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Direct Detection of Small & IT;n & IT;-Alkanes at Sub-ppbv Level by Photoelectron-Induced O-2(+) Cation Chemical Ionization Mass Spectrometry at kPa Pressure
Wang, Yan1,2; Hua, Lei1; Li, Qingyun3; Jiang, Jichun1; Hou, Keyong1; Wu, Chenxin1,2; Li, Haiyang1
Source PublicationANALYTICAL CHEMISTRY
2018-04-17
ISSN0003-2700
DOI10.1021/acs.analchem.8b00595
Volume90Issue:8Pages:5398-5404
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordSINGLE-PHOTON IONIZATION ; ATOMIC GOLD CATIONS ; ION FLOW TUBE ; OXIDATIVE STRESS ; BREATH ANALYSIS ; ATMOSPHERIC-PRESSURE ; LIPID-PEROXIDATION ; CROSS-SECTIONS ; EXHALED BREATH ; LINEAR ALKANES
AbstractDirect mass spectrometric measurements of saturated hydrocarbons, especially small n-alkanes, remains a great challenge because of low basicity and lack of ionizable functional groups. In this work, a novel high-pressure photoelectron-induced O-2(+) cation chemical ionization source (HPPI-OCI) at kPa based on a 10.6 eV krypton lamp was developed for a time-of-flight mass spectrometer (TOFMS). High-intensity O-2(+) reactant ions were generated by photo-electron ionization of air molecules in the double electric field ionization region. The quasi-molecular ions, [M-H](+), of C3-C6 n-alkanes, gradually dominated in the mass spectra when the ion source pressure was elevated from 88 to 1080 Pa, with more than 3 orders of magnitude improvement in signal intensity. As a result, the achieved limits of detection were lowered to 0.14, 0.11, 0.07, and 0.1 ppbv for propane, n-butane, n-pentane, and n-hexane, respectively. The performance of the HPPI-OCI TOFMS was first demonstrated by analysis of exhaled small n-alkanes from healthy smokers and nonsmokers. Then the concentration variations of exhaled small n-alkanes of four healthy volunteers were analyzed after alcohol consumption to explore the alcohol-hepatoxicity-related oxidative stress. In summary, this work provides new insights for controlling the O-2(+)-participating chemical ionization by adjusting the ion source pressure and develops a novel direct mass spectrometric method for sensitive measurements of mall n-alkanes.
Language英语
WOS IDWOS:000430512200063
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/167213
Collection中国科学院大连化学物理研究所
Corresponding AuthorHua, Lei; Li, Haiyang
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China
2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
3.Jilin Univ, Coll Instrumentat & Elect Engn, Changchun 130061, Jilin, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yan,Hua, Lei,Li, Qingyun,et al. Direct Detection of Small & IT;n & IT;-Alkanes at Sub-ppbv Level by Photoelectron-Induced O-2(+) Cation Chemical Ionization Mass Spectrometry at kPa Pressure[J]. ANALYTICAL CHEMISTRY,2018,90(8):5398-5404.
APA Wang, Yan.,Hua, Lei.,Li, Qingyun.,Jiang, Jichun.,Hou, Keyong.,...&Li, Haiyang.(2018).Direct Detection of Small & IT;n & IT;-Alkanes at Sub-ppbv Level by Photoelectron-Induced O-2(+) Cation Chemical Ionization Mass Spectrometry at kPa Pressure.ANALYTICAL CHEMISTRY,90(8),5398-5404.
MLA Wang, Yan,et al."Direct Detection of Small & IT;n & IT;-Alkanes at Sub-ppbv Level by Photoelectron-Induced O-2(+) Cation Chemical Ionization Mass Spectrometry at kPa Pressure".ANALYTICAL CHEMISTRY 90.8(2018):5398-5404.
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