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A metabolomics strategy to assess the combined toxicity of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs)
Wang, Feidi1,2; Zhang, Haijun1; Geng, Ningbo1; Ren, Xiaoqian1,2; Zhang, Baoqin1; Gong, Yufeng1; Chen, Jiping1
KeywordCombined Toxicity Metabolomics Polycyclic Aromatic Hydrocarbons Short-chain Chlorinated Paraffins
Source PublicationENVIRONMENTAL POLLUTION
2018-03-01
ISSN0269-7491
DOI10.1016/j.envpol.2017.11.073
Volume234Pages:572-580
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectEnvironmental Sciences
WOS Research AreaEnvironmental Sciences & Ecology
WOS KeywordENVIRONMENTAL RISK-ASSESSMENT ; HEPG2 CELLS ; N-ALKANES ; EXPOSURE ; MECHANISM ; BLOOD ; LIVER ; MILK ; PERSPECTIVE ; METABOLISM
AbstractThe combined toxicity of mixed chemicals is usually evaluated according to several specific endpoints, and other potentially toxic effects are disregarded. In this study, we provided a metabolomics strategy to achieve a comprehensive understanding of toxicological interactions between mixed chemicals on metabolism. The metabolic changes were quantified by a pseudotargeted analysis, and the types of combined effects were quantitatively discriminated according to the calculation of metabolic effect level index (MELI). The metabolomics strategy was used to assess the combined effects of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs) on the metabolism of human hepatoma HepG2 cells. Our data suggested that exposure to a combination of PAHs and SCCPs at human internal exposure levels could result in an additive effect on the overall metabolism, whereas diverse joint effects were observed on various metabolic pathways. The combined exposure could induce a synergistic up-regulation of phospholipid metabolism, an additive up -regulation of fatty acid metabolism, an additive down-regulation of tricarboxylic acid cycle and glycolysis, and an antagonistic effect on purine metabolism. SCCPs in the mixture acted as the primary driver for the acceleration of phospholipid and fatty acid metabolism. Lipid metabolism disorder caused by exposure to a combination of PAHs and SCCPs should be an important concern for human health. (C) 2017 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000426225100060
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/168679
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhang, Haijun
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wang, Feidi,Zhang, Haijun,Geng, Ningbo,et al. A metabolomics strategy to assess the combined toxicity of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs)[J]. ENVIRONMENTAL POLLUTION,2018,234:572-580.
APA Wang, Feidi.,Zhang, Haijun.,Geng, Ningbo.,Ren, Xiaoqian.,Zhang, Baoqin.,...&Chen, Jiping.(2018).A metabolomics strategy to assess the combined toxicity of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs).ENVIRONMENTAL POLLUTION,234,572-580.
MLA Wang, Feidi,et al."A metabolomics strategy to assess the combined toxicity of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs)".ENVIRONMENTAL POLLUTION 234(2018):572-580.
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