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Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma
Tang, Ling1,2,3; Zeng, Jun2,4; Geng, Pengyu1; Fang, Chengnan2; Wang, Yang1,3; Sun, Mingju1; Wang, Changsong5,6; Wang, Jiao3; Yin, Peiyuan2; Hu, Chunxiu2; Guo, Lei5; Yu, Jane7; Gao, Peng1; Li, Enyou5; Zhuang, Zhengping8; Xu, Guowang2; Liu, Yang1
Source PublicationCLINICAL CANCER RESEARCH
2018-01-15
ISSN1078-0432
DOI10.1158/1078-0432.CCR-17-1707
Volume24Issue:2Pages:474-485
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectOncology
WOS Research AreaOncology
WOS KeywordCANCER-CELLS ; C-MYC ; SORAFENIB RESISTANCE ; GLUTAMINE-METABOLISM ; TUMOR-SUPPRESSOR ; INHIBITION ; PROLIDASE ; GROWTH ; PROTEIN ; LIVER
AbstractPurpose: Metabolic reprogramming is frequently identified in hepatocellular carcinoma (HCC), which is the most common type of liver malignancy. The reprogrammed cellular metabolisms promote tumor cell survival, proliferation, angiogenesis, and metastasis. However, the mechanisms of this process remain unclear in HCC.
Language英语
WOS IDWOS:000422883900022
PublisherAMER ASSOC CANCER RESEARCH
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/168549
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu, Guowang; Liu, Yang
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Sci Res Ctr Translat Med, Dalian, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China
3.Dalian Univ, Sch Life Sci, Dalian, Peoples R China
4.Univ Chinese Acad Sci, Dalian, Peoples R China
5.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin, Heilongjiang, Peoples R China
6.Harbin Med Univ, Affiliated Hosp 3, Dept Crit Care Med, Harbin, Heilongjiang, Peoples R China
7.Univ Cincinnati, Dept Med, Div Pulm Crit Care & Sleep Med, Cincinnati, OH USA
8.NINDS, Surg Neurol Branch, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
Recommended Citation
GB/T 7714
Tang, Ling,Zeng, Jun,Geng, Pengyu,et al. Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma[J]. CLINICAL CANCER RESEARCH,2018,24(2):474-485.
APA Tang, Ling.,Zeng, Jun.,Geng, Pengyu.,Fang, Chengnan.,Wang, Yang.,...&Liu, Yang.(2018).Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma.CLINICAL CANCER RESEARCH,24(2),474-485.
MLA Tang, Ling,et al."Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma".CLINICAL CANCER RESEARCH 24.2(2018):474-485.
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