DICP OpenIR
Developmental and metabolic responses of zebrafish (Danio rerio) embryos and larvae to short-chain chlorinated paraffins (SCCPs) exposure
Ren, Xiaodian1,2; Zhang, Haijun1; Geng, Ningbo1; Xing, Liguo3; Zhao, Yu3; Wang, Feidi1,2; Chen, Jiping1
KeywordShort-chain Chlorinated Paraffins Zebrafish Embryo/larvae Metabolomics Developmental Toxicity
Source PublicationSCIENCE OF THE TOTAL ENVIRONMENT
2018-05-01
ISSN0048-9697
DOI10.1016/j.scitotenv.2017.11.304
Volume622Pages:214-221
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectEnvironmental Sciences
WOS Research AreaEnvironmental Sciences & Ecology
WOS KeywordRETINAL GANGLION-CELLS ; N-ALKANES ; PURINE METABOLISM ; MASS-SPECTROMETRY ; TROPHIC TRANSFER ; BOHAI SEA ; BIOACCUMULATION ; INOSINE ; LYSOPHOSPHATIDYLCHOLINE ; DEREGULATION
AbstractShort-chain chlorinated paraffins (SCCPs) are highly toxic to aquatic organisms, but their toxicity is yet not well characterized. In this study, the developmental toxicity of SCCPs to zebrafish embryos/larvae was evaluated, and a metabolomics approach was adopted to explore the impact of SCCPs exposure on the metabolismin zebrafish embryos. Exposure to SCCPs at concentrations of 1-200 mu g/L did not produce an observable effect on the hatching rate andmorphological deformities of zebrafish embryos/ larvae. However, the survival rate of zebrafish larvae in SCCPs exposure groups decreased in a concentration-dependent manner. The 13-day 50% lethal concentration (LC50) value of SCCPs was calculated to be 34.4 mu g/L. Exposure to SCCPs induced a significant change of overall metabolism, even at environmentally relevant concentrations (1-5 mu g/L). The most relevant pathways affected by SCCPs exposure were glycerophospholipid metabolism, fatty acid metabolism and purine metabolism. Exposure to SCCPs at concentrations of 1-5 mu g/L had begun to accelerate the beta-oxidation of unsaturated fatty acids and very long chain fatty acids, and affect the transformation of guanine to xanthine in the pathway of purinemetabolism. Furthermore, when the exposure concentrations of SCCPs were increased to 50-200 mu g/L, the levels of phospholipids and amino acids were significantly raised; whereas the levels of fatty acids, carnitines and inosine were significantly decreased. In view of the significant effect on metabolism, the sub-chronic and chronic toxicity of SCCPs to fish should be concerned. (C) 2017 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000426349000024
PublisherELSEVIER SCIENCE BV
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/168841
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhang, Haijun; Chen, Jiping
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Shenyang Res Inst Chem Ind Ltd, Safety Evaluat Ctr, Shenyang 110021, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Ren, Xiaodian,Zhang, Haijun,Geng, Ningbo,et al. Developmental and metabolic responses of zebrafish (Danio rerio) embryos and larvae to short-chain chlorinated paraffins (SCCPs) exposure[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2018,622:214-221.
APA Ren, Xiaodian.,Zhang, Haijun.,Geng, Ningbo.,Xing, Liguo.,Zhao, Yu.,...&Chen, Jiping.(2018).Developmental and metabolic responses of zebrafish (Danio rerio) embryos and larvae to short-chain chlorinated paraffins (SCCPs) exposure.SCIENCE OF THE TOTAL ENVIRONMENT,622,214-221.
MLA Ren, Xiaodian,et al."Developmental and metabolic responses of zebrafish (Danio rerio) embryos and larvae to short-chain chlorinated paraffins (SCCPs) exposure".SCIENCE OF THE TOTAL ENVIRONMENT 622(2018):214-221.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ren, Xiaodian]'s Articles
[Zhang, Haijun]'s Articles
[Geng, Ningbo]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ren, Xiaodian]'s Articles
[Zhang, Haijun]'s Articles
[Geng, Ningbo]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ren, Xiaodian]'s Articles
[Zhang, Haijun]'s Articles
[Geng, Ningbo]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.