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Chamaejasmine B Induces the Anergy of Vascular Endothelial Cells to VEGFA Pro-angiogenic Signal by Autophagic Regulation of VEGFR2 in Breast Cancer
Li, Qi1; Kan, Xiaoxi1; Yin, Jie1,2; Sun, Lidong1; Wang, Yajie1; Li, Yujie1; Yang, Qing1; Xiao, Hongbin3; Chen, Ying1; Weng, Xiaogang1; Cai, Weiyan1; Zhu, Xiaoxin1
KeywordChamaejasmine b Anti-angiogenesis Chemotherapy Breast Cancer Autophagy Vegfr2
Source PublicationFRONTIERS IN PHARMACOLOGY
2018-01-22
ISSN1663-9812
DOI10.3389/fphar.2017.00963
Volume8
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectPharmacology & Pharmacy
WOS Research AreaPharmacology & Pharmacy
WOS KeywordTUMOR ANGIOGENESIS ; METASTASIS ; THERAPY ; MECHANISMS ; INHIBITORS ; SUNITINIB ; COLONIZATION ; PERSPECTIVE ; CARCINOMA ; APOPTOSIS
AbstractThe neovascularization functions essentially for malignant upgrading and predicts poor prognosis in multiple cancers, which make it the highly effective strategy for clinical treatment. Unfortunately, the known anti-angiogenic therapies show low effectiveness against breast cancer. Recently, rebalancing the pro-angiogenic property in microenvironment shows great advantages and attracts increasing attention for breast cancer treatment. Herein, we for the first time reported that Chamaejasmine B (ICJ), extracted from Stellera chamaejasme L., possessed potent anti-angiogenic effect in breast cancer. By Transwell, tube formation and aortic-ring assays, ICJ efficiently suppressed the neovascularization potential in tumor-HUVEC co-culture model. In Matrigel plug assay, the efficacy of ICJ was further identified in vivo. Mechanistically, with little influence on HUVEC apoptosis, ICJ obviously induced autophagy as proved by the elevated LC3I/II ratio, dotted distribution of LC3 and upregulated Beclin-1. Moreover, by associating with LC3 and in turn, inhibiting the level of VEGFR2, the anti-angiogenesis efficacy was closely dependent on the initiation of autophagy. Above results proved that, by attenuating the pro-angiogenic communication through VEGFR2, ICJ is a novel angiogenic inhibitor and will be a promising supplement for anti-angiogenic chemotherapy for breast cancer.
Language英语
WOS IDWOS:000422961500001
PublisherFRONTIERS MEDIA SA
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/168555
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhu, Xiaoxin
Affiliation1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China
2.Capital Med Univ, Sch Tradit Chinese Med, Beijing, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Li, Qi,Kan, Xiaoxi,Yin, Jie,et al. Chamaejasmine B Induces the Anergy of Vascular Endothelial Cells to VEGFA Pro-angiogenic Signal by Autophagic Regulation of VEGFR2 in Breast Cancer[J]. FRONTIERS IN PHARMACOLOGY,2018,8.
APA Li, Qi.,Kan, Xiaoxi.,Yin, Jie.,Sun, Lidong.,Wang, Yajie.,...&Zhu, Xiaoxin.(2018).Chamaejasmine B Induces the Anergy of Vascular Endothelial Cells to VEGFA Pro-angiogenic Signal by Autophagic Regulation of VEGFR2 in Breast Cancer.FRONTIERS IN PHARMACOLOGY,8.
MLA Li, Qi,et al."Chamaejasmine B Induces the Anergy of Vascular Endothelial Cells to VEGFA Pro-angiogenic Signal by Autophagic Regulation of VEGFR2 in Breast Cancer".FRONTIERS IN PHARMACOLOGY 8(2018).
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