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Green synthesis of new pyrrolidine-fused spirooxindoles via three-component domino reaction in EtOH/H2O
Wang, Yong-Chao1; Wang, Jun-Liang3; Burgess, Kevin S.4; Zhang, Jiang-Wei5; Zheng, Qiu-Mei1; Pu, Ya-Dan1; Yan, Li-Jun1; Chen, Xue-Bing2
Source PublicationRSC ADVANCES
2018
ISSN2046-2069
DOI10.1039/c7ra13207g
Volume8Issue:11Pages:5702-5713
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordSTEREOSELECTIVE 1,3-DIPOLAR CYCLOADDITION ; POT MULTICOMPONENT SYNTHESIS ; STRUCTURE-BASED DESIGN ; MAMMALIAN-CELL CYCLE ; DIASTEREOSELECTIVE SYNTHESIS ; ANTIMYCOBACTERIAL ACTIVITY ; ASPERGILLUS-FUMIGATUS ; EFFICIENT SYNTHESIS ; MOLECULAR DOCKING ; FACILE SYNTHESIS
AbstractAn efficient, green and sustainable approach for the synthesis of novel polycyclic pyrrolidine-fused spirooxindole compounds was developed. The synthesis included a one-pot, three-component, domino reaction of (E)-3-(2-nitrovinyl)-indoles, isatins and chiral polycyclic a-amino acids under catalyst-free conditions at room temperature in EtOH-H2O. The salient features of this methodology are eco-friendliness, high yields and the ease of obtaining target compounds without the involvement of toxic solvents and column chromatography. These novel polycyclic pyrrolidine-fused spirooxindoles provide a collection of structurally diverse compounds that show promise for future bioassays and medical treatments.
Language英语
WOS IDWOS:000424465500008
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/168773
Collection中国科学院大连化学物理研究所
Corresponding AuthorWang, Yong-Chao; Yan, Li-Jun; Chen, Xue-Bing
Affiliation1.Yunnan Normal Univ, Sch Vocat & Tech Educ, Kunming 650092, Yunnan, Peoples R China
2.Honghe Univ, Sch Sci, Key Lab Nat Pharmaceut & Chem Biol Yunnan Prov, Mengzi 661199, Yunnan, Peoples R China
3.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China
4.Columbus State Univ, Univ Syst Georgia, Coll Letters & Sci, Dept Biol, Columbus, GA USA
5.Chinese Acad Sci, Gold Catalysis Res Ctr, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yong-Chao,Wang, Jun-Liang,Burgess, Kevin S.,et al. Green synthesis of new pyrrolidine-fused spirooxindoles via three-component domino reaction in EtOH/H2O[J]. RSC ADVANCES,2018,8(11):5702-5713.
APA Wang, Yong-Chao.,Wang, Jun-Liang.,Burgess, Kevin S..,Zhang, Jiang-Wei.,Zheng, Qiu-Mei.,...&Chen, Xue-Bing.(2018).Green synthesis of new pyrrolidine-fused spirooxindoles via three-component domino reaction in EtOH/H2O.RSC ADVANCES,8(11),5702-5713.
MLA Wang, Yong-Chao,et al."Green synthesis of new pyrrolidine-fused spirooxindoles via three-component domino reaction in EtOH/H2O".RSC ADVANCES 8.11(2018):5702-5713.
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