DICP OpenIR
Identification of SPOP related metabolic pathways in prostate cancer
Yan, Min1,2,3; Qi, Huan1; Li, Jia2,3; Ye, Guozhu2,3; Shao, Yaping2,3; Li, Tongming1; Liu, Jing1; Piao, Hai-Long1,3; Xu, Guowang2,3
KeywordSpop Metabolism
Source PublicationONCOTARGET
2017-11-28
ISSN1949-2553
DOI10.18632/oncotarget.21460
Volume8Issue:61Pages:103032-103046
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectOncology ; Cell Biology
WOS Research AreaOncology ; Cell Biology
WOS KeywordANDROGEN RECEPTOR ; POTENTIAL BIOMARKER ; TCA CYCLE ; RNA-SEQ ; PROGRESSION ; TRANSCRIPTOMICS ; DEGRADATION ; INTEGRATION ; MUTATIONS ; UBIQUITINATION
AbstractSpeckle-type POZ protein (SPOP), as a cullin-based E3 ubiquitin ligase, has been identified as one of the most frequently mutated genes in prostate cancer (PCa). However, whether SPOP mutations contribute to metabolic reprogramming in PCa remains unknown. Here, integrated studies of transcriptomics and metabolomics as well as lipidomics were performed in matched PCa tumor (PCT) and adjacent non-tumor (ANT) tissues, followed by correlation analysis of SPOP mutations with altered metabolic pathways in SPOP-mutated PCa patients. Interestingly, transcriptomics profiling showed that all SPOP mutations (with 16.7% frequency, 11/66) occurred at the conserved residues in the substrate binding domain of meprin and TRAF homology (MATH). The results of integrated analysis indicated that three metabolic pathways, including tricarboxylic acid (TCA) cycle, fatty acid metabolism and glycerophospholipid metabolism, exhibited obvious upregulation in SPOP-mutated PCT tissues. Furthermore, both correlation analyses based on integrated data and cBioportal revealed that FH, ELOVL2 and ACADL genes might be involved in SPOP-mutation-related upregulation of these metabolic pathways. Taken together, our study provided new insights in understanding the relationship between metabolic pathways and SPOP mutations in PCa.
Language英语
WOS IDWOS:000419562500025
PublisherIMPACT JOURNALS LLC
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/168655
Collection中国科学院大连化学物理研究所
Corresponding AuthorPiao, Hai-Long; Xu, Guowang
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Sci Res Ctr Translat Med, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yan, Min,Qi, Huan,Li, Jia,et al. Identification of SPOP related metabolic pathways in prostate cancer[J]. ONCOTARGET,2017,8(61):103032-103046.
APA Yan, Min.,Qi, Huan.,Li, Jia.,Ye, Guozhu.,Shao, Yaping.,...&Xu, Guowang.(2017).Identification of SPOP related metabolic pathways in prostate cancer.ONCOTARGET,8(61),103032-103046.
MLA Yan, Min,et al."Identification of SPOP related metabolic pathways in prostate cancer".ONCOTARGET 8.61(2017):103032-103046.
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