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Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment
Gu, Yanyun1; Wang, Xiaokai2,3; Li, Junhua2,4; Zhang, Yifei1; Zhong, Huanzi2,5; Liu, Ruixin1; Zhang, Dongya2; Feng, Qiang2; Xie, Xiaoyan1; Hong, Jie1; Ren, Huahui2,4,6; Liu, Wei7; Ma, Jing7; Su, Qing8; Zhang, Hongmei8; Yang, Jialin9; Wang, Xiaoling10; Zhao, Xinjie10; Gu, Weiqiong1; Bi, Yufang1; Peng, Yongde11; Xu, Xiaoqiang2,3; Xia, Huihua2,4; Li, Fang2,4,6; Xu, Xun2; Yang, Huanming2,12; Xu, Guowang10; Madsen, Lise2,3,13; Kristiansen, Karsten2,5; Ning, Guang1; Wang, Weiqing1
Source PublicationNATURE COMMUNICATIONS
2017-11-27
ISSN2041-1723
DOI10.1038/s41467-017-01682-2
Volume8
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordFARNESOID-X-RECEPTOR ; INSULIN-RESISTANCE ; BARIATRIC SURGERY ; RANDOMIZED-TRIAL ; SERUM METABOLOME ; METFORMIN ; GLUCOSE ; ENTEROTYPES ; METAGENOME ; ACARBOSE
AbstractAntidiabetic medication may modulate the gut microbiota and thereby alter plasma and faecal bile acid (BA) composition, which may improve metabolic health. Here we show that treatment with Acarbose, but not Glipizide, increases the ratio between primary BAs and secondary BAs and plasma levels of unconjugated BAs in treatment-naive type 2 diabetes (T2D) patients, which may beneficially affect metabolism. Acarbose increases the relative abundances of Lactobacillus and Bifidobacterium in the gut microbiota and depletes Bacteroides, thereby changing the relative abundance of microbial genes involved in BA metabolism. Treatment outcomes of Acarbose are dependent on gut microbiota compositions prior to treatment. Compared to patients with a gut microbiota dominated by Prevotella, those with a high abundance of Bacteroides exhibit more changes in plasma BAs and greater improvement in metabolic parameters after Acarbose treatment. Our work highlights the potential for stratification of T2D patients based on their gut microbiota prior to treatment.
Language英语
WOS IDWOS:000416293600001
PublisherNATURE PUBLISHING GROUP
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/169259
Collection中国科学院大连化学物理研究所
Corresponding AuthorKristiansen, Karsten; Ning, Guang; Wang, Weiqing
Affiliation1.Shanghai Jiao Tong Univ, Shanghai Natl Res Ctr Endocrine & Metab Dis, Ruijin Hosp,State Key Lab Med Genom, Shanghai Inst Endocrine & Metab Dis,Sch Med, Shanghai 200025, Peoples R China
2.China Natl GeneBank Shenzhen, BGI Shenzhen, Shenzhen 518083, Peoples R China
3.Univ Chinese Acad Sci, BGI Educ Ctr, Shenzhen 518083, Peoples R China
4.BGI Shenzhen, Shenzhen Key Lab Human Commensal Microorganisms &, Shenzhen 518083, Peoples R China
5.Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, DK-2100 Copenhagen, Denmark
6.BGI Shenzhen, Shenzhen Engn Lab Detect & Intervent Human Intest, Shenzhen 518083, Peoples R China
7.Shanghai Jiao Tong Univ, Med Sch, Renji Hosp, Shanghai 200127, Peoples R China
8.Shanghai Jiao Tong Univ, Med Sch, Xinhua Hosp, Shanghai 200092, Peoples R China
9.Fudan Univ, Med Sch, MinHang Cent Hosp, Shanghai 201100, Peoples R China
10.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
11.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Shanghai 200080, Peoples R China
12.James D Watson Inst Genome Sci, Hangzhou 310008, Zhejiang, Peoples R China
13.Natl Inst Nutr & Seafood Res NIFES, N-5817 Bergen, Norway
Recommended Citation
GB/T 7714
Gu, Yanyun,Wang, Xiaokai,Li, Junhua,et al. Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment[J]. NATURE COMMUNICATIONS,2017,8.
APA Gu, Yanyun.,Wang, Xiaokai.,Li, Junhua.,Zhang, Yifei.,Zhong, Huanzi.,...&Wang, Weiqing.(2017).Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment.NATURE COMMUNICATIONS,8.
MLA Gu, Yanyun,et al."Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment".NATURE COMMUNICATIONS 8(2017).
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