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Acute exposure to crotonaldehyde induces dysfunction of immune system in male Wistar rats
Wang, Limeng1,2; Yang, Zhihua4; Xu, Long4; Pan, Xiujie4; Liu, Xingyu5; Zhao, Junwei3; Li, Xiang3; Zhu, Maoxiang4; Xie, Jianping3
KeywordCrotonaldehyde Male Wistar Rats Immune System
Source PublicationJOURNAL OF TOXICOLOGICAL SCIENCES
2018
ISSN0388-1350
Volume43Issue:1-3Pages:33-44
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectToxicology
WOS Research AreaToxicology
WOS KeywordCIGARETTE-SMOKE ; ALPHA,BETA-UNSATURATED ALDEHYDES ; ALVEOLAR MACROPHAGES ; BUTADIENE MONOXIDE ; LIVER MICROSOMES ; 1,3-BUTADIENE ; MICE ; INFLAMMATION ; ACROLEIN ; CELLS
AbstractCrotonaldehyde is a ubiquitous air pollutant in the environment. It is reported to be harmful to the biosystems in vivo and in vitro. The exposure to crotonaldehyde irritates the mucous membranes and induces edema, hyperemia, cell necrosis, inflammation, and acute respiratory distress syndrome in the lungs. However, the effects of crotonaldehyde on the immune system have not been reported. In the present study, 6-8 weeks old male Wistar rats were exposed to crotonaldehyde by intratracheal instillation at doses of 4, 8, and 16 mu L/kg body weight (b.w.). The general damage in the animals was investigated; the cell counting and the biochemical analysis in the peripheral blood were tested. Furthermore, we investigated the functions of alveolar macrophages (AMs), the alterations of the T-lymphocyte subsets, and the cell composition in the bronchoalveolar lavage fluid (BALF). We found that the activities of the animals were changed after exposure to crotonaldehyde, the cellular ratios and the biochemical components in the peripheral blood were altered, the ratio of mononuclear phagocytes decreased, and the ratios of lymphocytes and granulocytes elevated significantly in BALF. Meanwhile, crotonaldehyde altered the ratio of the T-lymphocyte subsets, and the phagocytic rates and indices of AMs increased obviously. In conclusion, crotonaldehyde induces dysfunction of immune system in male Wistar rats.
Language英语
WOS IDWOS:000430646100005
PublisherJAPANESE SOC TOXICOLOGICAL SCIENCES
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/167121
Collection中国科学院大连化学物理研究所
Corresponding AuthorXie, Jianping
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
3.Zhengzhou Tobacco Res Inst CNTC, Key Lab Tobacco Chem, 2 Fengyang Rd, Zhengzhou 450001, Henan, Peoples R China
4.Beijing Inst Radiat Med, Dept Radiat Toxicol & Oncol, 27 Taiping Rd, Beijing 100850, Peoples R China
5.Shanghai Tobacco Grp Corp CNTC, 99 Wansheng South St, Beijing 101121, Peoples R China
Recommended Citation
GB/T 7714
Wang, Limeng,Yang, Zhihua,Xu, Long,et al. Acute exposure to crotonaldehyde induces dysfunction of immune system in male Wistar rats[J]. JOURNAL OF TOXICOLOGICAL SCIENCES,2018,43(1-3):33-44.
APA Wang, Limeng.,Yang, Zhihua.,Xu, Long.,Pan, Xiujie.,Liu, Xingyu.,...&Xie, Jianping.(2018).Acute exposure to crotonaldehyde induces dysfunction of immune system in male Wistar rats.JOURNAL OF TOXICOLOGICAL SCIENCES,43(1-3),33-44.
MLA Wang, Limeng,et al."Acute exposure to crotonaldehyde induces dysfunction of immune system in male Wistar rats".JOURNAL OF TOXICOLOGICAL SCIENCES 43.1-3(2018):33-44.
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