DICP OpenIR
2D transition metal carbide MXene as a robust biosensing platform for enzyme immobilization and ultrasensitive detection of phenol
Wu, Lingxia1,3; Lu, Xianbo1; Dhanjai1; Wu, Zhong-Shuai2; Dong, Yanfeng2; Wang, Xiaohui4; Zheng, Shuanghao2,3; Chen, Jiping1
KeywordMxene Transition Metal Carbides Biosensor Tyrosinase Phenol
Source PublicationBIOSENSORS & BIOELECTRONICS
2018-06-01
ISSN0956-5663
DOI10.1016/j.bios.2018.02.021
Volume107Pages:69-75
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology
WOS Research AreaBiophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
WOS Keyword2-DIMENSIONAL TITANIUM CARBIDE ; WATER-SOLUBLE GRAPHENE ; TI3C2 MXENE ; FUNCTIONALIZED GRAPHENE ; DIRECT ELECTROCHEMISTRY ; AQUEOUS-MEDIA ; ION BATTERIES ; ADSORPTION ; INTERCALATION ; EXFOLIATION
AbstractMXene-Ti3C2, as a new class of two-dimensional (2D) transition metal carbides (or nitrides), has been synthesized by exfoliating pristine Ti3AlC2 phases with hydrofluoric acid. The SEM and XRD images show that the resultant MXene possesses a graphene-like 2D nanostructure. and the surface of MXene has been partially terminated with-OH, thus providing a favorable microenvironment for enzyme immobilization and retaining their bioactivity and stability. Considering the unique metallic conductivity, biocompatibility and good dispersion in aqueous phase, the as-prepared MXene was explored as a new matrix to immobilize tyrosinase (a model enzyme) for fabricating a mediator-free biosensor for ultrasensidve and rapid detection of phenol. The varying electrochemical measurements were used to investigate the electrochemical performance of MXene-based tyrosinase biosensors. The results revealed that the direct electron transfer between tyrosinase and electrode could be easily achieved via a surface-controlled electrochemical process. The fabricated MXene-based tyrosinase biosensors exhibited good analytical performance over a wide linear range from 0.05 to 15.5 mu mol L-1, with a low detection limit of 12 nmol L-1 and a sensitivity of 414.4 mA M-1. The proposed biosensing approach also demonstrated good repeatability, reproducibility, long-term stability and high recovery for phenol detection in real water samples. With those excellent performances, MXene with graphene-like structure is proved to be a robust and versatile electrochemical biosensing platform for enzyme-based biosensors and biocatalysis, and has wide potential applications in biomedical detection and environmental analysis.
Language英语
WOS IDWOS:000428006900010
PublisherELSEVIER ADVANCED TECHNOLOGY
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/169121
Collection中国科学院大连化学物理研究所
Corresponding AuthorLu, Xianbo
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, 457 Zhongshan Rd, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Wu, Lingxia,Lu, Xianbo,Dhanjai,et al. 2D transition metal carbide MXene as a robust biosensing platform for enzyme immobilization and ultrasensitive detection of phenol[J]. BIOSENSORS & BIOELECTRONICS,2018,107:69-75.
APA Wu, Lingxia.,Lu, Xianbo.,Dhanjai.,Wu, Zhong-Shuai.,Dong, Yanfeng.,...&Chen, Jiping.(2018).2D transition metal carbide MXene as a robust biosensing platform for enzyme immobilization and ultrasensitive detection of phenol.BIOSENSORS & BIOELECTRONICS,107,69-75.
MLA Wu, Lingxia,et al."2D transition metal carbide MXene as a robust biosensing platform for enzyme immobilization and ultrasensitive detection of phenol".BIOSENSORS & BIOELECTRONICS 107(2018):69-75.
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