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Serum Metabolomics Study of Gliclazide-Modified-Release-Treated Type 2 Diabetes Mellitus Patients Using a Gas Chromatography-Mass Spectrometry Method
Zhou, Yang1,4; Hu, Cheng2,3; Zhao, Xinjie1,4; Luo, Ping1,4; Lu, Jingyi2; Li, Qing2; Chen, Miao2; Yan, Dandan2; Lu, Xin1,4; Kong, Hongwei1,4; Jia, Weiping2; Xu, Guowang1,4
KeywordMetabolomics Gliclazide Modified Release Sulfonylureas Type 2 Diabetes Mellitus Gas Chromatography-mass Spectrometry Biomarker
Source PublicationJOURNAL OF PROTEOME RESEARCH
2018-04-01
ISSN1535-3893
DOI10.1021/acs.jproteome.7b00866
Volume17Issue:4Pages:1575-1585
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemical Research Methods
WOS Research AreaBiochemistry & Molecular Biology
WOS KeywordINSULIN-RESISTANCE ; HEPATOCELLULAR-CARCINOMA ; METABOLITE BIOMARKER ; GLUCOSE-HOMEOSTASIS ; SKELETAL-MUSCLE ; SULFONYLUREA ; EFFICACY ; TAURINE ; ALPHA ; BETA
AbstractSulfonylureas are one of the commonly used drugs in type 2 diabetes mellitus (T2DM) but with considerable incidence of monotherapy failure. However, the mechanism of patients' drug response is unclear, and suitability evaluation biomarkers are in urgent need for precision medicine. In this study, a pseudotargeted gas chromatography-mass spectrometry method was employed to investigate the serum metabolic profiling of 66 significant responders and 24 nonsignificant responders at baseline and 16 weeks after gliclazide modified-release (MR) monotherapy. Clinical improvements in blood glucose level and insulin sensitivity were closely associated with the alterations of TCA cycle, ketone body metabolism, lipid oxidation, branched-chain amino acid catabolism, and gut flora metabolism. The different baseline metabolic profiling observed in the two groups implied that patients with lower dyslipidemia level may be more suitable for sulfonylurea therapy. The biomarker panel consisting of HbA1C, 5,8,11,14,17-eicosapentaenoic acid, methyl 8,11,14-eicosatrienoate, and methyl hexadecanoate shows a very good prediction ability for the suitability of glidazide treatment, and it may be meaningful in personalized medicine of T2DM patients by sulfonylurea therapy.
Language英语
WOS IDWOS:000429886600021
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/169161
Collection中国科学院大连化学物理研究所
Corresponding AuthorLu, Xin; Jia, Weiping; Xu, Guowang
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Diabet Inst,Shanghai Clin Ctr Diabet, Dept Endocrinol & Metab,Shanghai Key Lab Diabet M, Shanghai 200233, Peoples R China
3.Southern Med Univ, Fengxian Cent Hosp Affiliated, Inst Metab Dis, 6600 Nanfeng Rd, Shanghai 201499, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Yang,Hu, Cheng,Zhao, Xinjie,et al. Serum Metabolomics Study of Gliclazide-Modified-Release-Treated Type 2 Diabetes Mellitus Patients Using a Gas Chromatography-Mass Spectrometry Method[J]. JOURNAL OF PROTEOME RESEARCH,2018,17(4):1575-1585.
APA Zhou, Yang.,Hu, Cheng.,Zhao, Xinjie.,Luo, Ping.,Lu, Jingyi.,...&Xu, Guowang.(2018).Serum Metabolomics Study of Gliclazide-Modified-Release-Treated Type 2 Diabetes Mellitus Patients Using a Gas Chromatography-Mass Spectrometry Method.JOURNAL OF PROTEOME RESEARCH,17(4),1575-1585.
MLA Zhou, Yang,et al."Serum Metabolomics Study of Gliclazide-Modified-Release-Treated Type 2 Diabetes Mellitus Patients Using a Gas Chromatography-Mass Spectrometry Method".JOURNAL OF PROTEOME RESEARCH 17.4(2018):1575-1585.
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