exhaled Propofol by Acetone-Assisted Negative Photoionization Ion Mobility Spectrometry Coupled with Time-Resolved Purge Introduction.ANALYTICAL CHEMISTRY,90(8),5280-5289.
MLA Jiang, Dandan,et al."Online Monitoring of Intraoperative Exhaled Propofol by Acetone-Assisted Negative Photoionization Ion Mobility Spectrometry Coupled with Time-Resolved Purge Introduction".ANALYTICAL CHEMISTRY 90.8(2018):5280-5289.
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