DICP OpenIR
Metabolomics biomarker analysis of threatened abortion in polycystic ovary syndrome: a clinical discovery study
Feng, Xiaoling1; Chen, Lu1; Li, Na1; Zhao, Yan1; Han, Qimao2; Wang, Xiaolin3,4; Wang, Wei1; Ma, Liping1; Zhao, Xinjie3,4
Source PublicationRSC ADVANCES
2017
ISSN2046-2069
DOI10.1039/c6ra27357b
Volume7Issue:83Pages:52923-52929
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordCHROMATOGRAPHY-MASS SPECTROMETRY ; GESTATIONAL DIABETES-MELLITUS ; L-CARNITINE ; DIET ; METABOLISM ; PREDICTION ; PLASMA ; ROLES ; RISK ; LDL
AbstractMetabolomics is the comprehensive assessment of endogenous metabolites of a biological system in a holistic context. Threatened abortion in polycystic ovary syndrome (PCOS) is a heterogeneous disorder with a miscarriage rate of up to 30-50% in women. However, metabolic changes regulated by threatened abortion in women with polycystic ovary syndrome are not clearly understood. Current pregnancy screening tools to identify women with PCOS that are at risk of threatened abortion lack both specificity and sensitivity. In this study, using an advanced metabolomics platform based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS), we found that pregnancy significantly altered the profile of metabolites in the plasma of women with PCOS. Mothers with PCOS and healthy controls could be clustered into two distinct groups based on multivariate statistical analysis. The current metabolomics approach based on UPLC-QTOF-MS indicated 7 ions (6 in the positive mode and 1 in the negative mode) as differentiating metabolites which, to some extent, contribute to the progress of threatened abortion. All these different metabolites led to abnormalities of the fatty acids, lipid metabolism and beta-oxidation of fatty acids in mothers with PCOS. This study was designed to explore the holistic metabolomic profile of threatened abortion as a result of PCOS. To our knowledge, this work is the first report using a metabolomic approach to propose metabolic changes in plasma in the threatened abortion of women with PCOS. Thus, our method is an efficient procedure for the pathogenesis of threatened abortion with mothers with PCOS.
Language英语
WOS IDWOS:000415349700059
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/169275
Collection中国科学院大连化学物理研究所
Corresponding AuthorFeng, Xiaoling; Zhao, Xinjie
Affiliation1.Heilongjiang Univ Chinese Med, Dept Gynecol, Affiliated Hosp 1, Heping Rd 26, Harbin 150040, Heilongjiang, Peoples R China
2.Heilongjiang Univ Chinese Med, Dept Rheumatol, Affiliated Hosp 1, Heping Rd 26, Harbin 150040, Heilongjiang, Peoples R China
3.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Feng, Xiaoling,Chen, Lu,Li, Na,et al. Metabolomics biomarker analysis of threatened abortion in polycystic ovary syndrome: a clinical discovery study[J]. RSC ADVANCES,2017,7(83):52923-52929.
APA Feng, Xiaoling.,Chen, Lu.,Li, Na.,Zhao, Yan.,Han, Qimao.,...&Zhao, Xinjie.(2017).Metabolomics biomarker analysis of threatened abortion in polycystic ovary syndrome: a clinical discovery study.RSC ADVANCES,7(83),52923-52929.
MLA Feng, Xiaoling,et al."Metabolomics biomarker analysis of threatened abortion in polycystic ovary syndrome: a clinical discovery study".RSC ADVANCES 7.83(2017):52923-52929.
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