Ammonium hydroxide enhancing electrospray response and boosting sensitivity of bisphenol A and its analogs
Tan, Dongqin1,2; Jin, Jing1; Wang, Longxing1; Zhao, Xueqin; Guo, Cuicui1,2; Sun, Xiaoli3,4; Dhanjai1; Lu, Xianbo1; Chen, Jiping1
KeywordBisphenol Ammonium Hydroxide Electrospray Ionization Ionization Efficiency
Source PublicationTALANTA
Indexed BySCI
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
AbstractAs one of the most important analytical techniques for accurate quantification of bisphenol compounds, liquid chromatography coupled to online electrospray ionization (ESI) tandem mass spectrometry exhibits relative weak ESI response in negative mode, which greatly reduces their sensitivity and limits their detection at trace levels, especially in complex samples such as blood. Based on the facilitated deprotonation of bisphenol molecule under alkaline condition, post-column injection of ammonium hydroxide (NH3 center dot H2O) to mass spectrometer was explored to enhance the ionization efficiency of BPA and its eight analogs and improve their analytical sensitivity. Parameters effecting response intensity and stability were investigated, including mass concentration and flow rate of NH3 center dot H2O. Under the optimal conditions with the addition of 2% (w/w) of NH3 center dot H2O at 4 mu L min(-1), the instrument detection limits for bisphenol compounds were greatly lowered to 0.001-0.04 ng mL(-1), which were 2-28.6 times lower than the result obtained without injecting NH3 center dot H2O, except TBBPA (0.03 ng mL(-1) in either case). The relative standard deviations (RSDs) for instrument repeatability of BPA and its analogs at three different concentration levels were in a range of 1.2-20%. Furthermore, a decreased matrix effects (90-111%) for bisphenols (except TBBPA) analysis in serum extracts were found compared with the result obtained without NH3 center dot H2O injection (43-111%). The results demonstrated that the improved instrumental method coupled with suitable pretreatment techniques is more feasible to analyze bisphenol compounds in complex bio-samples.
WOS IDWOS:000428229200075
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorChen, Jiping
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangzhou 511436, Guangdong, Peoples R China
4.Lishui Univ, Dept Chem, Lishui 32300, Peoples R China
Recommended Citation
GB/T 7714
Tan, Dongqin,Jin, Jing,Wang, Longxing,et al. Ammonium hydroxide enhancing electrospray response and boosting sensitivity of bisphenol A and its analogs[J]. TALANTA,2018,182:590-594.
APA Tan, Dongqin.,Jin, Jing.,Wang, Longxing.,Zhao, Xueqin.,Guo, Cuicui.,...&Chen, Jiping.(2018).Ammonium hydroxide enhancing electrospray response and boosting sensitivity of bisphenol A and its analogs.TALANTA,182,590-594.
MLA Tan, Dongqin,et al."Ammonium hydroxide enhancing electrospray response and boosting sensitivity of bisphenol A and its analogs".TALANTA 182(2018):590-594.
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