DICP OpenIR
Stereoselective Stabilization of Polymeric Vitamin E Conjugate Micelles
Gao, Min1,2; Deng, Jian1,2; Chu, Huiying3; Tang, Yu4; Wang, Zheng1,2,5; Zhao, Yanjun1,2,5; Li, Guohui3
Source PublicationBIOMACROMOLECULES
2017-12-01
ISSN1525-7797
DOI10.1021/acs.biomac.7b01409
Volume18Issue:12Pages:4349-4356
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS KeywordALPHA-HELICAL POLYPEPTIDES ; ANTICANCER DRUG-DELIVERY ; SIDE-CHAIN ; STABILITY ; ARCHITECTURE ; CHIRALITY ; CURCUMIN ; RELEASE ; ACID)
AbstractVitamin E (alpha-tocopherol; TPGS) micelle is a robust nanocarrier in delivering hydrophobic active pharmaceutical ingredients, but it is suffering from poor stability that is essential in terms of pharmaceutical and biomedical applications. Taking advantage of the chirality of vitamin E, this work reports the stereoselective stabilization of polymer-vitamin E conjugate micelles. Vitamin E was covalently linked to multivalent methoxy poly(ethylene glycol)-co-poly(glutamic acid), generating amphiphilic conjugates that could self-assemble into micelles. Eight types of micelles were produced via tailored combination of polymer backbone and side chain with different chirality. The particle size and critical micelle concentration analysis demonstrated a correlation between conjugate chirality and micelle stability. The most stable micelles were obtained when poly(glutamic acid) and vitamin E both are dextrorotatory, because of the high degree of alpha-helix revealed by both circular dichroism spectroscopy and molecular dynamics simulation. This phenomenon was further verified by the fluorescence resonance energy transfer (FRET) analysis in HepG2 cells. The current work not only provides a method to enhance the stability of vitamin E micelles, but also adds an additional facile tool in regulating the stability of polymer conjugate micelles without changing the conjugate composition.
Language英语
WOS IDWOS:000418109200049
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/169205
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhao, Yanjun; Li, Guohui
Affiliation1.Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China
2.Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Lab Mol Modeling & Design, 457 Zhongshan Rd, Dalian 116023, Peoples R China
4.Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, 5 Yunshan Rd, Qingdao 266003, Peoples R China
5.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Recommended Citation
GB/T 7714
Gao, Min,Deng, Jian,Chu, Huiying,et al. Stereoselective Stabilization of Polymeric Vitamin E Conjugate Micelles[J]. BIOMACROMOLECULES,2017,18(12):4349-4356.
APA Gao, Min.,Deng, Jian.,Chu, Huiying.,Tang, Yu.,Wang, Zheng.,...&Li, Guohui.(2017).Stereoselective Stabilization of Polymeric Vitamin E Conjugate Micelles.BIOMACROMOLECULES,18(12),4349-4356.
MLA Gao, Min,et al."Stereoselective Stabilization of Polymeric Vitamin E Conjugate Micelles".BIOMACROMOLECULES 18.12(2017):4349-4356.
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