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Multifunctionalized mesoporous silica as an efficient reversed-phase/anion exchange mixed-mode sorbent for solid-phase extraction of four acidic nonsteroidal anti-inflammatory drugs in environmental water samples
Li, Yun1; Huang, Chaonan1; Yang, Jiajia2; Peng, Junyu1; Jin, Jing1; Ma, Huilian1; Chen, Jiping1
KeywordMultifunctionalized Mesoporous Silica Mixed-mode Anion-exchanger Solid Phase Extraction Acidic Nsaids Environmental Water Samples
Source PublicationJOURNAL OF CHROMATOGRAPHY A
2017-12-08
ISSN0021-9673
DOI10.1016/j.chroma.2017.10.051
Volume1527Pages:10-17
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; TANDEM MASS-SPECTROMETRY ; CROSS-LINKED POLYSTYRENE ; WASTE-WATER ; OXIDE NANOCOMPOSITE ; STATIONARY PHASES ; MICROEXTRACTION ; RETENTION ; RESIDUE ; POLAR
AbstractA mesoporous silica Santa Barbara.Amorphous-15 (SBA-15) has been first functionalized with 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethoxysilane (a silane with three amines) and then reacted with an excess of phenyl glycidyl ether to generate a mixed-mode anion-exchanger containing both anion-exchange (three amines) and reversed-phase (multiple ether-linked phenyls) functionalities in a single branched ligand. The resulting material has been characterized by scanning electron microscopy, transmission electron microscopy, nitrogen adsorption-desorption measurements, Fourier-transform infrared spectroscopy, and elemental analysis. The results obtained indicated a BET specific surface area (S-BET) of 362.5 m(2) g(-1), a pore volume of 0.70 cm(3) g(-1) with a narrow pore size distribution centered at 6.6 nm, and carbon and nitrogen contents of 28.30% and 2.84%, respectively. The dimensions of these particles (similar to 5 mu m diameter, similar to 60 mu m length), their large surface areas, their high-density functionalities and anion-exchange mixed-mode characteristics make them very attractive for highly effective solid phase extraction (SPE) of acidic nonsteroidal anti-inflammatory drugs (NSAIDs). The important parameters on extraction efficiency including sample pH, breakthrough volume, type and volume of eluent were optimized. A simple and sensitive analytical method based on mixed-mode SPE coupled to high-performance liquid chromatography with ultraviolet detection (HPLC-UV) was developed and successfully applied to the analysis of four NSAIDs (ketoprofen, naproxen, diclofenac, and ibuprofen) in spiked real water samples with satisfactory recoveries (80.6-110.9%) and repeatability (relative standard deviation <11.3%, n = 3). The limit of detections of four NSAIDs were 0.006-0.070 mu g L-1 for tap water, and 0.014-0.16 mu g L-1 for river water and wastewater, with the enrichment factors of 806-1109-fold. (c) 2017 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000416395600002
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/168337
Collection中国科学院大连化学物理研究所
Corresponding AuthorChen, Jiping
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Hebei Univ Engn, Coll Mat Sci & Engn, 199 South Guangming St, Handan 056038, Peoples R China
Recommended Citation
GB/T 7714
Li, Yun,Huang, Chaonan,Yang, Jiajia,et al. Multifunctionalized mesoporous silica as an efficient reversed-phase/anion exchange mixed-mode sorbent for solid-phase extraction of four acidic nonsteroidal anti-inflammatory drugs in environmental water samples[J]. JOURNAL OF CHROMATOGRAPHY A,2017,1527:10-17.
APA Li, Yun.,Huang, Chaonan.,Yang, Jiajia.,Peng, Junyu.,Jin, Jing.,...&Chen, Jiping.(2017).Multifunctionalized mesoporous silica as an efficient reversed-phase/anion exchange mixed-mode sorbent for solid-phase extraction of four acidic nonsteroidal anti-inflammatory drugs in environmental water samples.JOURNAL OF CHROMATOGRAPHY A,1527,10-17.
MLA Li, Yun,et al."Multifunctionalized mesoporous silica as an efficient reversed-phase/anion exchange mixed-mode sorbent for solid-phase extraction of four acidic nonsteroidal anti-inflammatory drugs in environmental water samples".JOURNAL OF CHROMATOGRAPHY A 1527(2017):10-17.
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